Yıl: 2019 Cilt: 15 Sayı: 1 Sayfa Aralığı: 8 - 13 Metin Dili: Türkçe DOI: 10.5505/yeditepe.2019.63634 İndeks Tarihi: 06-11-2019

Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi

Öz:
Amaç: Bu çalışmanın amacı, agresif periodontitisli hastalarda(AgP) dişeti oluğu sıvısında (DOS) İnterlökin-1beta (IL-1β) veoksidan-antioksidan seviyelerine cerrahi olmayan periodontal tedavinin etkilerini belirlemektir.Gereç ve Yöntem: Çalışma için sigara içmeyen periodontalolarak sağlıklı 12 birey ve generalize agresif periodontitisli(G-AgP) 14 bireyi içeren 26 kişi dahil edildi. Sondlanabilir cepderinliği (SCD), klinik ataşman seviyesi (KAS), gingival indeks(Gİ), plak indeksi (Pİ), sondlanamada kanama (SK) ölçüldü. Total oksidan seviyelerini(TOS) ve total antioksidan seviyelerini(TAS) belirlemek için her bir hastadan DOS örnekleri alındı.DOS ve klinik ölçümler başlangıçta ve periodontal tedaviden6 hafta sonra kaydedildi.Bulgular: Çalışma periodontal tedavi sonrası klinik parametrelerde istatistiksel olarak önemli iyileşme gösterdi. G-AgPhasta grubunda başlangıç ve 6.hafta arasında DOS IL-1βseviyeleri arasında önemli bir farklılık yoktu (p>0,05). G-AgPhastalarında TOS seviyesinin 6. haftada başlangıçtan önemliölçüde azaldığı bulundu (p<0,05).Sonuçlar: Çalışmanın bu sınırları içerisinde; G-AgP hastalarında, enflamasyon esnasında artış gösteren TOS seviyesi cerrahi olmayan periodontal tedavi yapılarak düzenlenebilir.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Diş Hekimliği

The effects of periodontal therapy on oxidant and antioxidant status in patients with aggressive periodontitis

Öz:
Aim: The aim of this study was to determine the effect of non-surgical periodontal therapy on gingival crevicular fluid (GCF), interleukin 1βeta (IL-β) and oxidant-antioxidant levels in patients with aggressive periodontitis. Materials and Method: Twenty-six subjects, including 14 generalized aggressive periodontitis (G-AgP) and 12 periodontally healthy non-smoker individuals were selected for the study. Probing pocket depth (PPD), clinical attachment level (CAL), gingival (GI) and plaque indices (PI), and bleeding on probing (BOP) were measured. To determine total oxidant status (TOS) and total antioxidant status (TAS) and IL-1β, GCF was drawn from each subject. The GCF and clinical measurements were recorded at baseline and 6 weeks after periodontal treatment. Conclusions: The study showed statistically significant improvement of clinical parameters after periodontal treatment. There was no significant difference in GCF IL-1β levels between the baseline and 6 weeks in the G-AgP patients group (p > 0.05). The TOS levels at 6 weeks of the G-AgP patients group were significantly lower than those at baseline (p < 0.05). Within the limitations of this study it can be concluded that GCF TOS level in G-AgP patients increased during the inflammation and can be restored by the non-surgical periodontal therapy.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Diş Hekimliği
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
0
0
0
  • Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1:1-6.
  • Gonzales JR, Michel J, Diete A, Herrmann JM, Bödeker RH, Meyle J. Analysis of genetic polymorphisms at the interleukin-10 loci in aggressive periodontitis and chronic periodontitis. J ClinPeriodontol 2002;29:816-822.
  • Masada MP, Persson R, Kenney JS, Lee SW, Page RC, Allison AC. Measurement of interleukin-1 alpha and -1 beta in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. J Periodontal Res 1990;25:156-163.
  • Preiss DS, Meyle J. Interleukin-1 beta concentration of gingival crevicular fluid. J Periodontol 1994;65:423-428.
