TY  - JOUR
TI  - VOLTAMMETRIC DETERMINATION OF ESTRADIOL IN MILK AND PHARMACEUTICALS BASED ON FUMED-SILICA MODIFIED CARBON PASTE ELECTRODE
AB  - In this study, modification of carbon paste electrode (CPE) with a nano-structured substance, fumed silica (FS), wasinvestigated to develop a voltammetric method for the determination of an endocrine disrupting chemical, estradiol (EST). FSprominently increased the voltammetric response of CPE towards EST. The parameters that affect the volmametricperformance of modified CPE were examined to find the optimal conditions. Modified electrode showed a linear responsetowards EST between the concentration values of 0.1 M and 15.0 M EST. Limit of detection value for the method developedwas calculated as 0.023 M. Production reproducibility of the modified electrode was obtained as 3.6 %. The voltammetricbehavior of EST was also examined in the presence of different substances to evaluate their interference effects. The modifiedelectrode successfully discriminated the oxidation potential of EST in the presence of different substances. The determinationof EST was tested in milk and pharmaceutical samples to evaluate the analytical performance of the method. The recoveryanalysis of EST in milk samples showed that the modified electrode can be used safely in these samples. The modified electrodealso achieved the determination of EST in pharmaceutical samples.
AU  - OZCAN, ALI
AU  - TOPÇUOĞULLARI, Duygu
AU  - ATILIR ÖZCAN, Ayça
DO  - 10.18038/aubtda.430622
PY  - 2018
JO  - Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering
VL  - 19
IS  - 4
SN  - 2667-4211
SP  - 963
EP  - 975
DB  - TRDizin
UR  - http://search/yayin/detay/326962
ER  -