Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study

Sandeep KASHYAP, (Department of Orthopedics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India)
Shweta MAHAJAN, (Department of Anesthesia and Critical Care, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India)
Mukand LAL (Department of Orthopedics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India)
Acta Orthopaedica et Traumatologica Turcica
2 0
Yıl: 2019 Cilt: 53 Sayı: 3 Sayfa Aralığı: 175 - 179 Metin Dili: İngilizce DOI: 10.1016/j.aott.2019.03.006 İndeks Tarihi: 31-10-2019

Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study

Öz:
Objective: The aim of this study was to assess the effect of topical tranexamic acid on blood loss and transfusion rates in acetabular fracture surgery. Methods: The medical records of 61 patients who underwent open reduction and internal fixation for acetabular fracture between 2012 and 2015 were retrospectively reviewed. The patients were divided into two groups: Group I consisted of 31 patients (19 men and 12 women, mean age: 52 ± 19 years) who received intraoperatively a topical tranexamic acid solution of 3 g and Group 2 consisted of 30 control patients (17 men and 13 women, mean age: 48 ± 24 years) who received only 0.9% saline solution. The groups were compared based on their intraoperative blood loss, Postoperative drain output at 24 and 48 h, and postoperative hemoglobin levels, and transfusion rates. Results: The mean intraoperative blood loss was 410 ± 100 ml in Group 1, compared to 570 ml ± 160 ml of the control group (p < 0.05). The postoperative drain output after 24 h was 210 ± 70 ml in Group 1 compared to 330 ± 90 ml of the control group (p < 0.05). The drain output at 48 h was (50 ± 20 ml) in group 1 compared to 90 ± 40 ml of the control group (p < 0.05). The transfusion rate was significantly low group 1 (42%) than the control group (97%). Hemoglobin drop was again significantly less in tranexamic acid group (2.1 ± 1.1) than the control group (3.2 ± 1.3). The nadir postoperative hemoglobin was higher in the Group 1 (10.4 ± 1.5) than the control group (9.2 ± 1.3). Conclusion: Topical administration of tranexamic acid reduces intraoperative and postoperative blood loss in acetabular fracture surgery, decreasing transfusion rates.
Anahtar Kelime:

Konular: Ortopedi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
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APA KASHYAP S, MAHAJAN S, LAL M (2019). Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. , 175 - 179. 10.1016/j.aott.2019.03.006
Chicago KASHYAP Sandeep,MAHAJAN Shweta,LAL Mukand Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. (2019): 175 - 179. 10.1016/j.aott.2019.03.006
MLA KASHYAP Sandeep,MAHAJAN Shweta,LAL Mukand Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. , 2019, ss.175 - 179. 10.1016/j.aott.2019.03.006
AMA KASHYAP S,MAHAJAN S,LAL M Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. . 2019; 175 - 179. 10.1016/j.aott.2019.03.006
Vancouver KASHYAP S,MAHAJAN S,LAL M Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. . 2019; 175 - 179. 10.1016/j.aott.2019.03.006
IEEE KASHYAP S,MAHAJAN S,LAL M "Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study." , ss.175 - 179, 2019. 10.1016/j.aott.2019.03.006
ISNAD KASHYAP, Sandeep vd. "Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study". (2019), 175-179. https://doi.org/10.1016/j.aott.2019.03.006
APA KASHYAP S, MAHAJAN S, LAL M (2019). Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. Acta Orthopaedica et Traumatologica Turcica, 53(3), 175 - 179. 10.1016/j.aott.2019.03.006
Chicago KASHYAP Sandeep,MAHAJAN Shweta,LAL Mukand Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. Acta Orthopaedica et Traumatologica Turcica 53, no.3 (2019): 175 - 179. 10.1016/j.aott.2019.03.006
MLA KASHYAP Sandeep,MAHAJAN Shweta,LAL Mukand Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. Acta Orthopaedica et Traumatologica Turcica, vol.53, no.3, 2019, ss.175 - 179. 10.1016/j.aott.2019.03.006
AMA KASHYAP S,MAHAJAN S,LAL M Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. Acta Orthopaedica et Traumatologica Turcica. 2019; 53(3): 175 - 179. 10.1016/j.aott.2019.03.006
Vancouver KASHYAP S,MAHAJAN S,LAL M Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study. Acta Orthopaedica et Traumatologica Turcica. 2019; 53(3): 175 - 179. 10.1016/j.aott.2019.03.006
IEEE KASHYAP S,MAHAJAN S,LAL M "Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study." Acta Orthopaedica et Traumatologica Turcica, 53, ss.175 - 179, 2019. 10.1016/j.aott.2019.03.006
ISNAD KASHYAP, Sandeep vd. "Effects of topical tranexamic acid during open reduction and internal fixation of acetabular fractures: A retrospective study". Acta Orthopaedica et Traumatologica Turcica 53/3 (2019), 175-179. https://doi.org/10.1016/j.aott.2019.03.006
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23-04-2024 9:10

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