Objective: Laparoscopic cholecystectomy is a minimally invasive surgical procedure but it is stillassociated with postoperative pain within the first 24 hours. Ultrasound-guided transversusabdominis plane block is a regional anesthetic technique which provides postoperative analgesiain abdominal surgery. We aimed to determine the effects of the TAP block on discharge time,non-opioid and opioid consumption, shoulder tip pain, incidence of postoperative nausea andvomiting, and severity of pain evaluated with visual analogue scale in patients who underwentlaparoscopic cholecystectomy.Methods: Seventy-two eligible patients who underwent laparoscopic cholecystectomy wereincluded in the study. In 38 patients ultrasound-guided TAP block was performed, and 34 patientswere treated with conventional methods such as non-steroid anti-inflamatory drugs. Data relatedto VAS pain scores, shoulder tip pain, intraoperative opioid consumption, postoperative non-opioid and opioid consumption, nausea vomiting and discharge time were collected retrospec-tively to determine statistically significant differences between TAP block and non-TAP blockgroups.Results: VAS pain scores were globally reduced at all time periods in two groups (significantgroup main effect, F(7.760)=94.47, P<0.001). VAS pain scores were significantly lower at all mea-surement intervals except 24h in the TAP group than in the non-TAP group. Shoulder pain wassignificantly higher in TAP block group than non-TAP block group (p<0.001). Any statistically sig-nificant difference was not found between the groups in terms of intraoperative, and postopera-tive opioid consumption, discharge time, nausea and vomiting.Conclusion: Ultrasound-guided TAP block is an effective regional analgesic technique to decreasepostoperative abdominal pain, however TAP block does not reduce shoulder tip pain. Multimodalpain management is required after laparoscopic cholecystectomy.