Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center

TANACAN, Efsun; BEKSAÇ, Mehmet Sinan; TANAÇAN, Atakan; FADILOĞLU, Erdem; ÜNAL, Canan

doi:10.21613/GORM.2018.850

Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center

Efsun TANACAN, (adres belirtilmemiş)

Atakan TANAÇAN, (adres belirtilmemiş)

Erdem FADILOĞLU, (adres belirtilmemiş)

Canan ÜNAL, (adres belirtilmemiş)

Mehmet Sinan BEKSAÇ (adres belirtilmemiş)

GORM:Gynecology Obstetrics & Reproductive Medicine

0 0

Yıl: 2019 Cilt: 25 Sayı: 3 Sayfa Aralığı: 128 - 132 Metin Dili: İngilizce DOI: 10.21613/GORM.2018.850 İndeks Tarihi: 29-03-2020

Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center

Öz:

OBJECTIVE: To evaluate the impact of psoriasis on pregnancy outcomes.STUDY DESIGN: Data of pregnant women with chronic plaque psoriasis who were followed up at Ha -cet tepe University Hospital between January 1, 2010 and December 31, 2017 were evaluated. Pregnantwomen with singleton pregnancies who had chronic plaque psoriasis were included in the study.Patients were divided into two groups based on the clinical course of psoriasis: group 1 (improvement/disease-stable), and group 2 (deterioration). Median maternal age, gravida, parity, gestationalweek at birth, birthweight, 5th minute Apgar score together with the rates of cesarean section, neonatalintensive care unit admission and pregnancy complications (spontaneous abortion, preterm delivery,fetal growth restriction and preeclampsia) were compared between the groups.RESULTS: There were 29 (61.7%) patients in group 1 and 18 (38.3%) patients in group 2. Mean values for maternal age, gravida and parity were comparable between the groups (p values were 0.32, 0.09and 0.17, respectively). Median values for gestational week at birth (39.2 vs 36.1, p=0.002), birthweight(3200 vs 2310, p=0.002) and 5th minute Apgar score (9 vs 7, p<0.001) were statistically significantlylower in group 2. Cesarean section (33.3% vs 71.4%, p=0.02), neonatal intensive care unit admission(11.1% vs 64.3%, p<0.001) and pregnancy complication rates (p=0.003) were statistically significantlyhigher in group 2. Frequencies of spontaneous abortion, preterm delivery, fetal growth restriction andpreeclampsia were 6.9%, 10.3%, 3.4% and 3.4% in group 1, and 22.2%, 27.8%, 16.7% and 16.7% ingroup 2, respectively.CONCLUSION: Deterioration of psoriasis in pregnancy was associated with adverse obstetric outcome.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Bobotsis R, Gulliver WP, Monaghan K, Lynde C, Fleming P. Psoriasis and adverse pregnancy outcomes: A systematic review of observational studies. Br J Dermatol. 2016;175(3):464-72.
2. Lima XT, Janakiraman V, Hughes MD, Kimball AB. The impact of psoriasis on pregnancy outcomes. J Invest Dermatol. 2012;132(1):85-91.
3. Harden JL, Krueger JG, Bowcock AM. The immunogenetics of psoriasis: a comprehensive review. J Autoimmun. 2015;64:66-73.
4. Krueger J, Bowcock A. Psoriasis pathophysiology: current concepts of pathogenesis. Ann Rheum Dis. 2005;64 (suppl 2):ii30-ii6.
5. Huerta C, Rivero E, Rodríguez LAG. Incidence and risk factors for psoriasis in the general population. Arch Dermatol. 2007;143(12):1559-65.
6. Pearce DJ, Morrison AE, Higgins KB, Crane MM, Balkrishnan R, Fleischer AB, Jr., et al. The comorbid state of psoriasis patients in a university dermatology practice. J Dermatolog Treat. 2005;16(5-6):319-23.
7. Brauchli YB, Jick SS, Miret M, Meier CR. Psoriasis and risk of incident cancer: an inception cohort study with a nested case-control analysis. J Invest Dermatol. 2009;129(11):2604-12.
8. Wu JJ, Nguyen TU, Poon KY, Herrinton LJ. The association of psoriasis with autoimmune diseases. J Am Acad Dermatol. 2012;67(5):924-30.
9. Hamilton MP, Ntais D, Griffiths CE, Davies LM; Identification and Management of Psoriasis-Associated ComorbidiTy (IMPACT) Team. Psoriasis treatment and management–a systematic review of full economic evaluations. Br J Dermatol. 2015;172(3):574-83.
