The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study

Sever, Feyza; ANDIRAN ŞENAYLI, Yeşim; keskin, gülşen; KURT, Devrim Tanıl; Ozmert, Sengul; YARALI, NESE; Saydam, Sibel; Akin, Mine; Kirkiz, Serap

doi:10.14744/ejmo.2019.70524

The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study

Sengül ÖZMERT, (Ankara Sağlık Bilimleri Üniversitesi)

Feyza SEVER, (Ankara Sağlık Bilimleri Üniversitesi)

Devrim Tanıl KURT, (Ankara Sağlık Bilimleri Üniversitesi)

Sibel SAYDAM, (Ankara Sağlık Bilimleri Üniversitesi)

Gülşen KESKİN, (Ankara Sağlık Bilimleri Üniversitesi)

Yeşim ANDIRAN ŞENAYLI, (Ankara Sağlık Bilimleri Üniversitesi)

Mine AKIN, (Ankara Sağlık Bilimleri Üniversitesi)

Serap KİRKİZ, (Ankara Sağlık Bilimleri Üniversitesi)

Neşe YARALI (Ankara Sağlık Bilimleri Üniversitesi)

Eurasian Journal of Medicine and Oncology

4 2

Yıl: 2019 Cilt: 3 Sayı: 2 Sayfa Aralığı: 120 - 125 Metin Dili: İngilizce DOI: 10.14744/ejmo.2019.70524 İndeks Tarihi: 22-04-2020

The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study

Öz:

Objectives: The aim of the study was to evaluate reliability, efficiency and side effects of two different combinationsthat are ketamine-propofol and fentanyl-propofol, in pediatric hematology patients undergoing lumbar puncture (LP).Methods: A total of 100 paediatric cases, aged 4-14 years, who were planned to undergo LP procedure were administered two different sedo-analgesia protocols. An anesthetist administered ketamine 1 mg/kg intravascularly (iv) to theketamine group (K), then after 1 min 2 mg/kg propofol was administered iv. In the fentanyl group (F), 1 mcg/kg fentanylwas given and after 1 min 2 mg/kg propofol was administered iv. All patients were monitorized and the heart rate,blood pressure, oxygen saturation, number of LP attempts, the side effects and also additional doses and the physiciansatisfaction were recorded.Results: The requirement for additional doses was higher in Group F (p<0.001) and the physician satisfaction was lowerin Group F (p=0.021). When hemodynamic parameters were compared, the reduction in F group was determined asgreater than that in K group (p<0.01).Conclusion: Safe and effective sedation has been obtained with both protocols during LP. However, the ketaminepropofol combination had a lower requirement for additional doses and the physician satisfaction level was higher.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ozmert S, Sever F, KURT D, Saydam S, keskin g, ANDIRAN ŞENAYLI Y, Akin M, Kirkiz S, YARALI N (2019). The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. , 120 - 125. 10.14744/ejmo.2019.70524
Chicago	Ozmert Sengul,Sever Feyza,KURT Devrim Tanıl,Saydam Sibel,keskin gülşen,ANDIRAN ŞENAYLI Yeşim,Akin Mine,Kirkiz Serap,YARALI NESE The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. (2019): 120 - 125. 10.14744/ejmo.2019.70524
MLA	Ozmert Sengul,Sever Feyza,KURT Devrim Tanıl,Saydam Sibel,keskin gülşen,ANDIRAN ŞENAYLI Yeşim,Akin Mine,Kirkiz Serap,YARALI NESE The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. , 2019, ss.120 - 125. 10.14744/ejmo.2019.70524
AMA	Ozmert S,Sever F,KURT D,Saydam S,keskin g,ANDIRAN ŞENAYLI Y,Akin M,Kirkiz S,YARALI N The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. . 2019; 120 - 125. 10.14744/ejmo.2019.70524
Vancouver	Ozmert S,Sever F,KURT D,Saydam S,keskin g,ANDIRAN ŞENAYLI Y,Akin M,Kirkiz S,YARALI N The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. . 2019; 120 - 125. 10.14744/ejmo.2019.70524
IEEE	Ozmert S,Sever F,KURT D,Saydam S,keskin g,ANDIRAN ŞENAYLI Y,Akin M,Kirkiz S,YARALI N "The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study." , ss.120 - 125, 2019. 10.14744/ejmo.2019.70524
ISNAD	Ozmert, Sengul vd. "The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study". (2019), 120-125. https://doi.org/10.14744/ejmo.2019.70524

APA	Ozmert S, Sever F, KURT D, Saydam S, keskin g, ANDIRAN ŞENAYLI Y, Akin M, Kirkiz S, YARALI N (2019). The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. Eurasian Journal of Medicine and Oncology, 3(2), 120 - 125. 10.14744/ejmo.2019.70524
Chicago	Ozmert Sengul,Sever Feyza,KURT Devrim Tanıl,Saydam Sibel,keskin gülşen,ANDIRAN ŞENAYLI Yeşim,Akin Mine,Kirkiz Serap,YARALI NESE The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. Eurasian Journal of Medicine and Oncology 3, no.2 (2019): 120 - 125. 10.14744/ejmo.2019.70524
MLA	Ozmert Sengul,Sever Feyza,KURT Devrim Tanıl,Saydam Sibel,keskin gülşen,ANDIRAN ŞENAYLI Yeşim,Akin Mine,Kirkiz Serap,YARALI NESE The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. Eurasian Journal of Medicine and Oncology, vol.3, no.2, 2019, ss.120 - 125. 10.14744/ejmo.2019.70524
AMA	Ozmert S,Sever F,KURT D,Saydam S,keskin g,ANDIRAN ŞENAYLI Y,Akin M,Kirkiz S,YARALI N The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. Eurasian Journal of Medicine and Oncology. 2019; 3(2): 120 - 125. 10.14744/ejmo.2019.70524
Vancouver	Ozmert S,Sever F,KURT D,Saydam S,keskin g,ANDIRAN ŞENAYLI Y,Akin M,Kirkiz S,YARALI N The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study. Eurasian Journal of Medicine and Oncology. 2019; 3(2): 120 - 125. 10.14744/ejmo.2019.70524
IEEE	Ozmert S,Sever F,KURT D,Saydam S,keskin g,ANDIRAN ŞENAYLI Y,Akin M,Kirkiz S,YARALI N "The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study." Eurasian Journal of Medicine and Oncology, 3, ss.120 - 125, 2019. 10.14744/ejmo.2019.70524
ISNAD	Ozmert, Sengul vd. "The Safety and Efficacy of Propofol Combinations with Ketamine or Fentanyl in Lumbar Puncture Application in Children with Haematological Diseases: A Prospective, Randomised, Single-Blinded Study". Eurasian Journal of Medicine and Oncology 3/2 (2019), 120-125. https://doi.org/10.14744/ejmo.2019.70524