An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury

Kaya, Yasin Emre

doi:10.5455/annalsmedres.2018.12.281

An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury

Yasin Emre KAYA (Bolu Abant İzzet Baysal Üniversitesi)

Annals of Medical Research

7 1

Yıl: 2019 Cilt: 26 Sayı: 3 Sayfa Aralığı: 521 - 528 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2018.12.281 İndeks Tarihi: 24-12-2019

An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury

Öz:

Aim: In the present study, we aimed to systematically evaluate the effects of gabapentin and pregabalin, which are believed to be safe and well-tolerated and have analgesic, anticonvulsant, and anxiolytic effects, in the treatment of neuropathic pain after spinal cord injury despite their high side effect profiles.Material and Methods: A literature search of numerous electronic databases was performed. A combination of key words was used to retrieve studies published until November 1, 2018 correlated with the point of interest. The key words used were as follows: “spinal cord injury,” “neuropathic pain,” “gabapentin,” and “pregabalin.” Studies that met the inclusion criteria and were Level of I clinical trials were included in the study. The included studies were statistically evaluated.Results: In total, 125,515 publications were retrieved using the aforementioned key words. 19 studies on the use of gabapentin and pregabalin for the treatment of neuropathic pain associated with spinal cord injury were retrieved through.Conclusion: Studies suggested that available treatment modalities did not provide satisfactory outcomes for patients with neuropathic pain related to spinal cord injury. However, gabapentin and pregabalin were preferred as the first-line drugs in the treatment of neuropathic pain. The efficacy of gabapentin in the treatment of neuropathic pain after spinal cord injury has only been investigated in a few recent studies; data in these studies are not sufficiently clear and will need further clarification.

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APA	Kaya Y (2019). An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. , 521 - 528. 10.5455/annalsmedres.2018.12.281
Chicago	Kaya Yasin Emre An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. (2019): 521 - 528. 10.5455/annalsmedres.2018.12.281
MLA	Kaya Yasin Emre An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. , 2019, ss.521 - 528. 10.5455/annalsmedres.2018.12.281
AMA	Kaya Y An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. . 2019; 521 - 528. 10.5455/annalsmedres.2018.12.281
Vancouver	Kaya Y An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. . 2019; 521 - 528. 10.5455/annalsmedres.2018.12.281
IEEE	Kaya Y "An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury." , ss.521 - 528, 2019. 10.5455/annalsmedres.2018.12.281
ISNAD	Kaya, Yasin Emre. "An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury". (2019), 521-528. https://doi.org/10.5455/annalsmedres.2018.12.281

APA	Kaya Y (2019). An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. Annals of Medical Research, 26(3), 521 - 528. 10.5455/annalsmedres.2018.12.281
Chicago	Kaya Yasin Emre An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. Annals of Medical Research 26, no.3 (2019): 521 - 528. 10.5455/annalsmedres.2018.12.281
MLA	Kaya Yasin Emre An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. Annals of Medical Research, vol.26, no.3, 2019, ss.521 - 528. 10.5455/annalsmedres.2018.12.281
AMA	Kaya Y An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. Annals of Medical Research. 2019; 26(3): 521 - 528. 10.5455/annalsmedres.2018.12.281
Vancouver	Kaya Y An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury. Annals of Medical Research. 2019; 26(3): 521 - 528. 10.5455/annalsmedres.2018.12.281
IEEE	Kaya Y "An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury." Annals of Medical Research, 26, ss.521 - 528, 2019. 10.5455/annalsmedres.2018.12.281
ISNAD	Kaya, Yasin Emre. "An evaluation of gabapentin and pregabalin usage in the treatment of neuropathic pain related to spinal cord injury". Annals of Medical Research 26/3 (2019), 521-528. https://doi.org/10.5455/annalsmedres.2018.12.281