The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester
Yıl: 2020 Cilt: 44 Sayı: 2 Sayfa Aralığı: 404 - 417 Metin Dili: Diğer DOI: 10.3906/vet-1906-15 İndeks Tarihi: 30-04-2020
The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester
Öz: The main aim of the present study was to examine the neurotoxic effects of prenatal exposure to varying doses of diclofenacsodium (DS) on the rat hippocampus. Twenty-eight Wistar albino adult female rats weighing 280–300 g were initially used for pregnancy.When vaginal plaques were seen in female rats, it was accepted as the 0th day of pregnancy. Female rats were divided into five maingroups; pure control, saline, low dose DS (3.6 mg/kg), moderate dose DS (9 mg/kg), and high dose DS (18 mg/kg). They were exposed tothese treatments during their gestation. After birth, all newborn male rats were euthanized by overdose anesthesia on the 7th postnatalday. Histological and stereological techniques were used for analyzing tissue samples. The stereological analyses in this study showedthat the number of neurons in the hippocampus may be reduced due to the use of DS. Histological investigation of the drug-treatedgroups showed significant cell loss compared to the control. Darkly stained nuclei of the neurons in the high dose group compared to theother groups were also obvious. When the results are evaluated, it can be concluded that the use of diclofenac sodium during pregnancymay have teratogenic effects on the development of the nervous system.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ELİBOL E, KAPLAN S, ALTUN G, AKSOY A, ZUHAL B (2020). The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. , 404 - 417. 10.3906/vet-1906-15 |
| Chicago | ELİBOL Ebru,KAPLAN Süleyman,ALTUN Gamze,AKSOY Abdurrahman,ZUHAL BERRİN The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. (2020): 404 - 417. 10.3906/vet-1906-15 |
| MLA | ELİBOL Ebru,KAPLAN Süleyman,ALTUN Gamze,AKSOY Abdurrahman,ZUHAL BERRİN The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. , 2020, ss.404 - 417. 10.3906/vet-1906-15 |
| AMA | ELİBOL E,KAPLAN S,ALTUN G,AKSOY A,ZUHAL B The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. . 2020; 404 - 417. 10.3906/vet-1906-15 |
| Vancouver | ELİBOL E,KAPLAN S,ALTUN G,AKSOY A,ZUHAL B The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. . 2020; 404 - 417. 10.3906/vet-1906-15 |
| IEEE | ELİBOL E,KAPLAN S,ALTUN G,AKSOY A,ZUHAL B "The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester." , ss.404 - 417, 2020. 10.3906/vet-1906-15 |
| ISNAD | ELİBOL, Ebru vd. "The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester". (2020), 404-417. https://doi.org/10.3906/vet-1906-15 |
| APA | ELİBOL E, KAPLAN S, ALTUN G, AKSOY A, ZUHAL B (2020). The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. Turkish Journal of Veterinary and Animal Sciences, 44(2), 404 - 417. 10.3906/vet-1906-15 |
| Chicago | ELİBOL Ebru,KAPLAN Süleyman,ALTUN Gamze,AKSOY Abdurrahman,ZUHAL BERRİN The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. Turkish Journal of Veterinary and Animal Sciences 44, no.2 (2020): 404 - 417. 10.3906/vet-1906-15 |
| MLA | ELİBOL Ebru,KAPLAN Süleyman,ALTUN Gamze,AKSOY Abdurrahman,ZUHAL BERRİN The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. Turkish Journal of Veterinary and Animal Sciences, vol.44, no.2, 2020, ss.404 - 417. 10.3906/vet-1906-15 |
| AMA | ELİBOL E,KAPLAN S,ALTUN G,AKSOY A,ZUHAL B The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. Turkish Journal of Veterinary and Animal Sciences. 2020; 44(2): 404 - 417. 10.3906/vet-1906-15 |
| Vancouver | ELİBOL E,KAPLAN S,ALTUN G,AKSOY A,ZUHAL B The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester. Turkish Journal of Veterinary and Animal Sciences. 2020; 44(2): 404 - 417. 10.3906/vet-1906-15 |
| IEEE | ELİBOL E,KAPLAN S,ALTUN G,AKSOY A,ZUHAL B "The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester." Turkish Journal of Veterinary and Animal Sciences, 44, ss.404 - 417, 2020. 10.3906/vet-1906-15 |
| ISNAD | ELİBOL, Ebru vd. "The effects of different doses of diclofenac sodium on newborn rat hippocampus exposed during the third trimester". Turkish Journal of Veterinary and Animal Sciences 44/2 (2020), 404-417. https://doi.org/10.3906/vet-1906-15 |
