The factors and their interrelations that affect the existence and development of central business districts (CBD) as important items in the city are generally examined in the approach that is brought into being by this study. As it is known, cost of the product and competitive environment have a pretty effective role in terms of city population, economy, social and city economic infra-structure that have important effects on the development of central business districts and their inner commercial activities. Consequently, this causes city economy and physical appearance to wear out and become outdated with social change. Within the process of rapid urbanization, the effect of the physical growth of urban spaces in CBD is researched in this study. The restructuring of CBD according to their physical and economical contents is analyzed in the case of Eskişehir. The results of this analysis are considered to be guide and useful for the future city planning in terms of strategic policy and proper measures. By analyzing spatial progress of CBD in certain period that have a multi-varied structure with service sectors like management, supervision, commerce, social and cultural activities as a reflection of city of Eskişehir socio-economic base, to point out directions of the progress, factors and their effects that cause the progress and to make the decisions of progress in the city-land of Eskişehir for next 30 year term are aimed.