Yıl: 2018 Cilt: 10 Sayı: 3 Sayfa Aralığı: 360 - 368 Metin Dili: İngilizce DOI: 10.18521/ktd.427781

The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study

Öz:
Objective: Rose oil (from Rosa damascene) has several effects which are analgesic,antispasmodic, antioxidant and neuroprotective role. Its antiepileptic effect has notbeen yet studied enough. In the present study, it was aimed to investigate acute effectsof rose oil on the epileptiform activity in penicillin-induced epilepsy model in rats.Methods: Forty-two male Wistar rats weighing 230 to 260 g were divided into sixgroups with seven rats in each group. Control (+Penicillin), RO alone, Diazepam, anddifferent doses of Rose oil including 100, 500 and 1000 mg/kg. Rats were pretreatedwith different doses of RO 30 min prior to penicillin treatment. Electrocorticogramrecordings were taken from each animal for 2 hours after penicillin treatment.Results: Only the dose of 100 mg/kg of rose oil reduced significantly epileptic spikewavefrequency of epileptiform activity. However, comparing in terms of latency andspike-wave amplitude of epileptiform activity, there were no significant differencebetween the groups.Conclusions: In conclusion, acute administration of rose oil reduces spike-wavefrequency of penicillin-induced epileptiform activity in rats. Therefore, these findingsindicate that rose oil has antiepileptic effects.
Anahtar Kelime:

Gül Yağının Sıçanlarda Penisilin İle Tetiklenen Epileptiform Aktivite Üzerine Etkileri: Elektrofizyolojik Bir Çalışma

Öz:
Amaç: Gül yağı analjezik, antispazmodik, antioksidan ve nöroprotektif etkilere sahiptir. Anti-epileptik etki üzerine yapılan çalışmalar ise yetersizdir. Sunulan çalışmada, gül yağının sıçanlarda penisilin ile tetiklenen epilepsi modelinde epileptiform aktivite üzerine akut etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: 230-260 gr ağırlığında kırk iki erkek wistar sıçan her grupta yedi olmak üzere altı gruba ayrıldı. Gruplar kontrol (penisilin), yalnız gül yağı, diazepam ve gül yağının 100, 500 ve 1000 mg/kg olmak üzere farklı dozlarından oluşmaktadır. Sıçanlara penisilin uygulamasından 30 dakika önce gül yağının farklı dozları uygulandı. Penisilin uygulamasından sonra 2 saat boyunca her bir hayvandan elektrokortikogram kayıtları alındı. Bulgular: Gül yağının sadece 100 mg/kg dozu epileptiform aktivitenin epileptik diken-dalga frekansını önemli derecede azalttı. Bununla birlikte epileptiform aktivite latens ve diken-dalga amplitüdü açısından karşılaştırıldığında gruplar arasında anlamlı bir fark yoktu. Sonuç: Gül yağının akut olarak uygulanması sıçanlarda, penisilin ile tetiklenen epileptiform aktivitenin diken-dalga frekansını azaltmaktadır. Böylece bulgularımız gül yağının anti-epileptik etkilere sahip olduğunu göstermektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ANKARALI S, BEYAZÇİÇEK E, KILINÇ E, BEYAZÇİÇEK Ö, ÖZKAN K, ÇETİNKAYA A, CANGÜR Ş, ANKARALI H (2018). The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study. KONURALP TIP DERGİSİ, 10(3), 360 - 368. 10.18521/ktd.427781
Chicago ANKARALI SEYİT,BEYAZÇİÇEK ERSİN,KILINÇ ERKAN,BEYAZÇİÇEK ÖZGE,ÖZKAN Kayhan,ÇETİNKAYA AYHAN,CANGÜR ŞENGÜL,ANKARALI HANDAN The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study. KONURALP TIP DERGİSİ 10, no.3 (2018): 360 - 368. 10.18521/ktd.427781
MLA ANKARALI SEYİT,BEYAZÇİÇEK ERSİN,KILINÇ ERKAN,BEYAZÇİÇEK ÖZGE,ÖZKAN Kayhan,ÇETİNKAYA AYHAN,CANGÜR ŞENGÜL,ANKARALI HANDAN The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study. KONURALP TIP DERGİSİ, vol.10, no.3, 2018, ss.360 - 368. 10.18521/ktd.427781
AMA ANKARALI S,BEYAZÇİÇEK E,KILINÇ E,BEYAZÇİÇEK Ö,ÖZKAN K,ÇETİNKAYA A,CANGÜR Ş,ANKARALI H The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study. KONURALP TIP DERGİSİ. 2018; 10(3): 360 - 368. 10.18521/ktd.427781
Vancouver ANKARALI S,BEYAZÇİÇEK E,KILINÇ E,BEYAZÇİÇEK Ö,ÖZKAN K,ÇETİNKAYA A,CANGÜR Ş,ANKARALI H The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study. KONURALP TIP DERGİSİ. 2018; 10(3): 360 - 368. 10.18521/ktd.427781
IEEE ANKARALI S,BEYAZÇİÇEK E,KILINÇ E,BEYAZÇİÇEK Ö,ÖZKAN K,ÇETİNKAYA A,CANGÜR Ş,ANKARALI H "The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study." KONURALP TIP DERGİSİ, 10, ss.360 - 368, 2018. 10.18521/ktd.427781
ISNAD ANKARALI, SEYİT vd. "The Effect of Rose Oil on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study". KONURALP TIP DERGİSİ 10/3 (2018), 360-368. https://doi.org/10.18521/ktd.427781