10. Murase JE, Chan KK, Garite TJ, Cooper DM, Weinstein GD. Hormonal effect on psoriasis in pregnancy and post partum. Arch Dermatol. 2005;141(5):601-6.
11. Danesh MJ, Murase JE. The new US Food and Drug Administration pregnancy and lactation labeling rules: Their impact on clinical practice. J Am Acad Dermatol. 2015;73(2):310-1.
12. Bernhard JD. Auspitz sign is not sensitive or specific for psoriasis. J Am Acad Dermatol. 1990;22(6 Pt 1):1079-81.
13. Mattei PL, Corey KC, Kimball AB. Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): the correlation between disease severity and psychological burden in patients treated with biological therapies. J Eur Acad Dermatol Venereol. 2014; 28(3): 333-7.
14. Regan L, Rai R. Epidemiology and the medical causes of miscarriage. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14(5):839-54.
15. Sabour S. Prediction of preterm delivery using levels of VEGF and leptin in amniotic fluid from the second trimester: prediction rules. Arch Gynecol Obstet. 2015;291(4):719.
16. Benton SJ, McCowan LM, Heazell AE, Grynspan D, Hutcheon JA, Senger C, et al. Placental growth factor as a marker of fetal growth restriction caused by placental dysfunction. Placenta. 2016;42:1-8.
17. Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennström M, et al. Predictive value of the sFlt-1: PlGF ratio in women with suspected preeclampsia. N Engl J Med. 2016;374(1):13-22.
18. Beksaç K, Örgül G, Çağan M, Karaağaoğlu E, Arslan S, Beksaç MS. Retrospective evaluation of pregnant women with celiac disease. J Turk Ger Gynecol Assoc. 2017; 18(1):56-9.
19. Beksac K, Orgul G, Can GS, Oktem A, Kav T, Beksac MS. Management of inflammatory bowel disease and pregnancy using prophylactic low dose low molecular weight heparin and corticosteroids. J Clin Diagn Res. 2017;11(11)::QR01-QR03.
20. Orgul G, Aktoz F, Beksac MS. Behcet’s disease and pregnancy: what to expect? J Obstet Gynaecol. 2018;38(2): 185-8.
21. Orgul G, Ozkan EU, Celik HT, Beksac MS. Autoimmune hepatitis and pregnancy: report of two cases with different maternal outcomes. Clin Exp Hepatol. 2017;3(4):212-4.
22. De Simone C, Caldarola G, Corbeddu M, Moro F, Tropea A, Moretta G, et al. A possible role of polycystic ovary syndrome for pregnancy complications in women with psoriasis. Drug Dev Res. 2014;75 Suppl 1:S64-6.
23. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T cell paradigm in pregnancy. Am J Reprod Immunol. 2010;63(6):601-10.
24. Bandoli G, Johnson DL, Jones KL, Lopez Jiminez J, Salas E, Mirrasoul N, et al. Potentially modifiable risk factors for adverse pregnancy outcomes in women with psoriasis. Am J Reprod Immunol. 2010;163(2):334-9.
25. Boyd AS, Morris LF, Phillips CM, Menter MA. Psoriasis and pregnancy: hormone and immune system interaction. Int J Dermatol. 1996;35(3):169-72.
26. Briggs GG. Drugs In Pregnancy And Lactation, For Pda: A Reference Guide To Fetal And Neonatal Risk: Lippincott Williams & Wilkins; 2005.
27. Mahadevan U, Wolf DC, Dubinsky M, Cortot A, Lee SD, Siegel CA, et al. Placental transfer of anti-tumor necrosis factor agents in pregnant patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2013;11(3): 286-92.
28. Cheent K, Nolan J, Shariq S, Kiho L, Pal A, Arnold J. Case report: fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn's disease. J Crohns Colitis. 2010;4(5):603-5.
29. Sorokin Y, Romero R, Mele L, Wapner RJ, Iams JD, Dudley DJ, et al. Maternal serum interleukin-6, C-reactive protein, and matrix metalloproteinase-9 concentrations as risk factors for preterm birth <32 weeks and adverse neonatal outcomes. Am J Perinatol. 2010;27(8):631-40.
30. Amarilyo G, Oren A, Mimouni F, Ochshorn Y, Deutsch V, Mandel D. Increased cord serum inflammatory markers in small-for-gestational-age neonates. J Perinatol. 2011;31 (1):30-2.

