Yıl: 2019 Cilt: 3 Sayı: 1 Sayfa Aralığı: 49 - 58 Metin Dili: İngilizce DOI: 10.14744/ejmo.2018.0089 İndeks Tarihi: 22-04-2020

Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?

Öz:
Objectives: There are limited data regarding the effect of comorbidities in the intensive care unit (ICU) and 12-monthmortality rates of patients with acute respiratory failure (ARF) who are admitted to the ICU. The present investigationwas designed to determine the effect of comorbidities and identify long-term mortality predictors in this patient group.Methods: A retrospective observational cohort study was performed in a 22-bed, tertiary ICU in a teaching and research hospital. All patients who were admitted to the ICU during 2012 were included in the study. Demographics,comorbidities, ICU data at the time of admission, and the last control were recorded. ICU mortality and 12-month mortality after ICU discharge were analyzed by Cox regression and Kaplan–Meier survival analysis.Results: During the study period, 1022 patients (362 females) were admitted to the ICU, and the ICU mortality was20.8%. Older age, non-invasive mechanical ventilation failure, more invasive mechanical ventilation days, tachycardia,Acute Physiological and Chronic Health Evaluation (APACHE II) score at the time of admission, low albumin, and theratio of partial arterial oxygen pressure to inspired fractionated oxygen were associated with increased mortality. Interestingly, the presence of chronic obstructive pulmonary disease (COPD) was associated with decreased mortality.The 12-month mortality rate of the 809 patients who were discharged from the ICU was 51.9% (n = 420). Half of thesepatients died within the first 2 months after discharge. Cancer, low albumin, and higher APACHE II score at the time ofdischarge were identified as mortality risk factors.Conclusion: Patients with ARF who are admitted to the ICU have a higher rate of mortality, and only half survive >1year after discharge. COPD is a comorbid disease associated with an increased likelihood of long-term survival, whereasmalignancy is associated with poor prognosis after ICU discharge.
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  • 1.Vasilyev S, Schaap RN, Mortensen JD. Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units. An international, multicenter, prospective survey. Chest 1995;107:1083–8.
  • 2. Luhr OR, Antonsen K, Karlsson M, Aardal S, Thorsteinsson A, Frostell CG, et al. Incidence and mortality after acute respiratory failure and acute respiratory distress syndrome in sweden, denmark, and iceland. The ARF study group. Am J Respir Crit Care Med 1999;159:1849–61.
  • 3. Belenguer-Muncharaz A, Albert-Rodrigo L, Ferrandiz-Sellés A, Cebrián-Graullera G. Ten-year evolution of mechanical ventilation in acute respiratory failure in the hematogical patient admitted to the intensive care unit. Med Intensiva 2013;37:452–60.
  • 4. Duarte AG, Justino E, Bigler T, Grady J. Outcomes of morbidly obese patients requiring mechanical ventilation for acute respiratory failure. Crit Care Med 2007;35:732–7.
  • 5. Azoulay E, Soares M, Darmon M, Benoit D, Pastores S, Afessa B, et al. Intensive care of the cancer patient: Recent achievements and remaining challenges. Ann Intensive Care 2011;1:5.
  • 6. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevent of Chronic Obstructive Pulmonary Disease, Updated 2014. Available at: http://www.goldcopd.org. Accessed Feb 05, 2104.
  • 7. Funk GC, Bauer P, Burghuber OC, Fazekas A, Hartl S, Hochrieser H, et al. Prevalence and prognosis of COPD in critically ill pa- tients between 1998 and 2008. Eur Respir J 2013;41:792–9.
  • 8. M PN. World medical association publishes the revised declaration of helsinki. Natl Med J India 2014;27:56.
  • 9. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: A severity of disease classification system. Crit Care Med 1985;13:818–29.
  • 10. Nava S, Hill N. Non-invasive ventilation in acute respiratory failure. Lancet 2009;374:250–9.
