TY  - JOUR
TI  - Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety
AB  - A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNA- andRNA-viruses in mammalian cell cultures. Some of the compounds were found to exhibit moderate antiviral activity. 3-Propyl-2-[((6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)acetyl)hydrazono]-5-methyl-4-thiazolidinone 13, displayedmodest yet consistent activity against three strains of influenza A virus, including the 2009 pandemic virus A/H1N1Virginia/ATCC3/2009 (cytotoxicity >100 μM). Compounds 6 and 11 displayed activity against vesicular stomatitisvirus in HeLa cells (antiviral EC50 values of 9 (cytotoxicity 100 μM) and 2 μM (cytotoxicity 20 μM), respectively). Neitherof the compounds was active against HIV.
AU  - Ulusoy Güzeldemirci, Nuray
AU  - Pehlivan, Erkan
AU  - NAESENS, Lieve
DO  - 10.12991/mpj.2018.61
PY  - 2018
JO  - Marmara Pharmaceutical Journal
VL  - 22
IS  - 2
SN  - 1309-0801
SP  - 237
EP  - 248
DB  - TRDizin
UR  - http://search/yayin/detay/326373
ER  -