Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital
Yıl: 2019 Cilt: 25 Sayı: 2 Sayfa Aralığı: 74 - 80 Metin Dili: İngilizce DOI: 10.201613/GORM.2019.903 İndeks Tarihi: 01-11-2019
Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital
Öz: OBJECTIVE: The present study was designed to determine the seroprevalence of Toxoplasma gondii,Rubella, and Cytomegalovirus, to investigate the frequency of low and high avidity results among preg-nant women and to contribute to the data of our country with the results obtained.STUDY DESIGN: In the present study, the hospital records of the women who applied to the antenataloutpatient of the Rize Recep Tayyip Erdogan University Medical Faculty during the first trimester be-tween January 2016 and October 2018 were retrospectively reviewed. Toxoplasma gondii, RRubellaand Cytomegalovirus IgM, IgG and IgG avidity results were evaluated.RESULT: IgM positivity was found to be 0.83% (29/3490) for Toxoplasma gondii, 0.92% (32/3459) forRubella and 1.90% (65/3404) for Cytomegalovirus; IgG positivity was found to be 33.64% (1174/3490)for Toxoplasma gondii, 90.70% for Rubella (3140/3459), and 99.17% (3376/3404) for Cytomegalovirus.Avidity of Toxoplasma gondii was found to be low (3.70%) in 1 patient, borderline (11.11%) in 3 patients,and high avidity in 23 patients (85.18%). Avidity of Cytomegalovirus was found to be low (1.75%) in 1patient, borderline (3.50%) in 2 patients and high avidity (94.73%) in 54 patients. Avidity of Rubella wasfound to be low (4%) in 1 patient, and high avidity (96%) was found in 24 patients.CONCLUSIONS: In our study, although the prevalence of acute infection with Rubella, Cytomegalovirusand Toxoplasma gondii was shown to be low in pregnancy in Rize province, serological screening testsfor monitoring and informing high-risk groups that are particularly seronegative appear to be important.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Yadav RK, Maity S, Saha S. A review on TORCH: groups of congenital infection during pregnancy. J Sci Innovat Res. 2014;3(2):258-64.
- Silasi M, Cardenas I, Kwon JY, Racicot K, Aldo P, Mor G. Viral infections during pregnancy. Am J Reprod Immunol. 2015;73(3):199-213.
- Ornoy A, Diav-Citrin O. Fetal effects of primary and sec- ondary cytomegalovirus infection in pregnancy. Reprod Toxicol. 2006;21(4):399-409.
- Turbadkar D, Mathur M, Rele M. Seroprevalence of torch infection in bad obstetric history. Indian J Med Microbiol. 2003;21(2):108-10.
- Devakumar D, Bamford A, Ferreira MU, Broad J, Rosch RE, Groce N, et al. Infectious causes of microcephaly: epidemiology, pathogenesis, diagnosis, and management. Lancet Infect Dis. 2018;18(1):1-13.
- Dhakal R, Gajurel K, Pomares C, Talucod J, Press CJ, Montoya JG. Significance of a positive toxoplasma im- munoglobulin M test result in the United States. J Clin Microbiol. 2015;53(11):3601-5.
- Mendelson E, Aboudy Y, Smetana Z, Tepperberg M, Grossman Z. Laboratory assessment and diagnosis of congenital viral infections: Rubella, cytomegalovirus (CMV), varicella-zoster virus (VZV), herpes simplex virus (HSV), parvovirus B19 and human immunodeficiency virus (HIV). Reprod Toxicol. 2006;21(4):350-82.
- Prince HE, Lape-Nixon M. Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clin Vaccine Immunol. 2014; 21(10):1377-84.
- Duran B, Toktamış A, Erden Ö, Demirel Y, Mamik BA, Çetin M. A Contraversial Issue in Antenatal Care: TORCH Screening. Cumhuriyet Medical Journal. 2002;24:185- 190.
- Sroka J, Wojcik-Fatla A, Szymanska J, Dutkiewicz J, Zajac V, Zwolinski J. The occurrence of Toxoplasma gondii infection in people and animals from rural environment of Lublin region - estimate of potential role of water as a source of infection. Ann Agric Environ Med. 2010;17(1):125-32.
- Edelhofer R, Prossinger H. Infection with Toxoplasma gondii during pregnancy: seroepidemiological studies in Austria. Zoonoses Public Health. 2010;57(1):18-26.
