Antifungal Activity of Some Benzimidazole-Hydrazones
Yıl: 2019 Cilt: 40 Sayı: 3 Sayfa Aralığı: 695 - 699 Metin Dili: İngilizce DOI: 10.17776/csj.579734 İndeks Tarihi: 30-01-2020
Antifungal Activity of Some Benzimidazole-Hydrazones
Öz: In the present work, 15 4-(1-(prop-2-in-1-yl)-1H-benzoimidazole-2-yl)-N'-(substitutedmethylene)benzohydrazide derivatives (4a-4o) were re-synthesized to evaluate their antifungal activity. Structure identification of synthesized compounds was elucidated by 1H-NMR, 13C-NMR, and HRMS spectroscopic methods. Inhibitory potential of the re-synthesized compounds was investigated against Candida supp. The compounds 4e and 4l showed significant anti fungal activity. Consistent with the activity studies, 4e was found to be potent derivative with its MIC50 value of (1.95 μg/mL) against Candida glabrata. And 4l was found to be potent derivative with its MIC50 value of (1.95 μg/mL) against Candida krusei.
Anahtar Kelime: Bazı Benzimidazol-Hidrazonların Antifungal Etkinliği
Öz: Mevcut çalışmada, 15 4-(1-(prop-2-in-1-il)-1H-benzimidazol-2-il)-N’-(sübstitüemetilen) benzohidrazit türevleri (4a-4o), antifungal aktivitelerini değerlendirmek üzere yeniden sentezlendi. Sentezlenen bileşiklerin yapı tanımlamaları 1H-NMR, 13C-NMR ve HRMS spektroskopik yöntemlerle açıklandı. Yeniden sentezlenen bileşiklerin antifungal etkinlikleri Candida türlerine karşı değerlendirildi. Bileşik 4e ve 4l önemli aktivite gösterdi. Aktivite çalışmaları ile uyumlu olarak, 4e bileşiği Candida glabrata'ya karşı 1.95 μg / mL MIC50 değeri ile güçlü bir türev olarak bulundu. Aynı zamanda 4l bileşiği Candida krusei’ye karşı 1.95 μg / mL MIC50 değeri ile güçlü bir türev olarak bulundu.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ACAR ÇEVİK U, OSMANİYE D (2019). Antifungal Activity of Some Benzimidazole-Hydrazones. , 695 - 699. 10.17776/csj.579734 |
| Chicago | ACAR ÇEVİK ULVİYE,OSMANİYE DERYA Antifungal Activity of Some Benzimidazole-Hydrazones. (2019): 695 - 699. 10.17776/csj.579734 |
| MLA | ACAR ÇEVİK ULVİYE,OSMANİYE DERYA Antifungal Activity of Some Benzimidazole-Hydrazones. , 2019, ss.695 - 699. 10.17776/csj.579734 |
| AMA | ACAR ÇEVİK U,OSMANİYE D Antifungal Activity of Some Benzimidazole-Hydrazones. . 2019; 695 - 699. 10.17776/csj.579734 |
| Vancouver | ACAR ÇEVİK U,OSMANİYE D Antifungal Activity of Some Benzimidazole-Hydrazones. . 2019; 695 - 699. 10.17776/csj.579734 |
| IEEE | ACAR ÇEVİK U,OSMANİYE D "Antifungal Activity of Some Benzimidazole-Hydrazones." , ss.695 - 699, 2019. 10.17776/csj.579734 |
| ISNAD | ACAR ÇEVİK, ULVİYE - OSMANİYE, DERYA. "Antifungal Activity of Some Benzimidazole-Hydrazones". (2019), 695-699. https://doi.org/10.17776/csj.579734 |
| APA | ACAR ÇEVİK U, OSMANİYE D (2019). Antifungal Activity of Some Benzimidazole-Hydrazones. Cumhuriyet Science Journal, 40(3), 695 - 699. 10.17776/csj.579734 |
| Chicago | ACAR ÇEVİK ULVİYE,OSMANİYE DERYA Antifungal Activity of Some Benzimidazole-Hydrazones. Cumhuriyet Science Journal 40, no.3 (2019): 695 - 699. 10.17776/csj.579734 |
| MLA | ACAR ÇEVİK ULVİYE,OSMANİYE DERYA Antifungal Activity of Some Benzimidazole-Hydrazones. Cumhuriyet Science Journal, vol.40, no.3, 2019, ss.695 - 699. 10.17776/csj.579734 |
| AMA | ACAR ÇEVİK U,OSMANİYE D Antifungal Activity of Some Benzimidazole-Hydrazones. Cumhuriyet Science Journal. 2019; 40(3): 695 - 699. 10.17776/csj.579734 |
| Vancouver | ACAR ÇEVİK U,OSMANİYE D Antifungal Activity of Some Benzimidazole-Hydrazones. Cumhuriyet Science Journal. 2019; 40(3): 695 - 699. 10.17776/csj.579734 |
| IEEE | ACAR ÇEVİK U,OSMANİYE D "Antifungal Activity of Some Benzimidazole-Hydrazones." Cumhuriyet Science Journal, 40, ss.695 - 699, 2019. 10.17776/csj.579734 |
| ISNAD | ACAR ÇEVİK, ULVİYE - OSMANİYE, DERYA. "Antifungal Activity of Some Benzimidazole-Hydrazones". Cumhuriyet Science Journal 40/3 (2019), 695-699. https://doi.org/10.17776/csj.579734 |
