TY  - JOUR
TI  - Alpha-lipoic acid alleviates lipopolysaccharide-induced liver damage in rats via antioxidant effect
AB  - Objective: The effect of lipoic acid (LA), which is considered to be a potential antioxidant, on oxidative stressparameters in liver tissue damage has not been sufficiently investigated. Therefore, we aimed to investigate therelationship of LA with oxidant and antioxidant parameters in lipopolysaccharide (LPS) induced liver damage in rats.Methods: First group (n=10) was injected a single dose of 20 mg/kg saline (control), second group (n=10) wasinjected a single dose of 20 mg/kg LPS (LPS) and third group (n=10) was injected a single dose of 20 mg/kg LPS at theend of third day of 10 mg/kg/day LA injection (LA+LPS). The glutathione peroxidase (GPX), catalase (CAT) andsuperoxide dismutase (SOD) activities and the levels of malondialdehyde (MDA) were determined byspectrophotometric method. 3-Nitrotyrosine (3-NT) level was measured by high performance liquid chromatography. Results: It was found that 3-NT and MDA levels were significantly lower in LA+LPS group than those of LPS group.Moreover, it was found that antioxidant enzyme activity values of LA+LPS approached to the values of control group.Conclusion: These findings indicate that the oxidant/antioxidant status is balanced in the LA group. Therefore, it maybe suggested that LA supplementation to be beneficial for preventing oxidative stress in LPS-induced liver damage inrats.
AU  - CETİNYUREK--YAVUZ, Aysun
AU  - Çimen, Leyla
AU  - Çimen, Behzat
AU  - ÇETİN, İHSAN
DO  - 10.5798/dicletip.534849
PY  - 2019
JO  - Dicle Tıp Dergisi
VL  - 46
IS  - 1
SN  - 1300-2945
SP  - 125
EP  - 132
DB  - TRDizin
UR  - http://search/yayin/detay/311308
ER  -