Introduction: In order to search the success and efficacy of Colon Cancer Screening Program (CCSP), we aimed to evaluate the colonoscopic results of FOBT- positive 300 consecutive individu-als that have been refered to our clinic within the scope of screening program. Method: Demographic features, colonoscopic findings, pathologic results, final diagnosis and treatment results of individuals were examined retrospectively. Results: A hundred and eighty (60%) individuals were women and 120 (40%) individuals were men. The median age of the individuals was 56 (50-70) years. Colorectal carcinoma (CRC) was detected in 12 (4%) patients. İn one patient tubulovillous adenoma with high grade dysplasia (HGD) was detected in broad- based sessile polyp. Laparoscopic surgery in compliance with onco-logic principles was performed in these thirteen patients during the early stage of the disease. Precancerous adenomatous polyps were detected in 120 (40%), and high grade dysplasia (HGD) in 30 (10%) patients. In 42 individuals, benign anorectal diseases (fissure, hemorrhoids) were detected. Twenty-seven (9%) individuals had diverticulosis. According to pathologic results, nine (3%) patients were diagnosed as ulcerative colitis and nineteen (6.3%) patients as nonspecific colitis. Eighty-eight individuals (29.3%) normal colonoscopic findings were reported. Conclusion: Thirteen patients with asymptomatic colon cancer and in one HGD patient with ses-sile polyp received early curative surgery in the early stage opf the disease. In hundred and twenty cases, curative polypectomy was applied to precancerous adenomatous polyps and these all were included in colonoscopic follow- up program. We believe that through widespread use and effective application of CCSP, early diagnosis and treatment rates will increase and mortality and morbidity rates of CRC will be decreased.