- Gilbert RE, Gras L, Wallon M, Peyron F, Ades AE, Dunn DT. Effect of prenatal treatment on mother to child trans- mission of Toxoplasma gondii: retrospective cohort study of 554 mother-child pairs in Lyon, France. Int J Epidemiol. 2001;30(6):1303-8.
- Montoya JG, Liesenfeld O. Toxoplasmosis. Lancet. 2004;363(9425):1965-76.
- Uyar Y, Alcı A, Akçalı A, Cabar C. Prevalence of rubella and cytomegalovirus antibodies among pregnant women in northern Turkey. New Microbiol. 2008;31(4):451-5.
- Tamer GS, Dundar D, Caliskan E. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in western region of Turkey. Clin Invest Med. 2009; 32(1):43-7.
- Karabulut A, Polat Y, Türk M, Isik Balci Y. Evaluation of rubella, Toxoplasma gondii and cytomegalovirus sero- prevalemces among pregnant women in Denizli province. Turk J Med Sci. 2011;41(1):159-64.
- Doğan K, Güraslan H, Özel G, Aydan Z, Yaşar L. Seroprevalence rates of Toxoplasma gondii, rubella, cy- tomegalovirus, syphilis, and hepatitis B, seroprevalences rate in the pregnant population in İstanbul. Turkiye Parazitol Derg. 2014;38(4):228-33.
- Çeltek NY, Tetikçok R, Günal Ö, Demirtürk F, Duygu F, Barut HŞ, et al. Seroprevalence for rubella, CMV and Toxoplasmosis among pregnant women in central black sea region of Turkey. Med J Tokat Gaziosmanpasa University. 2014;6(1):54-62.
- Inci A, Yener C, Güven D. The investigation of toxo- plasma, rubella and cytomegalovirus seroprevalancies in pregnant women in a state hospital. Pamukkale Med J. 2014;7(2):143-46.
- Karacan M, Batukan M, Cebi Z, Berberoglugil M, Levent S, Kır M, et al. Screening cytomegalovirus, rubella and toxoplasma infections in pregnant women with unknown pre-pregnancy serological status. Arch Gynecol Obstet. 2014;290(6):1115-20.
- Duran İ, Nazik S, Nazik H, Duran Ş. Evaluation of toxo- plasma and rubella seropositivity in pregnancy. Balıkesir Med J. 2017;1(1):22-5.
- Parlak M, Çim N, Nalça Erdin B, Güven A, Bayram Y, Yıldızhan R. Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus among pregnant women in Van. Turk J Obstet Gynecol. 2015;12(2):79-82.
- Bakacak M, Bostancı MS, Köstü B, Ercan Ö, Serın S, Avcı F, et al. Seroprevalance of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women. Dicle Med J. 2014;41(2):326-31.
- Aynioglu A, Aynioglu O, Altunok ES. Seroprevalence of toxoplasma gondii, rubella and cytomegalovirus among pregnant females in north-western Turkey. Acta Clin Belg. 2015;70(5):321-4.
- Şimşek M, Keşli R, Demir C, Çetinkaya Ö, Arıöz DT. Investigation seroprevalence of toxoplasma, rubella, cy- tomegalovirus and herpes simplex virus type 2 in pregnant women followed in the application and research hospital, Afyon Kocatepe University. Ortadogu Med J. 2016; 8(1):1-6.
- Numan O, Vural F, Aka N, Alpay M, Coskun AD. TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital af- filiated to Association of Istanbul Northern Anatolia Public Hospitals. North Clin Istanb. 2015;2(3):203-9.
- Kasap B, Öner G, Küçük M, Öztürk Turhan N, Akın MN, Arıkan S, et al. Evaluation of Toxoplasmosis, Rubella, Cytomegalovirus and Hepatitis prevalence of pregnant women in Muğla. J Tepecik Edu Res Hos. 2017;27(1):31- 6.
- Sirin MC, Agus N, Yilmaz N, Bayram A, Derici YK, Samlioglu P, et al. Seroprevalence of Toxoplasma gondii, rubella virus and cytomegalovirus among pregnant women and the importance of avidity assays. Saudi Med J. 2017;38(7):727-32.
- Madendağ Y, Eraslan Şahin M, Çöl Madendağ İ, Şahin E, Açmaz G, Müdderris İİ. Investigation of toxoplasma, cy- tomegalovirus and rubella seroprevalence in pregnant women admitted to our hospital. Perinat J. 2018;26(1):7- 10.
- Wang S, Wang T, Zhang W, Liu X, Wang X, Wang H, et al. Cohort study on maternal cytomegalovirus seropreva- lence and prevalence and clinical manifestations of con- genital infection in China. Medicine (Baltimore). 2017;96(5): e6007.
