Yıl: 2018 Cilt: 5 Sayı: 2 Sayfa Aralığı: 163 - 168 Metin Dili: İngilizce DOI: 10.14744/nci.2017.69379 İndeks Tarihi: 26-02-2020

Underlying factors of recurrent infections in patients with down syndrome

Öz:
Down syndrome is the most common chromosomal aberration. Patientswith Down syndrome suffer more infections thanthose without the disease. Underlying immunological disorders are consideredto be the reason for the increasing frequency ofinfections in patients with Down syndrome. In addition, some anatomical abnormalities in the respiratory tractaccompanyingDown syndrome can disturb the innate immunity and contribute to the increase in infection rate. Respiratory tract infectionsare one of the most common causes of mortality in patients with Down syndrome. Awareness of the underlying reason forfrequent respiratory tract infections should result in a decrease in mortality among these patients and contribute to an improvementintheir quality of life.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • Acar M, Zorlu P, Tos T, Koca SB, Senel S. Evaluation of demographic and clinical features of patients with down syndrome: Single center experience. Turkish Journal of Pediatric Disease 2014;8:71–4.
  • Watts R, Vyas H. An overview of respiratory problems in children with Down’s syndrome. Arch Dis Child 2013;98:812–7.
  • Ram G, Chinen J. Infections and immunodeficiency in Down syndrome. Clin Exp Immunol 2011;164:9–16.
  • Bloemers BL, Broers CJ, Bont L, Weijerman ME, Gemke RJ, van Furth AM. Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system. Microbes Infect 2010;12:799–808.
  • Stagliano DR, Nylund CM, Eide MB, Eberly MD. Children with Down syndrome are high-risk for severe respiratory syncytial virus disease. J Pediatr 2015;166:703–9.e2.
  • Mori M, Morio T, Ito S, Morimoto A, Ota S, Mizuta K, et al. Risks and prevention of severe RS virus infection among children with immunodeficiency and Down’s syndrome. J Infect Chemother 2014;20:455–9.
  • Yi H, Lanctôt KL, Bont L, Bloemers BL, Weijerman M, Broers C, et al. Respiratory syncytial virus prophylaxis in Down syndrome: a prospective cohort study. Pediatrics 2014;133:1031–7.
  • Garrison MM, Jeffries H, Christakis DA. Risk of death for children with down syndrome and sepsis. J Pediatr 2005;147:748–52.
  • Bertrand P, Navarro H, Caussade S, Holmgren N, Sánchez I. Airway anomalies in children with Down syndrome: endoscopic findings. Pediatr Pulmonol 2003;36:137–41.
  • Mitchell RB, Call E, Kelly J. Diagnosis and therapy for airway obstruction in children with Down syndrome. Arch Otolaryngol Head Neck Surg 2003;129:642–5.
  • de Jong AL, Sulek M, Nihill M, Duncan NO, Friedman EM. Tenuous airway in children with trisomy 21. Laryngoscope 1997;107:345–50.
  • McLaughlin FJ, Strieder DJ, Harris GB, Vawter GP, Eraklis AJ. Tracheal bronchus: association with respiratory morbidity in childhood. J Pediatr 1985;106:751–5.
  • Unal E, Oran B, Baysal T, Baspinar O, Keser M, Karaarslan S, et al. Pulmonary arterial pressure in infants with laryngomalacia. Int J Pediatr Otorhinolaryngol 2006;70:2067–71.
  • McDowell KM, Craven DI. Pulmonary complications of Down syndrome during childhood. J Pediatr 2011;158:319–25.
  • Biko DM, Schwartz M, Anupindi SA, Altes TA. Subpleural lung cysts in Down syndrome: prevalence and association with coexisting diagnoses. Pediatr Radiol 2008;38:280–4.
  • Irving CA, Chaudhari MP. Cardiovascular abnormalities in Down’s syndrome: spectrum, management and survival over 22 years. Arch Dis Child 2012;97:326–30.
  • Faria PF, Nicolau JA, Melek MZ, de Oliveira Nde S, Bermudez BE, Nisihara RM. Association between congenital heart defects and severe infections in children with Down syndrome. Rev Port Cardiol 2014;33:15–8.
  • Chin CJ, Khami MM, Husein M. A general review of the otolaryngologic manifestations of Down Syndrome. Int J Pediatr Otorhinolaryngol 2014;78:899–904.
  • Strome M. Down’s syndrome: a modern otorhinolaryngological perspective. Laryngoscope 1981;91:1581–94.
  • Shott SR. Down syndrome: common otolaryngologic manifestations. Am J Med Genet C Semin Med Genet 2006;142C:131–40.
  • Barr E, Dungworth J, Hunter K, McFarlane M, Kubba H. The prevalence of ear, nose and throat disorders in preschool children with Down’s syndrome in Glasgow. Scott Med J 2011;56:98–103.
  • Macchini F, Leva E, Torricelli M, Valadè A. Treating acid reflux disease in patients with Down syndrome: pharmacological and physiological approaches. Clin Exp Gastroenterol 2011;4:19–22.
  • Delacourt C, Hadchouel A, Toelen J, Rayyan M, de Blic J, Deprest J. Long term respiratory outcomes of congenital diaphragmatic hernia, esophageal atresia, and cardiovascular anomalies. Semin Fetal Neonatal Med 2012;17:105–11.
  • Abbas AK, Lichtman AHH, Pillai S. Basic Immunology: Functions and Disorders of the Immune System, 4rd ed. Philadelphia: Saunders Elsevier; 2014.
  • Khocht A, Russell B, Cannon JG, Turner B, Janal M. Phagocytic cell activity and periodontitis in Down syndrome. Oral Dis 2012;18:346–52.
