Evaluation of macula, optic nerve and choroid in children with joint hypermobility
Yıl: 2019 Cilt: 26 Sayı: 7 Sayfa Aralığı: 1271 - 1274 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.03.126 İndeks Tarihi: 06-01-2020
Evaluation of macula, optic nerve and choroid in children with joint hypermobility
Öz: Aim: To evaluate the macula, optic nerve and choroid layer by using Spectral Domain (SD)-OCT in children with joint hypermobility(JH)Material and Methods: In this cross-sectional case control study, 25 eyes of 25 children with JH diagnosed by rheumatologicalexamination and 37 eyes of 37 healthy children were evaluated. Images were taken with SD -OCT. Two groups were compared interms of mean central macular thickness, macular volume, ganglion cell complex (GCC) thickness, retina nerve fiber layer (RNFL)thickness and choroidal thickness (CT). CT was measured at the fovea; other CT measurements were taken 1,000 μm away from thefovea at the nasal and temporal regions and 1000 μm away from the optic disc at the nasal and temporal regions.Results: Mean subfoveal CT was 293.85±40.74 μm in JH group and 301.66±49.47 μm in the control group (p=0.548). There was nosignificant difference regarding to the mean macular and peripapillary CT values of all regions (P >0 .05 for all points). Moreover, themean thicknesses of the RNFL, macula, and GCC did not differ between the two groups.Conclusion: This study showed that CT of children with JH is similar to those of healthy controls. In addition, there was no differencein macular thickness, RNFL and GCC between the two groups. These findings suggest that posterior segment structures are notaffected in individuals with JH.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Grahame R, Bird HA, Child A. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol 2000;27:1777-9.
- 2. Grahame R, Hakim AJ. Hypermobility. Curr Opinion Rheumatol 2008;20:106-10.
- 3. El-Garf A, Mahmoud G, Mahgoub E. Hypermobility among Egyptian children: prevalence and features. J Rheumatol 1998;25:1003-5.
- 4. Harreby M, Nygaard B, Jessen T, et al. Risk factors for low back pain in a cohort of 1389 Danish school children: an epidemiologic study. Eur Spine J 1999;8:444-50.
- 5. Qvindesland A, Jonsson H. Articular hypermobility in Icelandic 12-year-olds. Rheumatol (Oxford) 1999;38:1014- 6.
- 6. Rikken-Bultman DG, Wellink L, van Dongen PW. Hypermobility in two Dutch school poulations. Eur J Obstet Gynecol Reprod Biol 1997;73:189-92.
- 7. Subramanyam V, Janaki K. Joint hypermobility in south Indian children. Indian Pediatr 1996;33:771-2.
- 8. Engelbert RH, Bank RA, Sakkers RJ, et al. Pediatric generalized joint hypermobility with and without musculoskeletal complaints: a localized or systemic disorder? Pediatrics 2003;111:e248-e54.
- 9. Cameron JA. Corneal abnormalities in Ehlers-Danlos syndrome type VI. Cornea 1993;12:54-9.
- 10. Gharbiya M, Moramarco A, Castori M, et al. Ocular features in joint hypermobility Syndrome/Ehlers-Danlos syndrome hypermobility type: a clinical and in vivo Confocal Microscopy Study. Am J Ophthalmol 2012;154:593-600.e1.
- 11. Green W, Friedman-Kien A, Banfield W. Angioid streaks in Ehlers-Danlos syndrome. Arc Ophthalmol 1966;76:197-204.
- 12. Segev F, Héon E, Cole WG, et al. Structural abnormalities of the cornea and lid resulting from collagen V mutations. Invest Ophthalmol Vis Sci 2006;47:565-73.
- 13. Whitaker JK, Alexander P, Chau DY, et al. Severe conjunctivochalasis in association with classic type Ehlers- Danlos syndrome. BMC Ophthalmol 2012;12:47.
- 14. Meek KM, Boote C. The organization of collagen in the corneal stroma. Exp Eye Res 2004;78:503-12.
- 15. Marshall G, Konstas A, Lee W. Collagens in ocular tissues. Br J Ophthalmol 1993;77:515-24.
- 16. Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography. Invest Ophthalmol Visual Sci 2009;50:3876- 80.
- 17. Fikree A, Aziz Q, Grahame R. Joint hypermobility syndrome. Rheum Dis Clin North Am 2013;39:419-30.
- 18. Spaide RF, Koizumi H, Pozonni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008;146:496-500.
- 19. Snead M, McNinch A, Poulson A, et al. Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthalmologist. Eye (Lond) 2011;25:1389-400.
- 20. Halfter W, Winzen U, Bishop PN, et al. Regulation of eye size by the retinal basement membrane and vitreous body. Invest Ophthalmol Vis Sci 2006;47:3586-94.
- 21. Malfait F, Hakim A, De Paepe A, et al. The genetic basis of the joint hypermobility syndromes. Rheumatology 2006;45:502- 7.
- 22. Seçkin Ü, Tur BS, Yılmaz Ö, et al. The prevalence of joint hypermobility among high school students. Rheumatol Int 2005;25:260-3.