APA	TANACAN E, TANAÇAN A, FADILOĞLU E, ÜNAL C, BEKSAÇ M (2019). Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. , 128 - 132. 10.21613/GORM.2018.850
Chicago	TANACAN Efsun,TANAÇAN Atakan,FADILOĞLU Erdem,ÜNAL Canan,BEKSAÇ Mehmet Sinan Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. (2019): 128 - 132. 10.21613/GORM.2018.850
MLA	TANACAN Efsun,TANAÇAN Atakan,FADILOĞLU Erdem,ÜNAL Canan,BEKSAÇ Mehmet Sinan Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. , 2019, ss.128 - 132. 10.21613/GORM.2018.850
AMA	TANACAN E,TANAÇAN A,FADILOĞLU E,ÜNAL C,BEKSAÇ M Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. . 2019; 128 - 132. 10.21613/GORM.2018.850
Vancouver	TANACAN E,TANAÇAN A,FADILOĞLU E,ÜNAL C,BEKSAÇ M Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. . 2019; 128 - 132. 10.21613/GORM.2018.850
IEEE	TANACAN E,TANAÇAN A,FADILOĞLU E,ÜNAL C,BEKSAÇ M "Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center." , ss.128 - 132, 2019. 10.21613/GORM.2018.850
ISNAD	TANACAN, Efsun vd. "Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center". (2019), 128-132. https://doi.org/10.21613/GORM.2018.850

APA	TANACAN E, TANAÇAN A, FADILOĞLU E, ÜNAL C, BEKSAÇ M (2019). Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. GORM:Gynecology Obstetrics & Reproductive Medicine, 25(3), 128 - 132. 10.21613/GORM.2018.850
Chicago	TANACAN Efsun,TANAÇAN Atakan,FADILOĞLU Erdem,ÜNAL Canan,BEKSAÇ Mehmet Sinan Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. GORM:Gynecology Obstetrics & Reproductive Medicine 25, no.3 (2019): 128 - 132. 10.21613/GORM.2018.850
MLA	TANACAN Efsun,TANAÇAN Atakan,FADILOĞLU Erdem,ÜNAL Canan,BEKSAÇ Mehmet Sinan Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.25, no.3, 2019, ss.128 - 132. 10.21613/GORM.2018.850
AMA	TANACAN E,TANAÇAN A,FADILOĞLU E,ÜNAL C,BEKSAÇ M Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. GORM:Gynecology Obstetrics & Reproductive Medicine. 2019; 25(3): 128 - 132. 10.21613/GORM.2018.850
Vancouver	TANACAN E,TANAÇAN A,FADILOĞLU E,ÜNAL C,BEKSAÇ M Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center. GORM:Gynecology Obstetrics & Reproductive Medicine. 2019; 25(3): 128 - 132. 10.21613/GORM.2018.850
IEEE	TANACAN E,TANAÇAN A,FADILOĞLU E,ÜNAL C,BEKSAÇ M "Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center." GORM:Gynecology Obstetrics & Reproductive Medicine, 25, ss.128 - 132, 2019. 10.21613/GORM.2018.850
ISNAD	TANACAN, Efsun vd. "Psoriasis and Pregnancy: Retrospective Evaluation of 47 Pregnancies in a Tertiary Center". GORM:Gynecology Obstetrics & Reproductive Medicine 25/3 (2019), 128-132. https://doi.org/10.21613/GORM.2018.850