Aim: In this in vitro study, the effect of finish line and coping design on the fracture resistance of veneer porcelains on the zirconia frameworks prepared through various methods was analyzed. Material and Methods: To standardization, the dies representing the upper first premolar tooth were prepared in the CNC turning machine as: the first die; with a 6 mm crown length and at 60 taper angle, having an anatomic occlusal surface with a 1 mm shoulder line, the second die; with a 6 mm crown length and at 60 taper angle, having an anatomic occlusal surface with a 1 mm chamfer line, the third die; with a 6 mm crown length and at 60 taper angle, having a flat occlusal surface with a 1 mm shoulder line, and the fourth die; with a 6 mm crown length and at 60 taper angle, having a 1 mm chamfer line with a flat occlusal surface. 60 pieces of epoxy resin dies were obtained from the measurements taken from the dies. Zirconia frameworks had been prepared through different methods, then crowns were completed by applying the body porcelain. After cementation the crowns on the epoxy resin dies, the fracture resistance of veneer porcelains was measured by the Universal Test device. Results: The data were analyzed by three-way variance analysis (ANOVA). It was statistically determined that the interaction between the finish line, coping design and materials; and the materials and coping design, and the finish line and the materials. However; no significant interaction was observed between the finish line and coping design; and the materials, coping design and the finish line. Conclusion: The highest fracture resistance values of veneer porcelain was seen in chamfer line White Peaks crowns prepared anatomically, whereas the framework of the lowest fracture resistance values was seen in the chamfer line Lava crowns.