Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats
Yıl: 2019 Cilt: 36 Sayı: 5 Sayfa Aralığı: 270 - 275 Metin Dili: İngilizce DOI: 10.4274/balkanmedj.galenos.2019.2019.2.61 İndeks Tarihi: 22-01-2020
Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats
Öz: Background: Chemerin is a recently discovered adipokine that plays a role in adipocyte metabolism. It is a novel chemoattractant adipokine whose expression and secretion are increased by adipogenesis.Aims: To evaluate the effects of probiotic supplementation on chemerin level, inflammation, and metabolic syndrome components in obese Wistar rats.Study Design: Animal experiment.Methods: We divided the experimental animals into three groups, each consisting of eight rats. Group 1 was the control group. Group 2 was the experimentally obese group, in which rats were fed with a high-fat diet. Group 3 was the obese intervention group, in which rats were supplemented with probiotics after obesity induction.Results: At the end of the study, a statistically significant difference was found between the groups in final weights, weight changes, and body mass index values (p<0.05). Weight gain was 34.12±3.70 g in group 3 post-probiotic supplementation and 53.25±8.35 g in group 2 (p<0.05). Obese rats showed increased levels of fasting plasma glucose, insulin, insulin resistance (homeostatic model assessment-insulin resistance), total cholesterol, low-density lipoprotein cholesterol, inflammatory markers, and leptin compared to those in the control group. Chemerin levels were 14.31±13.34 ng/mL in group 2 and 2.67±2.42 ng/mL in group 3 (p<0.05).Conclusion: Probiotic supplementation (group 3) reduced weight gain, and there were positive effects on the levels of fasting plasma glucose, insulin, homeostatic model assessment-insulin resistance, triglycerides, inflammatory markers, leptin, and chemerin.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet 2016;387:1377-96.
- NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet 2017;390:2627-42.
- Carvalho BM, Guadagnini D, Tsukumo DML, Schenka AA, Latuf-Filho P, Vassallo J, et al. Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice. Diabetologia 2012;55:2823-34.
- Gomes AC, Bueno AA, de Souza RG, Mota JF. Gut microbiota, probiotics and diabetes. Nutr J 2014;13:60.
- Kootte RS, Vrieze A, Holleman F, Dallinga-Thie GM, Zoetendal EG, de Vos WM, et al. The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes Metab 2012;14:112-20.
- Sanchez M, Darimont C, Panahi S, Drapeau V, Marette A, Taylor VH, et al. Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals. Nutrients 2017;9. pii: E284.
- Sonnenburg JL, Bäckhed F. Diet-microbiota interactions as moderators of human metabolism. Nature 2016;535:56-64.
- Bäckhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci 2004;101:15718-23.
- Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006;444:1027-31.
- Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem 2007;282:28175-88.
- Piya MK, McTernan PG, Kumar S. Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin. J Endocrinol 2013;216:T1-15.
- Chang SS, Eisenberg D, Zhao L, Adams C, Leib R, Morser J, et al. Chemerin activation in human obesity. Obesity (Silver Spring) 2016;24:1522-9.
- Ernst MC, Issa M, Goralski KB, Sinal CJ. Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. Endocrinology 2010;151:1998-2007.
- Ernst MC, Sinal CJ. Chemerin: at the crossroads of inflammation and obesity. Trends Endocrinol Metab 2010;21:660-7.
- Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, et al. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology 2007;148:4687-94.
- Fatima SS, Bozaoglu K, Rehman R, Alam F, Memon AS. Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes. PLoS One 2013;8:e57113.
- Sell H, Divoux A, Poitou C, Basdevant A, Bouillot JL, Bedossa P, et al. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatric surgery. J Clin Endocrinol Metab 2010;95:2892-6.
- Li Y, Shi B, Li S. Association between serum chemerin concentrations and clinical indices in obesity or metabolic syndrome: a meta-analysis. PLoS One 2014;9:e113915.
- Wassink AM, Olijhoek JK, Visseren FL. The metabolic syndrome: metabolic changes with vascular consequences. Eur J Clin Invest 2007;37:8-17.
- Novelli EL, Diniz YS, Galhardi CM, Ebaid GM, Rodrigues HG, Mani F, et al. Anthropometrical parameters and markers of obesity in rats. Lab Anim 2007;41:111-9.
- Bagarolli RA, Tobar N, Oliveira AG, Araújo TG, Carvalho BM, Rocha GZ, et al. Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice. J Nutr Biochem 2017;50:16-25.
- Desmarchelier C, Ludwig T, Scheundel R, Rink N, Bader BL, Klingenspor M, et al. Diet-induced obesity in ad libitum-fed mice: food texture overrides the effect of macronutrient composition. Br J Nutr 2013;109:1518-27.
- Cohen J. Statistical power analysis for the behavioral sciences: Routledge; 2013.
- Lamont BJ, Waters MF, Andrikopoulos S. A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice. Nutr Diabetes 2016;6:e194.
