TY  - JOUR
TI  - Antifungal Activity of Some Benzimidazole-Hydrazones
AB  - In the present work, 15 4-(1-(prop-2-in-1-yl)-1H-benzoimidazole-2-yl)-N'-(substitutedmethylene)benzohydrazide derivatives (4a-4o) were re-synthesized to evaluate their antifungal activity. Structure identification of synthesized compounds was elucidated by 1H-NMR, 13C-NMR, and HRMS spectroscopic methods. Inhibitory potential of the re-synthesized compounds was investigated against Candida supp. The compounds 4e and 4l showed significant anti fungal activity. Consistent with the activity studies, 4e was found to be potent derivative with its MIC50 value of (1.95 μg/mL) against Candida glabrata. And 4l was found to be potent derivative with its MIC50 value of (1.95 μg/mL) against Candida krusei.
AU  - OSMANİYE, DERYA
AU  - ACAR ÇEVİK, ULVİYE
DO  - 10.17776/csj.579734
PY  - 2019
JO  - Cumhuriyet Science Journal
VL  - 40
IS  - 3
SN  - 2587-2680
SP  - 695
EP  - 699
DB  - TRDizin
UR  - http://search/yayin/detay/320311
ER  -