  • 11. Ambrosino N, Vagheggini G. Noninvasive positive pressure ventilation in the acute care setting: Where are we? Eur Respir J 2008;31:874–86.
  • 12. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Intensive Care Med 2003;29:530–8.
  • 13. Spoelstra-de Man AM, Girbes AR. Comment on surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008 by Dellinger et al. Intensive Care Med 2008;34:1160–2.
  • 14. Ambrosino N, Vagheggini G. Non-invasive ventilation in exacerbations of COPD. Int J Chron Obstruct Pulmon Dis 2007;2:471–6.
  • 15. Sessler CN, Gosnell MS, Grap MJ, Brophy GM, O'Neal PV, Keane KA, et al. The richmond agitation-sedation scale: Validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002;166:1338–44.
  • 16. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C, et al. Weaning from mechanical ventilation. Eur Respir J 2007;29:1033–56.
  • 17. Ai-Ping C, Lee KH, Lim TK. In-hospital and 5-year mortality of patients treated in the ICU for acute exacerbation of COPD: A retrospective study. Chest 2005;128:518–24.
  • 18. Knaus WA. Prognosis with mechanical ventilation: The influence of disease, severity of disease, age, and chronic health status on survival from an acute illness. Am Rev Respir Dis 1989;140:S8–13.
  • 19. Williams TA, Dobb GJ, Finn JC, Knuiman MW, Geelhoed E, Lee KY, et al. Determinants of long-term survival after intensive care. Crit Care Med 2008;36:1523–30.
  • 20. Alaithan AM, Memon JI, Rehmani RS, Qureshi AA, Salam A. Chronic obstructive pulmonary disease: Hospital and intensive care unit outcomes in the kingdom of saudi arabia. Int J Chron Obstruct Pulmon Dis 2012;7:819–23.
  • 21. Raurich JM, Pérez J, Ibáñez J, Roig S, Batle S. In-hospital and 2-year survival of patients treated with mechanical ventilation for acute exacerbation of COPD. Arch Bronconeumol 2004;40:295–300.
  • 22. Celikel T, Sungur M, Ceyhan B, Karakurt S. Comparison of noninvasive positive pressure ventilation with standard medical therapy in hypercapnic acute respiratory failure. Chest 1998;114:1636–42.
  • 23. Plant PK, Owen JL, Elliott MW. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: A multicentre randomised controlled trial. Lancet 2000;355:1931–5.
  • 24. Garcia-Aymerich J, Serra Pons I, Mannino DM, Maas AK, Miller DP, Davis KJ, et al. Lung function impairment, COPD hospitalisations and subsequent mortality. Thorax 2011;66:585–90.
  • 25. Connors AF Jr. Dawson NV, Thomas C, Harrell FE Jr. Desbiens N, Fulkerson WJ, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to understand prognoses and preferences for outcomes and risks of treatments) Am J Respir Crit Care Med 1996;154:959–67.
  • 26. Eriksen N, Hansen EF, Munch EP, Rasmussen FV, Vestbo J. Chronic obstructive pulmonary disease. Admission, course and prognosis. Ugeskr Laeger 2003;165:3499–502.
  • 27. Siegelaar SE, Hoekstra JB, DeVries JH. Special considerations for the diabetic patient in the ICU; targets for treatment and risks of hypoglycaemia. Best Pract Res Clin Endocrinol Metab 2011;25:825–34.
  • 28. Egi M, Bellomo R, Stachowski E, French CJ, Hart GK, Hegarty C, et al. Blood glucose concentration and outcome of critical illness: The impact of diabetes. Crit Care Med 2008;36:2249–55.
  • 29. Falciglia M, Freyberg RW, Almenoff PL, D'Alessio DA, Render ML. Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med 2009;37:3001– 9.
  • 30. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS, et al. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med 2010;38:16–24.
  • 31. Rady MY, Johnson DJ, Patel BM, Larson JS, Helmers RA. Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus. Mayo Clin Proc 2005;80:1558–67.
