Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey
Yıl: 2019 Cilt: 46 Sayı: 4 Sayfa Aralığı: 857 - 865 Metin Dili: İngilizce DOI: 10.5798/dicletip.579312 İndeks Tarihi: 20-04-2020
Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey
Öz: Objective: Cervical cancer (CC) is the 4th most common cause of cancer-related deaths in women all over the world.The most important etiologic cause is HPV, and this allows tumor to have high chance of curing with early diagnosisby screening programs. However, information about long-term survival data of CC is limited in our country. In ourstudy; we wanted to reveal the survival times of our patients with CC and the factors that predict these times.Methods: Seventy-three patients with CC, followed between 2000 and 2017 were analyzed retrospectively.Associations between clinical and histopathological parameters with overall survival (OS) and progression-freesurvival (PFS) were analyzed using Kaplan- Meier curves and compared by the log-rank test. Univariate andmultivariate analysis were used to assess their prognostic values for PFS and OS.Results: The median age of the patients was 56 years. The most common histological subtype was squamous cellcarcinoma (79.5%) followed by adenocarcinoma (16.4%).According to FIGO staging system, 31 (43.8%) of thepatients were diagnosed as stage 1-2 and 42 (56.2%) were as stage 3-4.The median PFS and OS are 44 months and 78months. The 5-year survival rate is 37.5% (12%-75%). Although there was no difference in length of life betweenhistological subtypes, both PFS and OS were longer in patients with good ECOG performance score (0-1), early FIGOstage (1-2), tumor size <4 cm, and without parametrial and lymph node involvement. Multivariate analysis showedthat ECOG performance score, parametrial involvement and lymph node involvement were independent prognosticfactors for PFS and OS.Conclusion: The stage at time of diagnosis of CC patients in our region is more advanced and their 5-year survivalrates are below the world average, so our women need to be better informed about this subject.
Anahtar Kelime: Konular:
Servikal Kanser Hastalarinin Uzun Dönem Sonuçlari: Doğu Anadolu Tek Merkez Deneyimi
Öz: Amaç: Servikal kanser (SK) tüm dünyada kadınlarda kansere bağlı ölümlerin en sık 4. Sebebi iken ülkemizde 12. Sebebidir. En önemli etyolojik neden HPV olması nedeniyle tarama programları ile erken tanı ile kür olma şansı yüksek olan tümörlerdendir. Ancak ülkemizde SK’lerin uzun dönem yaşam verileri ile ilgili bilgiler kısıtlıdır. Bizde çalışmamızda öncelikli olarak SK tanılı hastalarımızın yaşam sürelerini ve bu süreleri predikte eden faktörleri ortaya koymak istedik. Yöntemler: Erzurum Atatürk Üniversitesi Tıp Fakültesi Tıbbi Onkoloji Anabilim Dalı'nda 2007-2017 yılları arasında SK nedeniyle takip edilen 73 hasta çalışmaya retrospektif olarakdahil edildi. Genel sağkalım (OS) ve progresyonsuz sağkalım (PFS) ile klinikopatolojik parametreler arasındaki ilişkiler Kaplan-Meier eğrileri kullanılarak analiz edildi ve log-rank testi ile karşılaştırıldı. Tek ve çok değişkenli analiz kriterlerin PFS ve OS için prognostik önemlerini tespit etmek için kullanılmıştır. Bulgular: Hastaların median yaşı 56’dır. En sık görülen histolojik alttip skuamoz hücreli karsinom (%79,5) ardından adenokarsinom (%16,4) gelmektedir. FIGO evreleme sistemine göre hastaların 31’i (%43,8) evre 1-2, 42’si (%56,2) evre 3-4 olarak tanı almıştır. Median PFS ve OS 44 ay ve 78 aydır. 5 yıllık yaşam oranı %37,5 (%12-%75) dur. Histolojik alttiplerin yaşam süreleri arasında fark olmamakla beraber ECOG performans skoru iyi (0-1) olanların, erken FIGO evresi (1-2) olanların, tumor boyutu <4 cm olanların, parametrial ve lenf nodu tutulumu olmayanların hem PFS hem de OS leri daha uzundur. Multivariate analizler sonucunda ECOG performans skoru, parametrial tutulum ve lenf nodu tutulumu PFS ve OS için bağımsız prognostik faktör olduğu tespit edilmiştir. Sonuç: Bölgemizdeki SK’li hastaların tanı anında evreleri daha ileri ve 5 yıllık yaşam oranları dünya ortalamalarının altındandır bu sebeple kadınlarımızın bu konuda daha iyi bilinçlendirilmeleri gerekmektedir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | MİRİLİ c, YILMAZ A, BİLİCİ M, Tekin S (2019). Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. , 857 - 865. 10.5798/dicletip.579312 |
| Chicago | MİRİLİ cem,YILMAZ ALİ,BİLİCİ Mehmet,Tekin Salim Basol Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. (2019): 857 - 865. 10.5798/dicletip.579312 |
| MLA | MİRİLİ cem,YILMAZ ALİ,BİLİCİ Mehmet,Tekin Salim Basol Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. , 2019, ss.857 - 865. 10.5798/dicletip.579312 |
| AMA | MİRİLİ c,YILMAZ A,BİLİCİ M,Tekin S Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. . 2019; 857 - 865. 10.5798/dicletip.579312 |
| Vancouver | MİRİLİ c,YILMAZ A,BİLİCİ M,Tekin S Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. . 2019; 857 - 865. 10.5798/dicletip.579312 |
| IEEE | MİRİLİ c,YILMAZ A,BİLİCİ M,Tekin S "Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey." , ss.857 - 865, 2019. 10.5798/dicletip.579312 |
| ISNAD | MİRİLİ, cem vd. "Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey". (2019), 857-865. https://doi.org/10.5798/dicletip.579312 |
| APA | MİRİLİ c, YILMAZ A, BİLİCİ M, Tekin S (2019). Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. Dicle Tıp Dergisi, 46(4), 857 - 865. 10.5798/dicletip.579312 |
| Chicago | MİRİLİ cem,YILMAZ ALİ,BİLİCİ Mehmet,Tekin Salim Basol Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. Dicle Tıp Dergisi 46, no.4 (2019): 857 - 865. 10.5798/dicletip.579312 |
| MLA | MİRİLİ cem,YILMAZ ALİ,BİLİCİ Mehmet,Tekin Salim Basol Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. Dicle Tıp Dergisi, vol.46, no.4, 2019, ss.857 - 865. 10.5798/dicletip.579312 |
| AMA | MİRİLİ c,YILMAZ A,BİLİCİ M,Tekin S Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. Dicle Tıp Dergisi. 2019; 46(4): 857 - 865. 10.5798/dicletip.579312 |
| Vancouver | MİRİLİ c,YILMAZ A,BİLİCİ M,Tekin S Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey. Dicle Tıp Dergisi. 2019; 46(4): 857 - 865. 10.5798/dicletip.579312 |
| IEEE | MİRİLİ c,YILMAZ A,BİLİCİ M,Tekin S "Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey." Dicle Tıp Dergisi, 46, ss.857 - 865, 2019. 10.5798/dicletip.579312 |
| ISNAD | MİRİLİ, cem vd. "Long-Term Follow-Up Outcomes of Cervical Cancer Patients: A Single Center Experience from the East Anatolian Region of Turkey". Dicle Tıp Dergisi 46/4 (2019), 857-865. https://doi.org/10.5798/dicletip.579312 |
