Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer
Yıl: 2018 Cilt: 40 Sayı: 3 Sayfa Aralığı: 284 - 290 Metin Dili: İngilizce DOI: 10.7197/223.vi.431429 İndeks Tarihi: 27-02-2020
Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer
Öz: Objective: Gastric cancer is a multifunctional disease. Emotional stress, physiological and neuroendocrine changes incancer patients can lead to the activation of the hypothalamic-pituitary-adrenal axis and the release of hormonedependent hormones such as catecholamine. In particular, it has been reported that catecholamine induction directlyaffects the biological behavior of tumor cells via β2-Adrenergic receptor (β2-AR) mediated signaling. In this study, itwas aimed to investigate polymorphism of β2-AR gene (rs1042717) in gastric cancer patients.Method: Polymorphism in the β2-AR gene (rs1042717) was determined by Real-Time PCR method in 60 gastric cancerpatients and 50 healthy controls. The results were evaluated using logistic regression and Chi-square (χ2) test.Results: The comparison of gastric cancer patients and controls determined a statistically significant relationship foralcoholic drink consumption (p<0,05). There was a statistically significant relationship between β2-AR (rs1042717)polymorphism and stomach cancer (p <0.05). There was a statistically significant relationship between mutant (AA)genotype with wild type (GG) and heterozygous (AG) polymorphic genotypes when evaluated in β2-AR polymorphismgastric cancer patients and control group (χ2: 19,38, p: 0.001). Similarly, there was a statistically significant correlationbetween heterozygous (AG) with wild type (GG) and mutant (AA) polymorphic genotypes in gastric cancer (χ2: 14, 27,p: 0,001).Conclusions: In this study, it was found that the AG genotype is predominant in gastric cancer patients and controls,and that the AA genotype has a protective effect against gastric cancer.
Anahtar Kelime: Konular:
β2-Adrenerjik reseptör (β2-ar) polimorfizmi ile mide kanseri arasındaki ilişkinin incelenmesi
Öz: Amaç: Mide kanseri multi-fonksiyonel bir hastalıktır. Kanser hastalarında duygusal stres, fizyolojik ve nöroendokrin değişiklikler, hipotalamik-pitüiter-adrenal eksenin aktivasyonuna ve katekolamin gibi strese bağlı hormonların serbest bırakılmasına neden olabilmektedir. Özellikle katekolaminin uyarılması ile β2-Adrenerjik reseptör (β2-AR) aracılı sinyal ileti yoluyla tümör hücrelerinin biyolojik davranışlarını doğrudan etkilediği bildirilmiştir. Bu çalışmada, mide kanserli hastalarda β2-AR gen (rs1042717) polimorfizminin araştırılması amaçlanmıştır. Yöntem: β2-AR genindeki polimorfizim (rs1042717) 60 mide kanseri hastası ve 50 sağlıklı kontrol de Real-Time PCR metoduyla belirlendi. Elde edilen sonuçlar, lojistik regresyon ve Khi-kare (χ2) testi kullanılarak değerlendirildi. Bulgular: Mide kanseri hastaları ve kontroller alkol kullanma açısından değerlendirildiğinde, istatistiksel olarak anlamlı bir ilişki belirlendi (p<0,05). β2-AR (rs1042717) polimorfizmi ile mide kanseri arasında istatistiksel olarak anlamlı bir ilişki bulundu (p<0,05). β2-AR (rs1042717) polimorfizmi mide kanseri hastaları ve kontrol grubunda değerlendirildiğinde, mutant (AA) genotipi ile yabanıl tip (GG) ve heterozigot (AG) polimorfik