  • 32. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006;105:244–52.
  • 33. Krinsley JS. Glycemic variability and mortality in critically ill patients: The impact of diabetes. J Diabetes Sci Technol 2009;3:1292–301.
  • 34. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008;34:17–60.
  • 35. Jacob S, Nitschmann S. Intensive or conventional glucose control in critically ill patients: NICE-SUGAR (The normoglycemia in intensive care evaluation-survival using glucose algorithm regulation study). Internist (Berl) 2010;51:670, 672–3.
  • 36. Sechterberger MK, Bosman RJ, Oudemans-van Straaten HM, Siegelaar SE, Hermanides J, Hoekstra JB, et al. The effect of diabetes mellitus on the association between measures of glycaemic control and ICU mortality: A retrospective cohort study. Crit Care 2013;17:R52.
  • 37. Boussat S, El'rini T, Dubiez A, Depierre A, Barale F, Capellier G, et al. Predictive factors of death in primary lung cancer patients on admission to the intensive care unit. Intensive Care Med 2000;26:1811–6.
  • 38. Lin YC, Tsai YH, Huang CC, Hsu KH, Wang SW, Tsao TC, et al. Outcome of lung cancer patients with acute respiratory failure requiring mechanical ventilation. Respir Med 2004;98:43– 51.
  • 39. Reichner CA, Thompson JA, O'Brien S, Kuru T, Anderson ED. Outcome and code status of lung cancer patients admitted to the medical ICU. Chest 2006;130:719–23.
  • 40. Soares M, Darmon M, Salluh JIF, Ferreira CG, Thiéry G, Schlemmer B, et al. Prognosis of lung cancer patients with life-threatening complications. Chest 2007;131:840–6.
  • 41. Adam AK, Soubani AO. Outcome and prognostic factors of lung cancer patients admitted to the medical intensive care unit. Eur Respir J 2008;31:47–53.
  • 42. Roques S, Parrot A, Lavole A, Ancel PY, Gounant V, Djibre M, et al. Six-month prognosis of patients with lung cancer admitted to the intensive care unit. Intensive Care Med 2009;35:2044– 50.
  • 43. Toffart AC, Minet C, Raynard B, Schwebel C, Hamidfar-Roy R, Diab S, et al. Use of intensive care in patients with nonresectable lung cancer. Chest 2011;139:101–8.
  • 44. Azoulay E, Thiéry G, Chevret S, Moreau D, Darmon M, Bergeron A, et al. The prognosis of acute respiratory failure in critically ill cancer patients. Medicine (Baltimore) 2004;83:360–70.
APA BERK TAKIR H, KARAKURT Z, ÇİFTASLAN GÖKŞENOĞLU N, Salturk C, YAZICIOĞLU MOÇİN Ö, ÖZTİN A, ADIGÜZEL N, GÜNGÖR G (2019). Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. , 49 - 58. 10.14744/ejmo.2018.0089
Chicago BERK TAKIR HURİYE,KARAKURT ZÜHAL,ÇİFTASLAN GÖKŞENOĞLU Nezihe,Salturk Cuneyt,YAZICIOĞLU MOÇİN Özlem,ÖZTİN Ayşem Aşkım,ADIGÜZEL NALAN,GÜNGÖR Gökay Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. (2019): 49 - 58. 10.14744/ejmo.2018.0089
