Introduction and objectives: Skin cancers are one of the most common cancers. These cancers are usually examined under two groups as non-melanomas and melanomas, and most nonmelanomas are . The incidence and mortality rates of skin cancers are increasing all over the world. In this study, we want to investigated the intracellular antioxidants such as superoxide dismutase (SOD), catalase (CAT), reductase glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx) and malondialdehyde (MDA) values, which are oxidative stress markers, in skin cancer patients Material and method: The prospective study was carried out according to the modified World Helsinki Declaration. This study was done in the dermatology department of the university hospital. Thirty skin cancer patients and 30 healthy volunteers were included in the study. Intracellular antioxidants and levels of malondialdehyde were evaluated of participants in the study Results: The study consisted of 33 men (55%) and 27 women (45%). There was no significant difference between the age and gender variables of the study participants according to the patient and control group (p>0.05). The difference between GPx, GR, GSH, SOD, MDA, CAT values, patient and control group averages were statistically significant (p<0.05). Conclusion: This study has shown that antioxidant serum levels are decreased in skin cancer patients and MDA, an oxidative stress marker, is high.