  • Bloemers BL, van Bleek GM, Kimpen JL, Bont L. Distinct abnormalities in the innate immune system of children with Down syndrome. J Pediatr 2010;156:804–9.
  • Nisihara RM, Utiyama SR, Oliveira NP, Messias-Reason IJ. Mannanbinding lectin deficiency increases the risk of recurrent infections in children with Down’s syndrome. Hum Immunol 2010;71:63–6.
  • Bloemers BL, Bont L, de Weger RA, Otto SA, Borghans JA, Tesselaar K. Decreased thymic output accounts for decreased naive T cell numbers in children with Down syndrome. J Immunol 2011;186:4500–7.
  • de Hingh YC, van der Vossen PW, Gemen EF, Mulder AB, Hop WC, Brus F, et al. Intrinsic abnormalities of lymphocyte counts in children with down syndrome. J Pediatr 2005;147:744–7.
  • Kusters MA, Gemen EF, Verstegen RH, Wever PC, DE Vries E. Both normal memory counts and decreased naive cells favor intrinsic defect over early senescence of Down syndrome T lymphocytes. Pediatr Res 2010;67:557–62.
  • Pellegrini FP, Marinoni M, Frangione V, Tedeschi A, Gandini V, Ciglia F, et al. Down syndrome, autoimmunity and T regulatory cells. Clin Exp Immunol 2012;169:238–43.
  • Kusters MA, Verstegen RH, Gemen EF, de Vries E. Intrinsic defect of the immune system in children with Down syndrome: a review. Clin Exp Immunol 2009;156:189–93.
  • Levin S, Schlesinger M, Handzel Z, Hahn T, Altman Y, Czernobilsky B, et al. Thymic deficiency in Down’s syndrome. Pediatrics 1979;63:80– 7.
  • Carsetti R, Valentini D, Marcellini V, Scarsella M, Marasco E, Giustini F, et al. Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome. Eur J Immunol 2015;45:903–14.
  • Joshi AY, Abraham RS, Snyder MR, Boyce TG. Immune evaluation and vaccine responses in Down syndrome: evidence of immunodeficiency? Vaccine 2011;29:5040–6.
  • Valentini D, Marcellini V, Bianchi S, Villani A, Facchini M, Donatelli I, et al. Generation of switched memory B cells in response to vaccination in Down syndrome children and their siblings. Vaccine 2015;33:6689– 96.
  • Barradas C, Charlton J, MendoCa P, Lopes AI, Palha M, Trindade JC. IgG subclasses serum concentrations in a population of children with Down syndrome: comparative study with siblings and general population. Allergol Immunopathol (Madr) 2002;30:57–61.
APA Patıroglu T, CANSEVER M, BEKTAŞ F (2018). Underlying factors of recurrent infections in patients with down syndrome. , 163 - 168. 10.14744/nci.2017.69379
Chicago Patıroglu Türkan,CANSEVER MURAT,BEKTAŞ Fulya Underlying factors of recurrent infections in patients with down syndrome. (2018): 163 - 168. 10.14744/nci.2017.69379
MLA Patıroglu Türkan,CANSEVER MURAT,BEKTAŞ Fulya Underlying factors of recurrent infections in patients with down syndrome. , 2018, ss.163 - 168. 10.14744/nci.2017.69379
AMA Patıroglu T,CANSEVER M,BEKTAŞ F Underlying factors of recurrent infections in patients with down syndrome. . 2018; 163 - 168. 10.14744/nci.2017.69379
Vancouver Patıroglu T,CANSEVER M,BEKTAŞ F Underlying factors of recurrent infections in patients with down syndrome. . 2018; 163 - 168. 10.14744/nci.2017.69379
IEEE Patıroglu T,CANSEVER M,BEKTAŞ F "Underlying factors of recurrent infections in patients with down syndrome." , ss.163 - 168, 2018. 10.14744/nci.2017.69379
ISNAD Patıroglu, Türkan vd. "Underlying factors of recurrent infections in patients with down syndrome". (2018), 163-168. https://doi.org/10.14744/nci.2017.69379
APA Patıroglu T, CANSEVER M, BEKTAŞ F (2018). Underlying factors of recurrent infections in patients with down syndrome. İstanbul Kuzey Klinikleri, 5(2), 163 - 168. 10.14744/nci.2017.69379
Chicago Patıroglu Türkan,CANSEVER MURAT,BEKTAŞ Fulya Underlying factors of recurrent infections in patients with down syndrome. İstanbul Kuzey Klinikleri 5, no.2 (2018): 163 - 168. 10.14744/nci.2017.69379
MLA Patıroglu Türkan,CANSEVER MURAT,BEKTAŞ Fulya Underlying factors of recurrent infections in patients with down syndrome. İstanbul Kuzey Klinikleri, vol.5, no.2, 2018, ss.163 - 168. 10.14744/nci.2017.69379
AMA Patıroglu T,CANSEVER M,BEKTAŞ F Underlying factors of recurrent infections in patients with down syndrome. İstanbul Kuzey Klinikleri. 2018; 5(2): 163 - 168. 10.14744/nci.2017.69379
Vancouver Patıroglu T,CANSEVER M,BEKTAŞ F Underlying factors of recurrent infections in patients with down syndrome. İstanbul Kuzey Klinikleri. 2018; 5(2): 163 - 168. 10.14744/nci.2017.69379
IEEE Patıroglu T,CANSEVER M,BEKTAŞ F "Underlying factors of recurrent infections in patients with down syndrome." İstanbul Kuzey Klinikleri, 5, ss.163 - 168, 2018. 10.14744/nci.2017.69379
ISNAD Patıroglu, Türkan vd. "Underlying factors of recurrent infections in patients with down syndrome". İstanbul Kuzey Klinikleri 5/2 (2018), 163-168. https://doi.org/10.14744/nci.2017.69379