Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki

Acar, Ceren; VAİZOĞLU, Reika Dilara

doi:10.5222/TMCD.2019.001

Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki

Reika Dilara VAİZOĞLU, (İnönü Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Malatya, Türkiye)

Ceren ACAR (İnönü Üniversitesi, Fen Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, Malatya, Türkiye)

Türk Mikrobiyoloji Cemiyeti Dergisi

8 1

Yıl: 2019 Cilt: 49 Sayı: 1 Sayfa Aralığı: 1 - 10 Metin Dili: Türkçe DOI: 10.5222/TMCD.2019.001 İndeks Tarihi: 29-04-2020

Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki

Öz:

Dünyadaki başlıca sağlık sorunlarından biri olan tüberküloz, her yıl çok sayıda ölüme nedenolmaktadır. Dünya Sağlık Örgütü’nün (DSÖ) 2018 raporuna göre 2017 yılında 6.7 milyon yenitüberküloz olgusu bildirilmiştir. Hastalık etkeni, kişileri enfekte ettikten sonra çok uzun sürelatent evrede kalabilmektedir. Enfekte olan kişilerden bazıları hasta olurken, bazı kişilerde isehastalık hiçbir zaman gelişmemekte hatta bunların yaklaşık %90’ı bağışıklık sisteminin verdiğiyanıtla kendiliğinden iyileşmektedir. Birçok enfektif hastalıkta olduğu gibi, enfekte olan kişisayısı ve hasta olan kişi sayısı arasındaki farklılığa konakçı savunması ve organizmanın virülansı arasındaki denge farklılıkları neden olmaktadır. Yapılan çalışmalarda, bu farklılığın nedeniçoğunlukla, konağın bağışıklık sisteminin durumu ile ilişkilendirilmiş ancak yeterli bir yanıtolarak görülmemiştir. Bu durumda, enfektif hastalıklarla konak arasındaki ilişkiyi anlayabilmekiçin enfektif ajanlara verilen yanıtın genetik temellerinin araştırılması gerekmektedir. Bu derlemede Mycobacterium tuberculosis’e immun yanıtta ya da yatkınlıkta söz konusu olan TLRgenlerindeki polimorfizmlerin etkisini inceleyen çalışmalar özetlenmiştir.

Anahtar Kelime:

Konular: Mikrobiyoloji

The Relationship Between Tuberculosis and TLR Gene Polymorphisms

Öz:

Tuberculosis, one of the major health problems in the world, causes many deaths every year. According to the 2018 World Health Organization (WHO) report, 6.7 million new tuberculosis cases were reported in 2017. The disease can remain in the latent phase for a very long time after infecting the affected individual. While some of the infected people contract the disease, while the others never develop the disease; even about 90% of the contracted people improve and get well by the immune system’s response. As in many infectious diseases, the difference between the number of infected people and the number of people with the disease is due differences in balance between the host defense and the virulence of the organism. In the studies conducted; this difference was mostly attributed to the state of the immune system of the host, but this is not accepted as an adequate response. With these terms, the genetic basis of the response to infectious agents needs to be investigated in order to understand the relationship between infectious diseases and the host. In this review we have summarized the studies on the effect of polymorphisms of TLR genes which are involved in the immune response and the susceptibility to Mycobacterium tuberculosis.

Anahtar Kelime:

Konular: Mikrobiyoloji

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	VAİZOĞLU R, Acar C (2019). Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. , 1 - 10. 10.5222/TMCD.2019.001
Chicago	VAİZOĞLU Reika Dilara,Acar Ceren Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. (2019): 1 - 10. 10.5222/TMCD.2019.001
MLA	VAİZOĞLU Reika Dilara,Acar Ceren Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. , 2019, ss.1 - 10. 10.5222/TMCD.2019.001
AMA	VAİZOĞLU R,Acar C Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. . 2019; 1 - 10. 10.5222/TMCD.2019.001
Vancouver	VAİZOĞLU R,Acar C Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. . 2019; 1 - 10. 10.5222/TMCD.2019.001
IEEE	VAİZOĞLU R,Acar C "Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki." , ss.1 - 10, 2019. 10.5222/TMCD.2019.001
ISNAD	VAİZOĞLU, Reika Dilara - Acar, Ceren. "Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki". (2019), 1-10. https://doi.org/10.5222/TMCD.2019.001

APA	VAİZOĞLU R, Acar C (2019). Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. Türk Mikrobiyoloji Cemiyeti Dergisi, 49(1), 1 - 10. 10.5222/TMCD.2019.001
Chicago	VAİZOĞLU Reika Dilara,Acar Ceren Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. Türk Mikrobiyoloji Cemiyeti Dergisi 49, no.1 (2019): 1 - 10. 10.5222/TMCD.2019.001
MLA	VAİZOĞLU Reika Dilara,Acar Ceren Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. Türk Mikrobiyoloji Cemiyeti Dergisi, vol.49, no.1, 2019, ss.1 - 10. 10.5222/TMCD.2019.001
AMA	VAİZOĞLU R,Acar C Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. Türk Mikrobiyoloji Cemiyeti Dergisi. 2019; 49(1): 1 - 10. 10.5222/TMCD.2019.001
Vancouver	VAİZOĞLU R,Acar C Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki. Türk Mikrobiyoloji Cemiyeti Dergisi. 2019; 49(1): 1 - 10. 10.5222/TMCD.2019.001
IEEE	VAİZOĞLU R,Acar C "Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki." Türk Mikrobiyoloji Cemiyeti Dergisi, 49, ss.1 - 10, 2019. 10.5222/TMCD.2019.001
ISNAD	VAİZOĞLU, Reika Dilara - Acar, Ceren. "Tüberküloz ve TLR Gen Polimorfizmleri Arasındaki İlişki". Türk Mikrobiyoloji Cemiyeti Dergisi 49/1 (2019), 1-10. https://doi.org/10.5222/TMCD.2019.001