Peripheral Nerve Regeneration and Stem Cell Therapies

ÖNGER, MEHMET EMİN; DELİBAŞ, Burcu; HİM, Aydın

Peripheral Nerve Regeneration and Stem Cell Therapies

Aydın HİM, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Biyofizik Anabilim Dalı, Samsun, Türkiye)

Mehmet Emin ÖNGER, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Samsun, Türkiye)

Burcu DELİBAŞ (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Samsun, Türkiye)

Sakarya Tıp Dergisi

7 1

Yıl: 2018 Cilt: 8 Sayı: 2 Sayfa Aralığı: 182 - 192 Metin Dili: İngilizce İndeks Tarihi: 09-03-2020

Peripheral Nerve Regeneration and Stem Cell Therapies

Öz:

In this review, authors aimed to give information about the recent development about the use of stem cell transplantation in damaged nerverepair and highlight the key scientifi c studies. Although peripheral nerves show the potential of regenerating the axon and reinnervetingtheir target tissues, the recovery after intense nerve injury remains relatively poor. Schwann cells play important role in the regenerationsuccess of peripheral nerves. Given that Schwann cells of the denervated peripheral nerve appear to become incapable in regeneration, ithas been considered a reasonable approach to support the distal denervated nerve environment with exogenously derived host cells. Theeffects of various stem cells on peripheral nerve regeneration have been investigated. Skin, bone marrow and adipose derived stem cellswere indicated as the most promising candidates with their potentials of converting into Schwann cells. Beside the application of pluripotentinduced stem cell trials; recent studies have demonstrated that induced expression of growth factors in stem cells has more potential inregeneration. Although the stem cells were considered as effi cient resources and promising agents in nerve regeneration there is nooptimization of these therapies yet for their potential to be realized in a clinical setting.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Periferik Sinir Rejenerasyonu ve Kök Hücre Tedavileri

Öz:

Bu derlemede yazarlar kök hücre hücre transplantasyonunun sinir hasarlarının iyileştirilmesinde kullanımı ile ilgili yakın zamandaki gelişmeler ve bu alandaki başlıca çalışmalar hakkında bilgi vermeyi amaçlamaktadır. Periferik sinirlerin akson rejenerasyonu ve hedef dokularını tekrar innerve etme potansiyeline sahip olmalarına rağmen ağır sinir hasarı durumlarında düzelme sınırlı kalmaktadır. Denervasyona uğramış periferik sinirin Schwann hücrelerinin rejenerasyonda yeteri kadar rol alamayışlarından dolayı denerve olmuş distal sinir dokusu ortamının dış kaynaklı doku hücreleriyle desteklenmesi yaklaşımı gerçekçi görülmüştür. Çeşitli kök hücrelerinin periferik sinir rejenerasyonundaki etkileri çalışılmıştır. Deri, kemik iliği ve yağ doku kökenli kök hücreleri Schwann hücrelerine dönüşme kapasiteleriyle en ümit verici adaylar olarak belirlenmiştir. Pluripotent indüklenmiş kök hücre denemelerine ek olarak, yakın zamanlarda yapılan çalışmalar kök hücrelerinde büyüme faktörlerinin ifadesinin uyarılması da rejenerasyonda önemli potansiyele sahiptir. Kök hücrelerinin etkili kullanılabilecek kaynak olmaları ve sinir rejenerasyonunda ümit verici faktörler olduklarının düşünülmesine rağmen bu hücre tedavi potansiyellerinin klinikte kullanılması için gerekli ideal yöntemler henüz oluşturulamamıştır.

Anahtar Kelime:

Konular: Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	HİM A, ÖNGER M, DELİBAŞ B (2018). Peripheral Nerve Regeneration and Stem Cell Therapies. , 182 - 192.
Chicago	HİM Aydın,ÖNGER MEHMET EMİN,DELİBAŞ Burcu Peripheral Nerve Regeneration and Stem Cell Therapies. (2018): 182 - 192.
MLA	HİM Aydın,ÖNGER MEHMET EMİN,DELİBAŞ Burcu Peripheral Nerve Regeneration and Stem Cell Therapies. , 2018, ss.182 - 192.
AMA	HİM A,ÖNGER M,DELİBAŞ B Peripheral Nerve Regeneration and Stem Cell Therapies. . 2018; 182 - 192.
Vancouver	HİM A,ÖNGER M,DELİBAŞ B Peripheral Nerve Regeneration and Stem Cell Therapies. . 2018; 182 - 192.
IEEE	HİM A,ÖNGER M,DELİBAŞ B "Peripheral Nerve Regeneration and Stem Cell Therapies." , ss.182 - 192, 2018.
ISNAD	HİM, Aydın vd. "Peripheral Nerve Regeneration and Stem Cell Therapies". (2018), 182-192.

APA	HİM A, ÖNGER M, DELİBAŞ B (2018). Peripheral Nerve Regeneration and Stem Cell Therapies. Sakarya Tıp Dergisi, 8(2), 182 - 192.
Chicago	HİM Aydın,ÖNGER MEHMET EMİN,DELİBAŞ Burcu Peripheral Nerve Regeneration and Stem Cell Therapies. Sakarya Tıp Dergisi 8, no.2 (2018): 182 - 192.
MLA	HİM Aydın,ÖNGER MEHMET EMİN,DELİBAŞ Burcu Peripheral Nerve Regeneration and Stem Cell Therapies. Sakarya Tıp Dergisi, vol.8, no.2, 2018, ss.182 - 192.
AMA	HİM A,ÖNGER M,DELİBAŞ B Peripheral Nerve Regeneration and Stem Cell Therapies. Sakarya Tıp Dergisi. 2018; 8(2): 182 - 192.
Vancouver	HİM A,ÖNGER M,DELİBAŞ B Peripheral Nerve Regeneration and Stem Cell Therapies. Sakarya Tıp Dergisi. 2018; 8(2): 182 - 192.
IEEE	HİM A,ÖNGER M,DELİBAŞ B "Peripheral Nerve Regeneration and Stem Cell Therapies." Sakarya Tıp Dergisi, 8, ss.182 - 192, 2018.
ISNAD	HİM, Aydın vd. "Peripheral Nerve Regeneration and Stem Cell Therapies". Sakarya Tıp Dergisi 8/2 (2018), 182-192.