TY  - JOUR
TI  - Design, Synthesis and Evaluation of the Biological Activities of Some New Carbohydrazide and Urea Derivatives
AB  - Objectives: Urea and carbohydrazide derivatives are important compounds exhibiting cytotoxic activities. In this study, a series of new urea andcarbohydrazide derivatives containing an pyridine ring were synthesized and evaluated for cytotoxic activity.Materials and Methods: The proposed structures of the synthesized compounds were confirmed using elemental analysis, IR, and 1H-NMRspectroscopic techniques. The cytotoxic potencies of synthesized compounds were determined using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT) on BRCA mutant-carrying HCC1937 and Capan-1 cell lines, as well as on MCF7, HeLa, and MRC5 cells.Results: 3a, 3b, 3c and 3d showed cytotoxic activity against all cancer cell lines.Conclusion: Our data indicate that compounds 3a-d are more selective to cancer cells compared with nontumoral fibroblasts; however, thesecompounds are not more potent on HR defective cells with BRCA mutants.
AU  - BALLAR KIRMIZIBAYRAK, PETEK
AU  - İLHAN, RECEP
AU  - GÜNAL, Selin
AU  - Tok, Fatih
AU  - KOÇYİĞİT KAYMAKÇIOĞLU, Bedia
DO  - 10.4274/tjps.64935
PY  - 2018
JO  - Turkish Journal of Pharmaceutical Sciences
VL  - 15
IS  - 3
SN  - 1304-530X
SP  - 304
EP  - 308
DB  - TRDizin
UR  - http://search/yayin/detay/324908
ER  -