TY  - JOUR
TI  - Comparison of optic coherence tomography results in patients diagnosed with OCD: findings in favor of neurodegeneration
AB  - Objective: Optic coherence tomography (OCT) is a contactless and fast neuroimaging method. Previous studieshave observed thinning of the ganglion cell layer (GCL) and inner plexiform layer (IPL) in many neurodegenerativediseases. The aim of this study was to compare the GCL volume, retinal nerve fiber layer (RNFL), and IPL thicknessin obsessive compulsive patients and controls using OCT to demonstrate neurodegeneration in obsessive compul-sive disorder (OCD). Methods: This study involved 50 OCD patients who were being followed by the PsychiatryDepartment of Adiyaman University Medical School and 50 healthy volunteers as control. OCT measurements wereperformed for both groups. The RNFL, IPL thickness, and GCL volumes were measured and recorded automaticallyby a spectral OCT device. Results: The RNFL thickness was lower in patients compared with controls at all mea-sured regions, and this decrease statistically significant in a few regions (left temporo-superior, left mean). The leftand right choroid layer thickness acquired from three regions of choroid layer was higher in patients compared withcontrols. The GCL and IPL volumes were also significantly lower in the patient group. There was a significant nega-tive correlation between the disease duration and OCT results. Discussion: These findings suggest that neurode-generation occurs during the course of OCD. This degeneration may be demonstrated by decreased GCL at earlystages, and as the disease progresses, involvement of other retinal layers, such as the RNFL and IPL, may beobserved. (Anatolian Journal of Psychiatry 2019; 20(2):166-174)
AU  - karadag, ayse sevgi
AU  - KALENDEROĞLU, Aysun
AU  - Örüm, Mehmet Hamdi
AU  - Özen, Murat Eren
DO  - 10.5455/apd.301482
PY  - 2019
JO  - Anadolu Psikiyatri Dergisi
VL  - 20
IS  - 2
SN  - 1302-6631
SP  - 166
EP  - 174
DB  - TRDizin
UR  - http://search/yayin/detay/313077
ER  -