TY  - JOUR
TI  - Expression Profiles of TRAIL and Its Receptors in Normal, Hyperplastic, and Malignant Endometrial Tissues: Hints on Endometrial Cancer Biology
AB  - Endometrial cancer is the sixth most common neoplasm in women worldwide, with a rising incidence largely attributed tothe ongoing obesity epidemic. TNF-Related Apoptosis-Inducing Ligand (TRAIL) and TRAIL receptors have been testedfor their predictive, diagnostic, and prognostic values in various cancers, as well as for possible use in combinationtherapies. The roles of TRAIL and its receptors in endometrial tissue biology has not yet been cleared, and the potential ofthese molecules as biomarkers in endometrial cancer is yet to be defined. We investigated the expression profiles of TRAILand its transmembrane receptors during endometrial carcinogenesis to evaluate their potential as prognostic markers.Paraffin-embedded normal endometrium (n=18), endometrial hyperplasia (n=27), and endometrioid endometrialadenocarcinoma tissues (n=100) were analysed for TRAIL and receptor expression profiles via immunohistochemicalstaining. Apoptotic indexes in the corresponding tissues were defined by TUNEL assay.Endometrial carcinoma displayed decreased TRAIL and DR4 expressions compared to the normal endometrium, whileincreased DR5 and decoy receptor (DcR1 and DcR2) expressions were evident. The complex atypical hyperplasia displayedthe most similar expression profiles to the endometrial carcinoma, in accordance with the greatest risk of progression toendometrial carcinoma attributed to this tissue type. TRAIL/TRAIL receptor expression levels did not correlate with theprognostic factors of tumor stage or grade, or depth of myometrial invasion.Overall, distinct profiles of TRAIL and its receptor expressions were evident in progression from normal endometrium tohyperplasia and cancer, which may indicate significance of TRAIL signaling in the course of endometrial carcinomadevelopment.
AU  - ŞANLIOĞLU, Salih
AU  - ŞİMŞEK, Tayup
AU  - ŞANLIOĞLU, AHTER DİLŞAD
AU  - Bisgin, Atil
AU  - ERDOĞAN, Gülgün
AU  - Ozbudak, Irem Hicran
AU  - PEŞTERELİ, Hadice Elif
AU  - AYDIN ACAR, ÇİĞDEM
DO  - 10.5505/ejm.2019.21447
PY  - 2019
JO  - Eastern Journal of Medicine
VL  - 24
IS  - 3
SN  - 1301-0883
SP  - 361
EP  - 370
DB  - TRDizin
UR  - http://search/yayin/detay/327073
ER  -