TY  - JOUR
TI  - Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with Haemophilia
AB  - Objective: Increased risk of unfavorable cardiovascular risk factors has been recognised in ageing patients with haemophilia (PwH), butneeds further studies in younger patients. The purpose of this study was to assess obesity, hypertension (HT), metabolic variables, insulinresistance and metabolic syndrome in young PwH.Methods: Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included in the study.Anthropometric measurements, blood pressure (BP), fasting glucose and insulin levels, serum lipids and diet were evaluated. Themetabolic syndrome was defined according to the criteria of the International Diabetes Federation for pediatric and adult age groups.Results: The mean age of PwH was 21±9 years (range, 6-40 years). Of those ≥18 years, 46% were were obese/overweight while therewere no obese/overweight cases in the <18 year-old patients. Obesity was more prevalent in PwH with arthropathy (p=0.017). Sevenpercent of the PwH between 10 and 18 years-old and 25% of those ≥18 years had metabolic syndrome. There was no differencein metabolic syndrome frequency between PwH and controls >10 years-old (19.5% vs 10% respectively, p=0.34). Fifty percent ofthe PwH ≥18 years-old had elevated BP or HT. Fasting blood glucose levels of PwH were significantly higher compared to controls(p=0.02).Conclusion: Our study showed that obesity, HT and metabolic syndrome are frequent problems, especially in PwH with arthropathy.Early prevention and management of overweight, obesity and their sequelae must be addressed in clinical practice in order to maximizethe overall health of the haemophilia population.
AU  - Koc, Basak
AU  - Yildiz, Melek
AU  - Onal, Hasan
AU  - ELİUZ TİPİCİ, BEYZA
AU  - Özdemir, Nihal
AU  - Zulfikar, Bulent
DO  - 10.4274/jcrpe.galenos.2018.2018.0292
PY  - 2019
JO  - Journal of Clinical Research in Pediatric Endocrinology
VL  - 11
IS  - 2
SN  - 1308-5727
SP  - 173
EP  - 180
DB  - TRDizin
UR  - http://search/yayin/detay/334356
ER  -