  • Tüter G, Kurtiş B, Serdar M. Interleukin-1beta and thiobarbituric acid reactive substance (TBARS) levels after phase I periodontal therapy in patients with chronic periodontitis. J Periodontol 2001;72:883-888.
  • Engebretson SP, Lamster IB, Herrera-Abreu M, Celenti RS, Timms JM, Chaudhary AG, di Giovine FS, Kornman KS. The influence of interleukin gene polymorphism on expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid. J Periodontol 1999;70:567-573.
  • Gamonal J, Acevedo A, Bascones A, Jorge O, Silva A. Levels of interleukin-1 beta, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. J Periodontol 2000;71:1535-1545.
  • Zeidán-Chuliá, Neves de Oliveira BH, Gursoy M, Könönen E, Fonseca Moreira JC, Gursoy UK, Uitto VJ. MMP-REDOX/NO interplay in periodontitis and its inhibition with Saturejahortensis L. essential oil.ChemBiodivers. 2013;10:507-523.
  • Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999;10:458-476.
  • Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol 2003;91:7A-11A.
  • Konopka T, Król K, Kopeć W, Gerber H. Total antioxidant status and 8-hydroxy-2'-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients. Arch ImmunolTherExp 2007;55:417-422.
  • Toker H, Akpınar A, Aydın H, Poyraz O. Influence of smoking on interleukin-1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodontal Res 2012;47:572-577.
  • Brock GR, Butterworth CJ, Matthews JB, Chapple IL. Local and systemic total antioxidant capacity in periodontitis and health. J ClinPeriodontol 2004;31:515-521.
  • Wei D, Zhang XL, Wang YZ, Yang CX, Chen G. Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in choronic periodontitis patients before and after periodontal therapy. Aus Dent J 2010;55:70-78.
  • Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-616.
  • Lindhe J, Karring T. Lang NP. Clinical Periodontology and Implant Dentistry. Oxford: Blackwell Munksgaard; 2008:504-525.
  • Erel O. A new automated colorimetric method for measuring total oxidant status. ClinBiochem 2005;38:1103- 1111.
  • Erel O. A novel automated method to measure total antioxidant response against potent free radical reacti ons. Clin Biochem 2004;37:112-119.
  • Baltacıoğlu E, Kehribar MA, Yuva P, Alver A, Atagün ÖS, Karabulut E, Akalın FA. Total Oxidant Status and Bone Resorption Biomarkers in Serum and Gingival Crevicular Fluid of Patients With Periodontitis. J Periodontol 2014;85:317-326.
  • Takahashi K, Ohyama H, Kitanaka M, Sawa T, Mineshiba J, Nishimura F, Arai H, Takashiba S, Murayama Y. Heterogeneity of host immunological risk factors in patients with aggressive periodontitis. J Periodontol 2001;72:425- 437.
  • Toker H, Poyraz O, Eren K. Effects of periodontal treatment on IL-1β, IL-ra and IL-10 levels in gingival crevicular fluid in patients with agressive periodontitis. J ClinPeriodontol 2008;35:507-513.
  • Oliveira APL, Faveri M, Gursky LC, Mestnik MJ, Feres M, Haffajee AD, Socransky SS, Teles RP. Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. J ClinPeriodontol 2012;39:295- 302.
  • Toker H, Marakoglu I, Poyraz O. Effect of meloxicam on gingival crevicular fluid IL-1beta and IL1 receptor antagonist levels in subjects with chronic periodontitis, and its effects on clinical parameters. Clin Oral Investig 2006;10:305-310.
  • Akalin FA, Baltacioğlu E, Alver A, Karabulut E. Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J ClinPeriodontol 2007;34:558-65.
  • D’Aiuto F, Nibali L, Parkar M, Patel K, Suvan J, Donos N. Oxidative stress, systemic inflammation and severe periodontitis. J Dent Res 2010;89:1241-1246.
