Transgender people are more vulnerable and at risk in terms of certain diseases. These people are more hesitant on health protection and cannot benefit from health care services for various reasons. Nurses should raise these people’s awareness on hormone usage, the ways of protection from sexually transmitted diseases, the importance of early diagnosis in the prevention of cancer, the prevention of risky behaviors such as smoking, alcohol and substance use, and the ways of protection from depression by taking part in trainings related to the health of transgender people. Nurses should help to improve the quality of life of the people by making these patients feel that the nurses are away from prejudice during the entire care process. In this article, the relevant literature and research findings on transsexual people’s attitudes towards protecting their health and the responsibilities of the nurses in this regard were examined and discussed, and application-oriented suggestions were offered.