HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS
Yıl: 2018 Cilt: 7 Sayı: 2 Sayfa Aralığı: 220 - 226 Metin Dili: İngilizce DOI: 10.18036/aubtdc.364844 İndeks Tarihi: 24-12-2019
HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS
Öz: Cyclophosphamide is among anticancerous and immunosuppressing drugs frequently used in chemotherapy treatment.Cyclophosphamide is a chemotherapeutic agent but has also toxic effect on testes. Testicular cells can be protected from toxiceffects by antioxidant systems, including vitamin E. The aim of this study is to reveal what kind of effects the vit-E exerts uponexperimentally induced CP toxicity in testicular tissue of rats. Results of the present study indicate that the testicular injuryinduced by CP can be prevented by administration of vitamin E.
Anahtar Kelime: SIÇANLARDA SİKLOFOSFAMİDE BAĞLI TESTİS HASARINDA VİTAMİN E'NİN ROLÜNÜN HİSTOLOJİK OLARAK İNCELENMESİ
Öz: Siklofosfamid, kemoterapi tedavisinde sıklıkla kullanılan antikanser ve immünosüpresan ilaçlar arasındadır. Siklofosfamid kemoterapötik bir ajandır ancak testis üzerinde toksik etkiye sahiptir. Testis hücreleri, E vitamini gibi antioksidan sistemler ile bu toksik etkilerden korunabilir. Bu çalışmanın amacı, vit E'nin sıçanlarda testiküler doku üzerinde deneysel olarak uyarılan CP toksisitesine ne tür bir etki uyguladığını açığa çıkarmaktır. Bu çalışmanın sonuçları, CP ile indüklenen testikular hasarın vitamin E'nin verilmesiyle önlenebildiğini göstermektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Howell S, Shalet S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol. Metab. Clin. North. Am 1998; 27: 927–4.3
- Kayaalp O. Vitaminler, E vitamini, Rasyonel tedavi yönünden tıbbi farmakoloji. 1.baskı. Ankara Türkiye: Hacettepe-Taş Kitapçılık, 2009.
- Meistrich ML, Wilson G, Kangasniemi M. Mechanism of protection of rat spermatogenesis by hormonal pretreatment: stimulation of spermatogonyum l differentiation after irradiation. Journal of Andrology 2000; Vol 2.
- Papageorgio C, McLeod HL Chemoterapy: Principles and Pharmacology. The Washington Manual of Oncology Philadelphia, Lippincott, Williams-Wilkins, 2002.
- Estakhri R, Hajipour B, Majidi H, Soleimani H. Vitamin E ameliorates cyclophosphamide induced nephrotoxicity. Life Science Journal 2013;10:6.
- Nagel E, zu Vilsendorf AM, Bartels M, Pichlmayr R. Antioxidative vitamins in prevention of ischemia/reperfusion injury. Internat J Vit Nutr Res 1997; 67: 298-306.
- Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa II. Depletion of adenosine triphosphate plays an important role in the inhibition of sperm motility. J Androl 1992; 13: 379-386.
- Palamanda JR, Kehrer JR. Involvement of vitamin E and protein thiols in the inhibition of microsomal lipid peroxidation by glutathione. Lipids 1993; 28:427-431.
- Sarkar SD, Maiti R, Ghosh D. Management of fluoride induced testicular disorders by calcium and Vitamin-E co-administration in the albino rat, Reproductive Toxicology 2006; 22: 606-612.
- Chapman RM. Gonadal injury resulting from chemotherapy. Am J Indust Med 1983; 4:149-161.
- Rezvanfar MA, Sadrkhanlou RA, Ahmadi A, Shojaei-Sadee H. Protection of cyclophosphamideinduced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stres. Hum Exp Toxicol 2008; 27, 901.
- Laila ME. Sabik, Sahar S.Abd.El-Rahman. Alpha-tocopherol and ginger are protective on cyclophosphamide-induced gonadal toxicity in adult male albino rats. Basic and Applied Pathology 2009; 2: 21-29
- Hoda H Anan, Nashwa S Wahba, Maha A Abdallah, Dalia A Mohamed. Histological and immunohistochemical study of cyclophosphamide effect on adult rat testis. International Journal of Scientific Reports 2017; 3, 39-48.
- Aml F, Elgazar. Protective role of walnut seeds extract and vitamin E against testicular toxicity induced by cyclophosphamide in male rats. British Journal of Medicine & Medical Research 2016; 18: 1-10.
- Mohammad Afkhami-Ardakani, Shapour Hasanzadeh, Rasoul Shahrooz, Norouz Delirezh, Hassan Malekinejad. Antioxidant effects of Spirulina platensis (Arthrospira platensis) on cyclophosphamide-induced testicular injury in rats. Veterinary Research Forum 2018; 9: 35 – 41.
| APA | BURUKOĞLU DÖNMEZ D, YETİM İ (2018). HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. , 220 - 226. 10.18036/aubtdc.364844 |
| Chicago | BURUKOĞLU DÖNMEZ DİLEK,YETİM İnci HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. (2018): 220 - 226. 10.18036/aubtdc.364844 |
| MLA | BURUKOĞLU DÖNMEZ DİLEK,YETİM İnci HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. , 2018, ss.220 - 226. 10.18036/aubtdc.364844 |
| AMA | BURUKOĞLU DÖNMEZ D,YETİM İ HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. . 2018; 220 - 226. 10.18036/aubtdc.364844 |
| Vancouver | BURUKOĞLU DÖNMEZ D,YETİM İ HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. . 2018; 220 - 226. 10.18036/aubtdc.364844 |
| IEEE | BURUKOĞLU DÖNMEZ D,YETİM İ "HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS." , ss.220 - 226, 2018. 10.18036/aubtdc.364844 |
| ISNAD | BURUKOĞLU DÖNMEZ, DİLEK - YETİM, İnci. "HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS". (2018), 220-226. https://doi.org/10.18036/aubtdc.364844 |
| APA | BURUKOĞLU DÖNMEZ D, YETİM İ (2018). HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, 7(2), 220 - 226. 10.18036/aubtdc.364844 |
| Chicago | BURUKOĞLU DÖNMEZ DİLEK,YETİM İnci HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji 7, no.2 (2018): 220 - 226. 10.18036/aubtdc.364844 |
| MLA | BURUKOĞLU DÖNMEZ DİLEK,YETİM İnci HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, vol.7, no.2, 2018, ss.220 - 226. 10.18036/aubtdc.364844 |
| AMA | BURUKOĞLU DÖNMEZ D,YETİM İ HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji. 2018; 7(2): 220 - 226. 10.18036/aubtdc.364844 |
| Vancouver | BURUKOĞLU DÖNMEZ D,YETİM İ HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS. Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji. 2018; 7(2): 220 - 226. 10.18036/aubtdc.364844 |
| IEEE | BURUKOĞLU DÖNMEZ D,YETİM İ "HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS." Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji, 7, ss.220 - 226, 2018. 10.18036/aubtdc.364844 |
| ISNAD | BURUKOĞLU DÖNMEZ, DİLEK - YETİM, İnci. "HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS". Anadolu Üniversitesi Bilim ve Teknoloji Dergisi :C-Yaşam Bilimleri ve Biyoteknoloji 7/2 (2018), 220-226. https://doi.org/10.18036/aubtdc.364844 |
