Objective: The aim of present study was to determine the effects of factors todiabetic regulation; such as, awareness of the disease, compliance with treatment,awareness of HbA1c target, in T2DM patients whom followed up in our clinic.Methods: Patients with T2DM were enrolled to this retrospective study. Patient‘sdata were obtained and recorded from institutional database. As well as bloodpressure, anthropometric measurements, physical examination signs, andlaboratory parameters were recorded. Study population grouped into twoaccording to HbA1c level; well-regulated T2DM group with a HbA1c lower than8% and poorly-controlled T2DM group with a HbA1c 8% or greater.Results: A total of 150 patients with T2DM (72 men and 78 women) enrolled.Waist circumference, body mass index, duration of diabetes, LDL-cholesterol ,total cholesterol, triglyceride and serum creatinine were significantly lower inwell-controlled compared to poorly-controlled diabetic subjects (all p<0.05). Rateof well-regulated subjects was higher in patients living in urban compared tosubjects living in rural area (p=0.01). Diabetic regulation rate was significantlyhigher in patients acknowledge the diabetic medications, in self-monitoring bloodglucose, in subjects aware of HbA1c target, and free of diabetic complications;neuropathy, nephropathy, and diabetic foot (all p<0.05).Conclusions: Striking result of present study is that most important factorsassociated with better diabetic control were self monitoring of blood glucose,awareness of treatment target and acknowledgement of the diabetic medications;which all could be achieved by education and participation of the patient to thetherapeutic process.