Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy
Yıl: 2019 Cilt: 51 Sayı: 1 Sayfa Aralığı: 70 - 74 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2019.18299 İndeks Tarihi: 22-04-2020
Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy
Öz: Objective: This study aims to compare the effects of different inhalation anesthetics on oxidative status bymeasuring thiol-disulfide homeostasis in laparoscopic cholecystectomy surgeries. The effect of inhaler agentson thiol-disulfide homeostasis that shows the oxidative status in laparoscopic cholecystectomy is unknown.Materials and Methods: In this study, 71 patients planned to undergo laparoscopic cholecystectomy undergeneral anesthesia were included. They were divided into two groups: desflurane (group D, n: 35) and sevoflurane(group S, n: 36). Blood samples were taken before induction (T1), at 30th minute of insufflation (T2)(30th min of ischemia), and at 30th min postdeflation (T3) (30th min of reperfusion). The native thiols (–SH)and total thiols (–SH+ –SS) were determined. The amounts of disulfide (–SS), disulfide/native thiol percentratios (–SS/–SH), disulfide/total thiol percent ratios (–SS/–SH+–SS), and native thiol/total thiol percent ratios(–SH/–SH+ –SS) were calculated.Results: In the sevoflurane group, preoperative values and intraoperative 30th-minute SS–SH ratio weresignificantly reduced (p=0.017). In the desflurane group, intraoperative native thiol values and postdeflationlevels significantly decreased compared to those in the preoperative values (p<0.001).Conclusion: We think that the usage of sevoflurane was more protective in terms of the oxidative damageoccurring during laparoscopic surgery.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Nesek-Adam V, Vnuk D, Rasić Z, Rumenjak V, Kos J. Krstonijević, Z. Comparison of the effects of low intraabdominal pressure and pentoxifylline on oxidative stress during CO2 pneumoperitoneum in rabbits. Eur Surg Res 2009; 43: 330-7. [CrossRef]
- 2. Biler A, Yucebilgin S, Sendag F, et al. The effects of different intraabdominal pressure protocols in laparoscopic procedures on oxidative stress markers and morphology in rat ovaries. Adv Clin Exp Med 2014; 23: 885-92. [CrossRef]
- 3. Sammour T, Mittal A, Loveday BP, et al.Systematic review of oxidative stress associated with pneumoperitoneum. Br J Surg 2009; 96: 836-50. [CrossRef]
- 4. Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 2014; 47: 326-32. [CrossRef]
- 5. Erbasa M, Demiraran Y, Yildirim HA, et al. Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia Rev Bras Anestesiol 2015; 65: 68-72. [CrossRef]
- 6. Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 2000; 72: 653-69. [CrossRef]
- 7. Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010; 48: 749-62. [CrossRef]
- 8. Biswas S, Chida AS, Rahman I. Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol 2006; 71: 551-64. [CrossRef]
- 9. Polat M, Ozcan O, Sahan L, et al. Changes in Thiol-Disulfide Homeostasis of the Body to Surgical Trauma in Laparoscopic Cholecystectomy Patients. J Laparoendosc Adv Surg Tech A 2016; 26: 992-6. [CrossRef]
- 10. Koksal GM, Sayilgan C, Aydin S, Uzun H, Oz H. The effects of sevoflurane and desflurane on lipid peroxidation during laparo-scopic cholecystectomy. Eur J Anaesthesiol 2004; 21: 217-20. [CrossRef]
- 11. Jakimowicz J, Stultiëns G, Smulders F. Laparoscopic insufflation of the abdomen reduces portal venous flow. Surg Endosc 1998; 12: 129-32. [CrossRef]
- 12. Polat C, Kahraman A, Yilmaz S, et al. A comparison of the oxidative stress response and antioxidant capacity of open and laparoscopic hernia repairs. J Laparoendosc Adv Surg Tech A 2003; 13: 167-73. [CrossRef]
- 13. Schilling MK, Redaelli C, Krahenbuhl L, Signer C, Buchler MW. Splanchnic microcirculatory changes during CO2 laparoscopy. J Am Coll Surg 1997; 184: 378-82.
- 14. Schilling T, Kozian A, Senturk M, et al. Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients. Anesthesiology 2011; 115: 65-74. [CrossRef]
- 15. Sivanna U, Joshi S, Babu B, Jagadeesh AM. A comparative study of pharmacological myocardial protection between sevoflurane and desflurane at anaesthestic doses in patients undergoing off pump coronary artery bypass grafting surgery. Indian J Anaesth 2015; 59: 282-6. [CrossRef]
- 16. Luo C, Yuan D, Zhaon W, et al.Sevoflurane ameliorates intestinal ischemia-reperfusion-induced lung injury by inhibiting the synergistic action between mast cell activation and oxidative stress. Molecular Medicine Reports 2015; 12: 1082-90. [CrossRef]
- 17. Zhang Y, Zhang F, Meng C, et al. Inhibition of Sevoflurane Postconditioning Against Cerebral Ischemia Reperfusion-Induced Oxidative Injury in Rats. Molecules 2012; 17: 341-54. [CrossRef]
- 18. Sivaci R, Kahraman A, Serteser M, Sahin DA, Dilek ON. Cytotoxic effects of volatile anesthetics with free radicals undergoing laparoscopic surgery. Clin Biochem 2006; 39: 293-8. [CrossRef]
- 19. Yalçın Ş, Özgencil E, Serdaroglu H, Oba Ş, Enön S, Demiralp S. Anesthetics modulate oxidative stress during one-lung ventilation in lung cancer patients: Comparison of target-controlled propofol infusion and desflurane. Afr J Pharm Pharmacol 2012; 6: 407-11.
