TY  - JOUR
TI  - Effect of various irrigation solutions on cytokine expression of human gingival fibroblast: in vitro study
AB  - Aim: The aim of this study is to investigate the release of IL-1,TNF- α and VEGF following administration of NaOCl, propolisand chitosan solutions on human gingival fibroblasts.Materials and Methods: This study was conducted on humanfibroblast by cell culture and evaluation of the direct effectof various solutions on the cultured cells. The release ofpro-inflammatory interleukin (IL), tumor necrosis factor (TNF)α and vascular endothelial growth factor (VEGF) on fibroblastwas analyzed after administration of irrigation solutions. Logconcentrations of NaOCl, Propolis and Chitosan effects oncells were measured by colorimetric method.Results: IL-1 and TNF-α secretion levels decreased duringpropolis and chitosan applications, which are natural products.It was also found that the propolis increased VEGF secretionmore than the other materials.Conclusions: The results of this study suggest that propolisand chitosan may contribute to the recovery of periapical tissuesvia anti-inflammatory cytokines level secreted during theinflammatory process. It is important to search for the biologicaleffect of the materials in contact with the direct or indirectcause of the surrounding tissues during the endodontic treatment.
AU  - UĞUR AYDIN, ZELİHA
AU  - alpay, merve
AU  - HEPOKUR, Ceylan
AU  - AKPINAR, Kerem Engin
AU  - altunbaş, demet
DO  - 10.5505/yeditepe.2019.96268
PY  - 2019
JO  - 7tepe Klinik
VL  - 15
IS  - 2
SN  - 2458-9586
SP  - 198
EP  - 203
DB  - TRDizin
UR  - http://search/yayin/detay/329756
ER  -