- 23. Alm A, Bill A. Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues. Exp Eye Res 1973;15:15-29.
- 24. Kang HM, Lee CS, Lee SC. Thinner subfoveal choroidal thickness in eyes with ocular ischemic syndrome than in unaffected contralateral eyes. Graefes Arch for Clin Exp Ophthalmol 2014;252:851.
- 25. Demircan A, Altan C, Osmanbasoglu OA, et al. Subfoveal choroidal thickness measurements with enhanced depth imaging optical coherence tomography in patients with nanophthalmos. Br J Ophthalmol 2014;98:345-9.
- 26. Hosoda Y, Uji A, Hangai M, et al. Relationship between retinal lesions and inward choroidal bulging in Vogt-Koyanagi- Harada disease. Am J Ophthalmol 2014;157:1056-63.e1.
- 27. Gemenetzi M, De Salvo G, Lotery A. Central serous chorioretinopathy: an update on pathogenesis and treatment. Eye (Lond) 2010;24:1743-56.
- 28. Koizumi H, Yamagishi T, Yamazaki T, et al. Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol 2011;249:1123-8.
- 29. Mishra MB, Ryan P, Atkinson P, et al. Extra-articular features of benign joint hypermobility syndrome. Br J Rheumatol 1996;35:861-6.
| APA | Bayramoğlu S, Ekinci D, Sayin N, AKTAY AYAZ N, Çakan M (2019). Evaluation of macula, optic nerve and choroid in children with joint hypermobility. , 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| Chicago | Bayramoğlu Sadık Etka,Ekinci Dilbade yildiz,Sayin Nihat,AKTAY AYAZ Nuray,Çakan Mustafa Evaluation of macula, optic nerve and choroid in children with joint hypermobility. (2019): 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| MLA | Bayramoğlu Sadık Etka,Ekinci Dilbade yildiz,Sayin Nihat,AKTAY AYAZ Nuray,Çakan Mustafa Evaluation of macula, optic nerve and choroid in children with joint hypermobility. , 2019, ss.1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| AMA | Bayramoğlu S,Ekinci D,Sayin N,AKTAY AYAZ N,Çakan M Evaluation of macula, optic nerve and choroid in children with joint hypermobility. . 2019; 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| Vancouver | Bayramoğlu S,Ekinci D,Sayin N,AKTAY AYAZ N,Çakan M Evaluation of macula, optic nerve and choroid in children with joint hypermobility. . 2019; 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| IEEE | Bayramoğlu S,Ekinci D,Sayin N,AKTAY AYAZ N,Çakan M "Evaluation of macula, optic nerve and choroid in children with joint hypermobility." , ss.1271 - 1274, 2019. 10.5455/annalsmedres.2019.03.126 |
| ISNAD | Bayramoğlu, Sadık Etka vd. "Evaluation of macula, optic nerve and choroid in children with joint hypermobility". (2019), 1271-1274. https://doi.org/10.5455/annalsmedres.2019.03.126 |
| APA | Bayramoğlu S, Ekinci D, Sayin N, AKTAY AYAZ N, Çakan M (2019). Evaluation of macula, optic nerve and choroid in children with joint hypermobility. Annals of Medical Research, 26(7), 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| Chicago | Bayramoğlu Sadık Etka,Ekinci Dilbade yildiz,Sayin Nihat,AKTAY AYAZ Nuray,Çakan Mustafa Evaluation of macula, optic nerve and choroid in children with joint hypermobility. Annals of Medical Research 26, no.7 (2019): 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| MLA | Bayramoğlu Sadık Etka,Ekinci Dilbade yildiz,Sayin Nihat,AKTAY AYAZ Nuray,Çakan Mustafa Evaluation of macula, optic nerve and choroid in children with joint hypermobility. Annals of Medical Research, vol.26, no.7, 2019, ss.1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| AMA | Bayramoğlu S,Ekinci D,Sayin N,AKTAY AYAZ N,Çakan M Evaluation of macula, optic nerve and choroid in children with joint hypermobility. Annals of Medical Research. 2019; 26(7): 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| Vancouver | Bayramoğlu S,Ekinci D,Sayin N,AKTAY AYAZ N,Çakan M Evaluation of macula, optic nerve and choroid in children with joint hypermobility. Annals of Medical Research. 2019; 26(7): 1271 - 1274. 10.5455/annalsmedres.2019.03.126 |
| IEEE | Bayramoğlu S,Ekinci D,Sayin N,AKTAY AYAZ N,Çakan M "Evaluation of macula, optic nerve and choroid in children with joint hypermobility." Annals of Medical Research, 26, ss.1271 - 1274, 2019. 10.5455/annalsmedres.2019.03.126 |
| ISNAD | Bayramoğlu, Sadık Etka vd. "Evaluation of macula, optic nerve and choroid in children with joint hypermobility". Annals of Medical Research 26/7 (2019), 1271-1274. https://doi.org/10.5455/annalsmedres.2019.03.126 |
