ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS
Yıl: 2018 Cilt: 7 Sayı: 2 Sayfa Aralığı: 196 - 206 Metin Dili: İngilizce DOI: 10.18036/aubtdc.349864 İndeks Tarihi: 24-12-2019
ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS
Öz: Quetiapine is an atypical antipsychotic drug used for treatments of patients with schizophrenia. Although hepatotoxic effectsrelated to quetiapine treatment were reported in a few studies, potential hepatotoxicity of this drug was not identified. Therefore,it was aimed to evaluate the possible hepatotoxic effects of quetiapine by oral administration of this drug at 10 and 20 mg/kgdoses to rats for 30 days in our study. For this purpose, plasma aspartate aminotransferase, alanine aminotransferase, totalbilirubin and direct bilirubin levels as markers of hepatotoxicity were determined and histopathological examination wasperformed in liver tissues. Additionally, we evaluated GSH levels in liver tissues. According to our results, serum aspartateaminotransferase and alanine aminotransferase levels were significantly increased in quetiapine-administered groups, whereastotal and direct bilirubin levels were significantly increased in the high dose group. Histopathological investigation of livertissue indicated that necrotic regions were present in 10 mg/kg quetiapine-administered group whereas prevalent necroticregions accompanying sinusoidal dilatation were observed in 20 mg/kg quetiapine-administered group. Otherwise, there is notany significant difference among groups in terms of GSH levels. According to these results, we concluded that quetiapinetreatment induced hepatotoxic effects in rats, dose-dependently.
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| APA | ILGIN S, BURUKOĞLU DÖNMEZ D, BAYSAL M, HINIS Ö, ATLI Ö (2018). ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. , 196 - 206. 10.18036/aubtdc.349864 |
| Chicago | ILGIN Sinem,BURUKOĞLU DÖNMEZ DİLEK,BAYSAL Merve,HINIS Özlem,ATLI Özlem ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. (2018): 196 - 206. 10.18036/aubtdc.349864 |
| MLA | ILGIN Sinem,BURUKOĞLU DÖNMEZ DİLEK,BAYSAL Merve,HINIS Özlem,ATLI Özlem ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. , 2018, ss.196 - 206. 10.18036/aubtdc.349864 |
| AMA | ILGIN S,BURUKOĞLU DÖNMEZ D,BAYSAL M,HINIS Ö,ATLI Ö ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. . 2018; 196 - 206. 10.18036/aubtdc.349864 |
| Vancouver | ILGIN S,BURUKOĞLU DÖNMEZ D,BAYSAL M,HINIS Ö,ATLI Ö ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. . 2018; 196 - 206. 10.18036/aubtdc.349864 |
| IEEE | ILGIN S,BURUKOĞLU DÖNMEZ D,BAYSAL M,HINIS Ö,ATLI Ö "ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS." , ss.196 - 206, 2018. 10.18036/aubtdc.349864 |
| ISNAD | ILGIN, Sinem vd. "ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS". (2018), 196-206. https://doi.org/10.18036/aubtdc.349864 |
| APA | ILGIN S, BURUKOĞLU DÖNMEZ D, BAYSAL M, HINIS Ö, ATLI Ö (2018). ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, 7(2), 196 - 206. 10.18036/aubtdc.349864 |
| Chicago | ILGIN Sinem,BURUKOĞLU DÖNMEZ DİLEK,BAYSAL Merve,HINIS Özlem,ATLI Özlem ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji 7, no.2 (2018): 196 - 206. 10.18036/aubtdc.349864 |
| MLA | ILGIN Sinem,BURUKOĞLU DÖNMEZ DİLEK,BAYSAL Merve,HINIS Özlem,ATLI Özlem ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, vol.7, no.2, 2018, ss.196 - 206. 10.18036/aubtdc.349864 |
| AMA | ILGIN S,BURUKOĞLU DÖNMEZ D,BAYSAL M,HINIS Ö,ATLI Ö ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji. 2018; 7(2): 196 - 206. 10.18036/aubtdc.349864 |
| Vancouver | ILGIN S,BURUKOĞLU DÖNMEZ D,BAYSAL M,HINIS Ö,ATLI Ö ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji. 2018; 7(2): 196 - 206. 10.18036/aubtdc.349864 |
| IEEE | ILGIN S,BURUKOĞLU DÖNMEZ D,BAYSAL M,HINIS Ö,ATLI Ö "ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS." Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, 7, ss.196 - 206, 2018. 10.18036/aubtdc.349864 |
| ISNAD | ILGIN, Sinem vd. "ASSESSMENT OF HEPATOTOXIC EFFECTS OF QUETIAPINE AT REPEATED DOSES IN RATS". Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji 7/2 (2018), 196-206. https://doi.org/10.18036/aubtdc.349864 |