- 20. Emir H, Akman M, Belce A, Gumustas K, Soylet Y. Is intestinal ischemia a risk of laparoscopy? An experimental study in rabbits. Eur J Pediatr Surg 2001; 11: 158-62. [CrossRef]
- 21. Glantzounis GK, Tselepis AD, Tambaki AP, et al. Laparoscopic surgery-induced changes in oxidative stress markers in human plasma. Surg Endosc 2001; 15: 1315-9. [CrossRef]
- 22. Bentes de Souza AM, Rogers MS,Wang CC, Yuen PM, Ng PS. Comparison of peritoneal oxidative stress during laparoscopy and laparotomy. J Am Assoc Gynecol Laparosc 2003; 10: 65-74. [CrossRef]
| APA | DUMANLI OZCAN A, DÖĞER C, OZTÜRK L, YUNGUL A, KURTSAHİN M, NEŞELİOĞLU S, Ergin Tuncay M, BUT A (2019). Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. , 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| Chicago | DUMANLI OZCAN Ayça Tuba,DÖĞER Cihan,OZTÜRK LEVENT,YUNGUL Aysun,KURTSAHİN Müge,NEŞELİOĞLU Salim,Ergin Tuncay Merve,BUT Abdulkadir Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. (2019): 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| MLA | DUMANLI OZCAN Ayça Tuba,DÖĞER Cihan,OZTÜRK LEVENT,YUNGUL Aysun,KURTSAHİN Müge,NEŞELİOĞLU Salim,Ergin Tuncay Merve,BUT Abdulkadir Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. , 2019, ss.70 - 74. 10.5152/eurasianjmed.2019.18299 |
| AMA | DUMANLI OZCAN A,DÖĞER C,OZTÜRK L,YUNGUL A,KURTSAHİN M,NEŞELİOĞLU S,Ergin Tuncay M,BUT A Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. . 2019; 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| Vancouver | DUMANLI OZCAN A,DÖĞER C,OZTÜRK L,YUNGUL A,KURTSAHİN M,NEŞELİOĞLU S,Ergin Tuncay M,BUT A Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. . 2019; 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| IEEE | DUMANLI OZCAN A,DÖĞER C,OZTÜRK L,YUNGUL A,KURTSAHİN M,NEŞELİOĞLU S,Ergin Tuncay M,BUT A "Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy." , ss.70 - 74, 2019. 10.5152/eurasianjmed.2019.18299 |
| ISNAD | DUMANLI OZCAN, Ayça Tuba vd. "Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy". (2019), 70-74. https://doi.org/10.5152/eurasianjmed.2019.18299 |
| APA | DUMANLI OZCAN A, DÖĞER C, OZTÜRK L, YUNGUL A, KURTSAHİN M, NEŞELİOĞLU S, Ergin Tuncay M, BUT A (2019). Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. Eurasian Journal of Medicine, 51(1), 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| Chicago | DUMANLI OZCAN Ayça Tuba,DÖĞER Cihan,OZTÜRK LEVENT,YUNGUL Aysun,KURTSAHİN Müge,NEŞELİOĞLU Salim,Ergin Tuncay Merve,BUT Abdulkadir Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. Eurasian Journal of Medicine 51, no.1 (2019): 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| MLA | DUMANLI OZCAN Ayça Tuba,DÖĞER Cihan,OZTÜRK LEVENT,YUNGUL Aysun,KURTSAHİN Müge,NEŞELİOĞLU Salim,Ergin Tuncay Merve,BUT Abdulkadir Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. Eurasian Journal of Medicine, vol.51, no.1, 2019, ss.70 - 74. 10.5152/eurasianjmed.2019.18299 |
| AMA | DUMANLI OZCAN A,DÖĞER C,OZTÜRK L,YUNGUL A,KURTSAHİN M,NEŞELİOĞLU S,Ergin Tuncay M,BUT A Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. Eurasian Journal of Medicine. 2019; 51(1): 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| Vancouver | DUMANLI OZCAN A,DÖĞER C,OZTÜRK L,YUNGUL A,KURTSAHİN M,NEŞELİOĞLU S,Ergin Tuncay M,BUT A Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy. Eurasian Journal of Medicine. 2019; 51(1): 70 - 74. 10.5152/eurasianjmed.2019.18299 |
| IEEE | DUMANLI OZCAN A,DÖĞER C,OZTÜRK L,YUNGUL A,KURTSAHİN M,NEŞELİOĞLU S,Ergin Tuncay M,BUT A "Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy." Eurasian Journal of Medicine, 51, ss.70 - 74, 2019. 10.5152/eurasianjmed.2019.18299 |
| ISNAD | DUMANLI OZCAN, Ayça Tuba vd. "Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy". Eurasian Journal of Medicine 51/1 (2019), 70-74. https://doi.org/10.5152/eurasianjmed.2019.18299 |