genotipleri arasında istatistiksel olarak anlamlı bir ilişki olduğu görüldü (χ2: 19,38, p: 0,001). Benzer şekilde heterozigot (AG) ile yabanıl tip (GG) ve mutant (AA) polimorfik genotipleri kıyaslandığında ise mide kanserinde istatistiksel olarak anlamlı bir ilişki olduğu saptandı (χ2: 14,27, p:0,001). Sonuç: Bu çalışmada, mide kanseri hastaları ve kontrollerde en çok AG genotipinin hakim olduğu ve ayrıca, AA genotipinin mide kanserine karşı koruyucu bir etkiye sahip olduğu görülmüştür.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Atabey M, TAŞ A, AĞBEKTAŞ T, bostancı m, TOPÇU Ö, SİLİĞ Y (2018). Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. , 284 - 290. 10.7197/223.vi.431429 |
| Chicago | Atabey Mustafa,TAŞ Ayça,AĞBEKTAŞ Tuğba,bostancı meriç emre,TOPÇU Ömer,SİLİĞ Yavuz Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. (2018): 284 - 290. 10.7197/223.vi.431429 |
| MLA | Atabey Mustafa,TAŞ Ayça,AĞBEKTAŞ Tuğba,bostancı meriç emre,TOPÇU Ömer,SİLİĞ Yavuz Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. , 2018, ss.284 - 290. 10.7197/223.vi.431429 |
| AMA | Atabey M,TAŞ A,AĞBEKTAŞ T,bostancı m,TOPÇU Ö,SİLİĞ Y Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. . 2018; 284 - 290. 10.7197/223.vi.431429 |
| Vancouver | Atabey M,TAŞ A,AĞBEKTAŞ T,bostancı m,TOPÇU Ö,SİLİĞ Y Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. . 2018; 284 - 290. 10.7197/223.vi.431429 |
| IEEE | Atabey M,TAŞ A,AĞBEKTAŞ T,bostancı m,TOPÇU Ö,SİLİĞ Y "Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer." , ss.284 - 290, 2018. 10.7197/223.vi.431429 |
| ISNAD | Atabey, Mustafa vd. "Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer". (2018), 284-290. https://doi.org/10.7197/223.vi.431429 |
| APA | Atabey M, TAŞ A, AĞBEKTAŞ T, bostancı m, TOPÇU Ö, SİLİĞ Y (2018). Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. Cumhuriyet Tıp Dergisi (ELEKTRONİK), 40(3), 284 - 290. 10.7197/223.vi.431429 |
| Chicago | Atabey Mustafa,TAŞ Ayça,AĞBEKTAŞ Tuğba,bostancı meriç emre,TOPÇU Ömer,SİLİĞ Yavuz Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. Cumhuriyet Tıp Dergisi (ELEKTRONİK) 40, no.3 (2018): 284 - 290. 10.7197/223.vi.431429 |
| MLA | Atabey Mustafa,TAŞ Ayça,AĞBEKTAŞ Tuğba,bostancı meriç emre,TOPÇU Ömer,SİLİĞ Yavuz Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. Cumhuriyet Tıp Dergisi (ELEKTRONİK), vol.40, no.3, 2018, ss.284 - 290. 10.7197/223.vi.431429 |
| AMA | Atabey M,TAŞ A,AĞBEKTAŞ T,bostancı m,TOPÇU Ö,SİLİĞ Y Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. Cumhuriyet Tıp Dergisi (ELEKTRONİK). 2018; 40(3): 284 - 290. 10.7197/223.vi.431429 |
| Vancouver | Atabey M,TAŞ A,AĞBEKTAŞ T,bostancı m,TOPÇU Ö,SİLİĞ Y Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer. Cumhuriyet Tıp Dergisi (ELEKTRONİK). 2018; 40(3): 284 - 290. 10.7197/223.vi.431429 |
| IEEE | Atabey M,TAŞ A,AĞBEKTAŞ T,bostancı m,TOPÇU Ö,SİLİĞ Y "Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer." Cumhuriyet Tıp Dergisi (ELEKTRONİK), 40, ss.284 - 290, 2018. 10.7197/223.vi.431429 |
| ISNAD | Atabey, Mustafa vd. "Investigation of the relationship between β2- adrenergic receptor (β2-AR) polymorphism and gastric cancer". Cumhuriyet Tıp Dergisi (ELEKTRONİK) 40/3 (2018), 284-290. https://doi.org/10.7197/223.vi.431429 |