- Leruez-Ville M, Sellier Y, Salomon LJ, Stirnemann JJ, Jacquemard F, Ville Y. Prediction of fetal infection in cases with cytomegalovirus immunoglobulin M in the first trimester of pregnancy: a retrospective cohort. Clin Infect Dis. 2013;56(10):1428-35.
- Sert Y, Ozgu-Erdinc AS, Saygan S, Engin Ustun Y. Antenatal Cytomegalovirus Infection Screening Results of 32,188 Patients in a Tertiary Referral Center: A Retrospective Cohort Study. Fetal Pediatr Pathol. 2019:1- 9. doi: 10.1080/15513815.2018.1552732 [Epub ahead of print]
- Dollard SC, Staras SA, Amin MM, Schmid DS, Cannon MJ. National prevalence estimates for cytomegalovirus IgM and IgG avidity and association between high IgM antibody titer and low IgG avidity. Clin Vaccine Immunol. 2011;18(11):1895-9.
- WHO. Global Measles and Rubella Strategic Plan 2012- 2020 [Internet]. Geneva (Switzerland): WHO; 2012 [con- sulted on 8 February 2017]. Available from: http://apps. who.int/iris/bitstream/10665/44855/1/9789241503396_ eng.pdf
- Sert UY, Ozgu-Erdinc AS, Saygan S, Engin-Ustun Y. The Prevalence of anti-rubella antibodies in pregnant women of Turkey, results of 94508 patients in a tertiary referral center. Z Geburtshilfe Neonatol. 2018. doi: 10.1055/a- 0755-2695. [Epub ahead of print]
- Osmanağaoğlu M, Aran T, Güven S, Kart C, Bozkaya H. Rubella vaccination during pregnancy Trabzon Turkey 2009. Gynecol Obstet Reprod Med. 2010;16(3):149-51.
| APA | GÜRLEK B, ÇOLAK S (2019). Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. , 74 - 80. 10.201613/GORM.2019.903 |
| Chicago | GÜRLEK BERIL,ÇOLAK SABRİ Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. (2019): 74 - 80. 10.201613/GORM.2019.903 |
| MLA | GÜRLEK BERIL,ÇOLAK SABRİ Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. , 2019, ss.74 - 80. 10.201613/GORM.2019.903 |
| AMA | GÜRLEK B,ÇOLAK S Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. . 2019; 74 - 80. 10.201613/GORM.2019.903 |
| Vancouver | GÜRLEK B,ÇOLAK S Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. . 2019; 74 - 80. 10.201613/GORM.2019.903 |
| IEEE | GÜRLEK B,ÇOLAK S "Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital." , ss.74 - 80, 2019. 10.201613/GORM.2019.903 |
| ISNAD | GÜRLEK, BERIL - ÇOLAK, SABRİ. "Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital". (2019), 74-80. https://doi.org/10.201613/GORM.2019.903 |
| APA | GÜRLEK B, ÇOLAK S (2019). Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. GORM:Gynecology Obstetrics & Reproductive Medicine, 25(2), 74 - 80. 10.201613/GORM.2019.903 |
| Chicago | GÜRLEK BERIL,ÇOLAK SABRİ Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. GORM:Gynecology Obstetrics & Reproductive Medicine 25, no.2 (2019): 74 - 80. 10.201613/GORM.2019.903 |
| MLA | GÜRLEK BERIL,ÇOLAK SABRİ Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.25, no.2, 2019, ss.74 - 80. 10.201613/GORM.2019.903 |
| AMA | GÜRLEK B,ÇOLAK S Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. GORM:Gynecology Obstetrics & Reproductive Medicine. 2019; 25(2): 74 - 80. 10.201613/GORM.2019.903 |
| Vancouver | GÜRLEK B,ÇOLAK S Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital. GORM:Gynecology Obstetrics & Reproductive Medicine. 2019; 25(2): 74 - 80. 10.201613/GORM.2019.903 |
| IEEE | GÜRLEK B,ÇOLAK S "Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital." GORM:Gynecology Obstetrics & Reproductive Medicine, 25, ss.74 - 80, 2019. 10.201613/GORM.2019.903 |
| ISNAD | GÜRLEK, BERIL - ÇOLAK, SABRİ. "Antenatal Toxoplasma Gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital". GORM:Gynecology Obstetrics & Reproductive Medicine 25/2 (2019), 74-80. https://doi.org/10.201613/GORM.2019.903 |