- Qin L, Zhao Y, Zhang B, Li Y. Amentoflavone improves cardiovascular dysfunction and metabolic abnormalities in high fructose and fat diet-fed rats. Food Funct 2018;9:243-52.
- Lecomte V, Kaakoush NO, Maloney CA, Raipuria M, Huinao KD, Mitchell HM, et al. Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters. PLoS One 2015;10:e0126931.
- Nunez IN, Galdeano CM, de LeBlanc Ade M, Perdigon G. Evaluation of immune response, microbiota, and blood markers after probiotic bacteria administration in obese mice induced by a high-fat diet. Nutrition 2014;30:1423-32. Mihailović M, Živković M, Jovanović J, Tolinački M, Sinadinović M, Rajić J, et al. Oral administration of probiotic Lactobacillus paraplantarum BGCG11 attenuates diabetes-induced liver and kidney damage in rats. J Funct Foods 2017;38:427-37.
- Shin JH, Nam MH, Lee H, Lee JS, Kim H, Chung MJ, et al. Amelioration of obesity-related characteristics by a probiotic formulation in a high-fat diet-induced obese rat model. Eur J Nutr 2018;57:2081-90.
- Kang JH, Yun SI, Park HO. Effects of Lactobacillus gasseri BNR17 on body weight and adipose tissue mass in diet-induced overweight rats. J Microbiol 2010;48:712-4.
- Shirouchi B, Nagao K, Umegatani M, Shiraishi A, Morita Y, Kai S, et al. Probiotic Lactobacillus gasseri SBT2055 improves glucose tolerance and reduces body weight gain in rats by stimulating energy expenditure. Br J Nutr 2016;116:451-8.
- Chang CJ, Lu CC, Lin CS, Martel J, Ko YF, Ojcius DM, et al. Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. Int J Obes (Lond) 2018;42:231-43.
- Karimi G, Jamaluddin R, Mohtarrudin N, Ahmad Z, Khazaai H, Parvaneh M. Single-species versus dual-species probiotic supplementation as an emerging therapeutic strategy for obesity. Nutr Metab Cardiovasc Dis 2017;27:910-8.
- Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, et al. Chemerin a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun 2007;362:1013-8.
- Lloyd JW, Zerfass KM, Heckstall EM, Evans KA. Diet-induced increases in chemerin are attenuated by exercise and mediate the effect of diet on insulin and HOMA-IR. Ther Adv Endocrinol Metab 2015;6:189-98.
- Ress C, Tschoner A, Engl J, Klaus A, Tilg H, Ebenbichler CF, et al. Effect of bariatric surgery on circulating chemerin levels. Eur J Clin Invest 2010;40:277-80.
| APA | ÇELİK M, ÜNLÜ SÖĞÜT M (2019). Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. , 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| Chicago | ÇELİK MENŞURE NUR,ÜNLÜ SÖĞÜT Mehtap Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. (2019): 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| MLA | ÇELİK MENŞURE NUR,ÜNLÜ SÖĞÜT Mehtap Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. , 2019, ss.270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| AMA | ÇELİK M,ÜNLÜ SÖĞÜT M Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. . 2019; 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| Vancouver | ÇELİK M,ÜNLÜ SÖĞÜT M Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. . 2019; 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| IEEE | ÇELİK M,ÜNLÜ SÖĞÜT M "Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats." , ss.270 - 275, 2019. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| ISNAD | ÇELİK, MENŞURE NUR - ÜNLÜ SÖĞÜT, Mehtap. "Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats". (2019), 270-275. https://doi.org/10.4274/balkanmedj.galenos.2019.2019.2.61 |
| APA | ÇELİK M, ÜNLÜ SÖĞÜT M (2019). Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. Balkan Medical Journal, 36(5), 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| Chicago | ÇELİK MENŞURE NUR,ÜNLÜ SÖĞÜT Mehtap Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. Balkan Medical Journal 36, no.5 (2019): 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| MLA | ÇELİK MENŞURE NUR,ÜNLÜ SÖĞÜT Mehtap Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. Balkan Medical Journal, vol.36, no.5, 2019, ss.270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| AMA | ÇELİK M,ÜNLÜ SÖĞÜT M Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. Balkan Medical Journal. 2019; 36(5): 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| Vancouver | ÇELİK M,ÜNLÜ SÖĞÜT M Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats. Balkan Medical Journal. 2019; 36(5): 270 - 275. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| IEEE | ÇELİK M,ÜNLÜ SÖĞÜT M "Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats." Balkan Medical Journal, 36, ss.270 - 275, 2019. 10.4274/balkanmedj.galenos.2019.2019.2.61 |
| ISNAD | ÇELİK, MENŞURE NUR - ÜNLÜ SÖĞÜT, Mehtap. "Probiotics Improve Chemerin Levels and Metabolic Syndrome Parameters in Obese Rats". Balkan Medical Journal 36/5 (2019), 270-275. https://doi.org/10.4274/balkanmedj.galenos.2019.2019.2.61 |
