Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children

Objective: No large study has been conducted to date to compare the effectiveness of prednisolone, alendronate and pamidronate asfirst-line treatment in children with hypercalcemia due to vitamin D intoxication. The aim was to perform a multicenter, retrospectivestudy assessing clinical characteristics and treatment results.Methods: A standard questionnaire was uploaded to an online national database system to collect data on children with hypercalcemia(serum calcium level >10.5 mg/dL) due to vitamin D intoxication [serum 25-hydroxyvitamin D (25(OH)D) level >150 ng/mL] who weretreated in pediatric endocrinology clinics.Results: Seventy-four children [median (range) age 1.06 (0.65-1.60) years, 45 males (61%) from 11 centers] were included. High-dosevitamin D intake was evident in 77% of the cases. At diagnosis, serum calcium, phosphorus, alkaline phosphatase, 25(OH)D andparathyroid hormone concentrations were 15±3.2 mg/dL, 5.2±1.2 mg/dL, 268±132 IU/L, 322 (236-454) ng/mL, and 5.5 (3-10.5) pg/mL, respectively. Calcium levels showed moderate correlation with 25(OH)D levels (rs=0.402, p<0.001). Patients were designatedinto five groups according to the initial specific treatment regimens (hydration-only, prednisolone, alendronate, pamidronate, and combination). Need for another type of specific drug treatment was higher in children who initially received prednisolone (p<0.001).Recurrence rate of hypercalcemia was significantly lower in children who were treated with pamidronate (p=0.02).Conclusion: Prednisolone is less effective in the treatment of children with severe hypercalcaemia secondary to vitamin D intoxicationand timely implementation of other treatment regimens should be considered.

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Demir K, DÖNERAY H, KARA C, Atay Z, Çetinkaya S, Cayir A, ANIK A, Eren E, UÇAKTÜRK A, Can Yilmaz G, TÖREL ERGÜR A, Kendirci M, aycan z, Bereket A, AYDIN H, Orbak Z, ÖZKAN B (2019). Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. , 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
Chicago	Demir Korcan,DÖNERAY Hakan,KARA Cengiz,Atay Zeynep,Çetinkaya Semra,Cayir Atilla,ANIK AHMET,Eren Erdal,UÇAKTÜRK Ahmet,Can Yilmaz Gulay,TÖREL ERGÜR Ayça,Kendirci Mustafa,aycan zehra,Bereket Abdullah,AYDIN HASAN MURAT,Orbak Zerrin,ÖZKAN Behzat Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. (2019): 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
MLA	Demir Korcan,DÖNERAY Hakan,KARA Cengiz,Atay Zeynep,Çetinkaya Semra,Cayir Atilla,ANIK AHMET,Eren Erdal,UÇAKTÜRK Ahmet,Can Yilmaz Gulay,TÖREL ERGÜR Ayça,Kendirci Mustafa,aycan zehra,Bereket Abdullah,AYDIN HASAN MURAT,Orbak Zerrin,ÖZKAN Behzat Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. , 2019, ss.140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
AMA	Demir K,DÖNERAY H,KARA C,Atay Z,Çetinkaya S,Cayir A,ANIK A,Eren E,UÇAKTÜRK A,Can Yilmaz G,TÖREL ERGÜR A,Kendirci M,aycan z,Bereket A,AYDIN H,Orbak Z,ÖZKAN B Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. . 2019; 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
Vancouver	Demir K,DÖNERAY H,KARA C,Atay Z,Çetinkaya S,Cayir A,ANIK A,Eren E,UÇAKTÜRK A,Can Yilmaz G,TÖREL ERGÜR A,Kendirci M,aycan z,Bereket A,AYDIN H,Orbak Z,ÖZKAN B Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. . 2019; 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
IEEE	Demir K,DÖNERAY H,KARA C,Atay Z,Çetinkaya S,Cayir A,ANIK A,Eren E,UÇAKTÜRK A,Can Yilmaz G,TÖREL ERGÜR A,Kendirci M,aycan z,Bereket A,AYDIN H,Orbak Z,ÖZKAN B "Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children." , ss.140 - 148, 2019. 10.4274/jcrpe.galenos.2018.2018.0131
ISNAD	Demir, Korcan vd. "Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children". (2019), 140-148. https://doi.org/10.4274/jcrpe.galenos.2018.2018.0131

APA	Demir K, DÖNERAY H, KARA C, Atay Z, Çetinkaya S, Cayir A, ANIK A, Eren E, UÇAKTÜRK A, Can Yilmaz G, TÖREL ERGÜR A, Kendirci M, aycan z, Bereket A, AYDIN H, Orbak Z, ÖZKAN B (2019). Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. Journal of Clinical Research in Pediatric Endocrinology, 11(2), 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
Chicago	Demir Korcan,DÖNERAY Hakan,KARA Cengiz,Atay Zeynep,Çetinkaya Semra,Cayir Atilla,ANIK AHMET,Eren Erdal,UÇAKTÜRK Ahmet,Can Yilmaz Gulay,TÖREL ERGÜR Ayça,Kendirci Mustafa,aycan zehra,Bereket Abdullah,AYDIN HASAN MURAT,Orbak Zerrin,ÖZKAN Behzat Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. Journal of Clinical Research in Pediatric Endocrinology 11, no.2 (2019): 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
MLA	Demir Korcan,DÖNERAY Hakan,KARA Cengiz,Atay Zeynep,Çetinkaya Semra,Cayir Atilla,ANIK AHMET,Eren Erdal,UÇAKTÜRK Ahmet,Can Yilmaz Gulay,TÖREL ERGÜR Ayça,Kendirci Mustafa,aycan zehra,Bereket Abdullah,AYDIN HASAN MURAT,Orbak Zerrin,ÖZKAN Behzat Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. Journal of Clinical Research in Pediatric Endocrinology, vol.11, no.2, 2019, ss.140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
AMA	Demir K,DÖNERAY H,KARA C,Atay Z,Çetinkaya S,Cayir A,ANIK A,Eren E,UÇAKTÜRK A,Can Yilmaz G,TÖREL ERGÜR A,Kendirci M,aycan z,Bereket A,AYDIN H,Orbak Z,ÖZKAN B Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. Journal of Clinical Research in Pediatric Endocrinology. 2019; 11(2): 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
Vancouver	Demir K,DÖNERAY H,KARA C,Atay Z,Çetinkaya S,Cayir A,ANIK A,Eren E,UÇAKTÜRK A,Can Yilmaz G,TÖREL ERGÜR A,Kendirci M,aycan z,Bereket A,AYDIN H,Orbak Z,ÖZKAN B Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children. Journal of Clinical Research in Pediatric Endocrinology. 2019; 11(2): 140 - 148. 10.4274/jcrpe.galenos.2018.2018.0131
IEEE	Demir K,DÖNERAY H,KARA C,Atay Z,Çetinkaya S,Cayir A,ANIK A,Eren E,UÇAKTÜRK A,Can Yilmaz G,TÖREL ERGÜR A,Kendirci M,aycan z,Bereket A,AYDIN H,Orbak Z,ÖZKAN B "Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children." Journal of Clinical Research in Pediatric Endocrinology, 11, ss.140 - 148, 2019. 10.4274/jcrpe.galenos.2018.2018.0131
ISNAD	Demir, Korcan vd. "Comparison of Treatment Regimens in Management of Severe Hypercalcemia Due to Vitamin D Intoxication in Children". Journal of Clinical Research in Pediatric Endocrinology 11/2 (2019), 140-148. https://doi.org/10.4274/jcrpe.galenos.2018.2018.0131