TY  - JOUR
TI  - Importance of Hpv Positivity in Squamous Cell Head and Neck Cancer
AB  - The last three decades provided new insights into the discovery of the entity related to several strainsof human papillomavirus (HPV). The viral cause of HPV, primarily found in the oropharynx, was officially recognized by the World Health Organization in 2007. While epidemiologic studies around theworld showed an increased incidence of HPV-related heads and neck cancers (HNC), they also established a photo robot of a typical person suffering from HPV: younger white man, suffering from a nonkeratinized type of squamous cell carcinoma, rarely being seen as heavy smoker and/or drinker. Thepatient with specific sexual behavior pattern usually carried low T and high N burden, HPV16 beingdetected in the vast majority of HPV+ tumors, mostly in the oropharynx. It was also recognized thatHPV-related cancers seem to have a better prognosis than their HPV-unrelated counterparts. This observation served as an important starting point for clinical studies aiming first to identify different riskgroups and then to design various de-intensification treatment strategies which aimed to maintain highsuccess rate with e.g. lower radiotherapy and/or chemotherapy doses while decreasing side effects suchdeintensified treatment strategies should bring. This review summarizes the most important aspects ofHPV-related HNC.
AU  - FİLİPOVİC, Nenad
AU  - DUBİNSKY, Pavol
AU  - ÖZYİĞİT, Gökhan
AU  - JEREMİC, Branislav
DO  - 10.5505/tjo.2019.2079
PY  - 2019
JO  - Türk Onkoloji Dergisi
VL  - 34
IS  - 3
SN  - 1300-7467
SP  - 204
EP  - 214
DB  - TRDizin
UR  - http://search/yayin/detay/335243
ER  -