  • Armitage G, Cullinan MP, Seymour GJ. Comparison of the clinical features of chronic and aggressive periodontitis. Periodontol 2000 2010;53:12-27.
  • Kantarci A, Van Dyke TE. Resolution of inflammation in periodontitis. J Periodontol 2005;76:2168-2174.
  • Asman B, Bergstrom K, Wijkander P, Lockowandt B. Peripheral PMN cell activity in relation to treatment of juvenile periodontitis Scand. J Dent Res 1988;96:418-420.
  • Suzuki JB, Risom L, Falkler WA Jr, Collison C, Bowers G. Effect of periodontal therapy on spontaneous lymphocyte response and neutrophil chemotaxis in localized and generalized juvenile periodontitis patients. J ClinPeriodontol 1985;12:124-134.
  • Sculley DV, Langley-Evans SC. Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation. ClinSci (Lond). 2003;105
APA AKPINAR A, TOKER H, BOSTANCI V, POYRAZ Ö, Aydin H (2019). Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. , 8 - 13. 10.5505/yeditepe.2019.63634
Chicago AKPINAR Aysun,TOKER HÜLYA,BOSTANCI Vildan,POYRAZ Ömer,Aydin Huseyin Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. (2019): 8 - 13. 10.5505/yeditepe.2019.63634
MLA AKPINAR Aysun,TOKER HÜLYA,BOSTANCI Vildan,POYRAZ Ömer,Aydin Huseyin Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. , 2019, ss.8 - 13. 10.5505/yeditepe.2019.63634
AMA AKPINAR A,TOKER H,BOSTANCI V,POYRAZ Ö,Aydin H Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. . 2019; 8 - 13. 10.5505/yeditepe.2019.63634
Vancouver AKPINAR A,TOKER H,BOSTANCI V,POYRAZ Ö,Aydin H Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. . 2019; 8 - 13. 10.5505/yeditepe.2019.63634
IEEE AKPINAR A,TOKER H,BOSTANCI V,POYRAZ Ö,Aydin H "Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi." , ss.8 - 13, 2019. 10.5505/yeditepe.2019.63634
ISNAD AKPINAR, Aysun vd. "Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi". (2019), 8-13. https://doi.org/10.5505/yeditepe.2019.63634
APA AKPINAR A, TOKER H, BOSTANCI V, POYRAZ Ö, Aydin H (2019). Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. 7tepe Klinik, 15(1), 8 - 13. 10.5505/yeditepe.2019.63634
Chicago AKPINAR Aysun,TOKER HÜLYA,BOSTANCI Vildan,POYRAZ Ömer,Aydin Huseyin Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. 7tepe Klinik 15, no.1 (2019): 8 - 13. 10.5505/yeditepe.2019.63634
MLA AKPINAR Aysun,TOKER HÜLYA,BOSTANCI Vildan,POYRAZ Ömer,Aydin Huseyin Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. 7tepe Klinik, vol.15, no.1, 2019, ss.8 - 13. 10.5505/yeditepe.2019.63634
AMA AKPINAR A,TOKER H,BOSTANCI V,POYRAZ Ö,Aydin H Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. 7tepe Klinik. 2019; 15(1): 8 - 13. 10.5505/yeditepe.2019.63634
Vancouver AKPINAR A,TOKER H,BOSTANCI V,POYRAZ Ö,Aydin H Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi. 7tepe Klinik. 2019; 15(1): 8 - 13. 10.5505/yeditepe.2019.63634
IEEE AKPINAR A,TOKER H,BOSTANCI V,POYRAZ Ö,Aydin H "Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi." 7tepe Klinik, 15, ss.8 - 13, 2019. 10.5505/yeditepe.2019.63634
ISNAD AKPINAR, Aysun vd. "Agresif periodontitisli hastalarda periodontal tedavinin oksidan ve antioksidan seviyeleri üzerine etkisi". 7tepe Klinik 15/1 (2019), 8-13. https://doi.org/10.5505/yeditepe.2019.63634