TY  - JOUR
TI  - Changing Trends in Radiotherapy for Glioblastoma Multiforme and Effects on Normal Tissue Doses
AB  - Introduction: The aim of the study is to reveal the changingtrends in radiotherapy (RT) for glioblastoma multiforme (GBM)from past to present and to show the changes in organs at risk(OARs) doses.Methods: We re-planned 10 GBM patients who werepreviously irradiated. Rigid fusion was performed throughpre- and postoperative magnetic resonance imaging (MRI) andsimulation computed tomography, and 9 separate volumes werecreated. While volumes varied from whole brain RT (WBRT) topostoperative two-phase irradiation, RT application ranged from2-dimensional Co-60 treatment to 3-dimensional volumetricmodulated arc therapy (VMAT). OARs were contoured, and doseswere noted. A 3 dimensional-conformal RT (3D-CRT) plan of thevolume created by preoperative MRI was compared to 3D-CRTand VMAT plans generated by postoperative MRI. Statisticalanalysis was performed using Paired sample t-test.Results: During the time of WBRT, normal brain tissue wasreceiving 45-60 Gy. Through VMAT, the median brain-planningtarget volume (PTV) Dmean decreased to 35 Gy. According to bothPTV-Radiation Therapy Oncology Group (RTOG)preop and PTVRTOGpreop3D-CRT plannings, there was no difference in all OARsdoses between plans, including brain-PTV initial volume Dmeanand brain-PTV boost Dmean doses. Significantly lower OARs doseswere obtained from 3D-CRT plans based on both PTV-RTOGpreopand PTV-RTOGpostop volumes with the VMAT planning.Conclusion: With changing trends in RT for GBM, there hasbeen a significant decrease in treatment volumes and normaltissue doses. According to the postoperative volume definition ofRTOG, lower normal tissue doses are obtained from VMAT plans,compared to the conformal treatment plans.
AU  - KOKSAL, CANAN
AU  - AKBAŞ, Uğur
AU  - ALTUN, MUSA
AU  - İBİŞ, Kamuran
DO  - 10.4274/imj.galenos.2018.79926
PY  - 2019
JO  - İstanbul Medical Journal
VL  - 20
IS  - 1
SN  - 2619-9793
SP  - 49
EP  - 53
DB  - TRDizin
UR  - http://search/yayin/detay/332334
ER  -