MLA BERK TAKIR HURİYE,KARAKURT ZÜHAL,ÇİFTASLAN GÖKŞENOĞLU Nezihe,Salturk Cuneyt,YAZICIOĞLU MOÇİN Özlem,ÖZTİN Ayşem Aşkım,ADIGÜZEL NALAN,GÜNGÖR Gökay Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. , 2019, ss.49 - 58. 10.14744/ejmo.2018.0089
AMA BERK TAKIR H,KARAKURT Z,ÇİFTASLAN GÖKŞENOĞLU N,Salturk C,YAZICIOĞLU MOÇİN Ö,ÖZTİN A,ADIGÜZEL N,GÜNGÖR G Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. . 2019; 49 - 58. 10.14744/ejmo.2018.0089
Vancouver BERK TAKIR H,KARAKURT Z,ÇİFTASLAN GÖKŞENOĞLU N,Salturk C,YAZICIOĞLU MOÇİN Ö,ÖZTİN A,ADIGÜZEL N,GÜNGÖR G Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. . 2019; 49 - 58. 10.14744/ejmo.2018.0089
IEEE BERK TAKIR H,KARAKURT Z,ÇİFTASLAN GÖKŞENOĞLU N,Salturk C,YAZICIOĞLU MOÇİN Ö,ÖZTİN A,ADIGÜZEL N,GÜNGÖR G "Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?." , ss.49 - 58, 2019. 10.14744/ejmo.2018.0089
ISNAD BERK TAKIR, HURİYE vd. "Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?". (2019), 49-58. https://doi.org/10.14744/ejmo.2018.0089
APA BERK TAKIR H, KARAKURT Z, ÇİFTASLAN GÖKŞENOĞLU N, Salturk C, YAZICIOĞLU MOÇİN Ö, ÖZTİN A, ADIGÜZEL N, GÜNGÖR G (2019). Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. Eurasian Journal of Medicine and Oncology, 3(1), 49 - 58. 10.14744/ejmo.2018.0089
Chicago BERK TAKIR HURİYE,KARAKURT ZÜHAL,ÇİFTASLAN GÖKŞENOĞLU Nezihe,Salturk Cuneyt,YAZICIOĞLU MOÇİN Özlem,ÖZTİN Ayşem Aşkım,ADIGÜZEL NALAN,GÜNGÖR Gökay Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. Eurasian Journal of Medicine and Oncology 3, no.1 (2019): 49 - 58. 10.14744/ejmo.2018.0089
MLA BERK TAKIR HURİYE,KARAKURT ZÜHAL,ÇİFTASLAN GÖKŞENOĞLU Nezihe,Salturk Cuneyt,YAZICIOĞLU MOÇİN Özlem,ÖZTİN Ayşem Aşkım,ADIGÜZEL NALAN,GÜNGÖR Gökay Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. Eurasian Journal of Medicine and Oncology, vol.3, no.1, 2019, ss.49 - 58. 10.14744/ejmo.2018.0089
AMA BERK TAKIR H,KARAKURT Z,ÇİFTASLAN GÖKŞENOĞLU N,Salturk C,YAZICIOĞLU MOÇİN Ö,ÖZTİN A,ADIGÜZEL N,GÜNGÖR G Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. Eurasian Journal of Medicine and Oncology. 2019; 3(1): 49 - 58. 10.14744/ejmo.2018.0089
Vancouver BERK TAKIR H,KARAKURT Z,ÇİFTASLAN GÖKŞENOĞLU N,Salturk C,YAZICIOĞLU MOÇİN Ö,ÖZTİN A,ADIGÜZEL N,GÜNGÖR G Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?. Eurasian Journal of Medicine and Oncology. 2019; 3(1): 49 - 58. 10.14744/ejmo.2018.0089
IEEE BERK TAKIR H,KARAKURT Z,ÇİFTASLAN GÖKŞENOĞLU N,Salturk C,YAZICIOĞLU MOÇİN Ö,ÖZTİN A,ADIGÜZEL N,GÜNGÖR G "Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?." Eurasian Journal of Medicine and Oncology, 3, ss.49 - 58, 2019. 10.14744/ejmo.2018.0089
ISNAD BERK TAKIR, HURİYE vd. "Intensive Care Unit and 12-month Mortality of Patients with Acute Respiratory Failure Admitted to the Intensive Care Unit: What is the Role of Comorbidities?". Eurasian Journal of Medicine and Oncology 3/1 (2019), 49-58. https://doi.org/10.14744/ejmo.2018.0089