TY  - JOUR
TI  - Effects of Hypothyroidism on Central and Peripheral Atherosclerosis in the Old Aged
AB  - Objectives: Aging is associated with an increased incidence of thyroid function abnormalities. Thyroid hormones have been shown to affect vascularhemodynamics and arterial stiffness. Arterial stiffness appears to be an essential risk factor for cardiovascular disease. The long-term effect ofhypothyroidism on the development of the peripheral arterial disease is not well understood. Pulse wave velocity (PWV) is a simple, non-invasivemarker of atherosclerosis that measures arterial stiffness. Ankle brachial index (ABI) is a non-invasive technique commonly used to detect peripheralvascular diseases. A limited number of studies evaluated hypothyroidism as a risk factor for both peripheral arterial disease and arterial stiffness inthe old aged. We aimed to investigate this relationship in older patients and then compared with their younger counterparts.Materials and Methods: A total of 22 patients ≥65 years of age and 23 younger patients with hypothyroidism and 23 gender-matched, and bodymass index-matched old aged individuals with euthyroidism as controls were enrolled in this study. Old aged patients with hypothyroidism weredefined as group I, old aged individuals with euthyroidism were defined as group II, and younger patients with hypothyroidism were defined asgroup III. PWV was measured between the carotid and femoral arteries. ABI was measured by a handheld Doppler.Results: PWV was similar (0.36) in older groups (groups I and II) and was lower (p < 0.001) in group III. ABI measurements (left and right) weresimilar in all groups (p > 0.05). More than half of the patients with hypothyroidism had subclinical hypothyroidism, and this condition was similarin all groups (p = 0.26). We also compared patients with hypothyroidism (group I plus III) with older controls with euthyroidism (group II). Medianage was higher in group II than that in group I plus III (p < 0.001). PWV was higher in group II than that in group I plus III (p < 0.001). Hypertensionwas more common in group II than in group I plus III (p < 0.001).Conclusion: We did not find a relationship between hypothyroidism and atherosclerosis in old aged. PWV and hypertension were higher in olderpatients with hypothyroidism than in younger. Aging and hypertension increased PWV. Studies with larger series are needed to increase thereliability of these results.
AU  - Atmış, Volkan
AU  - EVRANOS ÖĞMEN, Berna
AU  - ATLI, Teslime
AU  - ERDOĞAN, MURAT FAİK
DO  - 10.4274/atfm.galenos.2019.70883
PY  - 2019
JO  - Ankara Üniversitesi Tıp Fakültesi Mecmuası
VL  - 72
IS  - 2
SN  - 0365-8104
SP  - 167
EP  - 173
DB  - TRDizin
UR  - http://search/yayin/detay/314821
ER  -