Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Yıl: 2019 Cilt: 25 Sayı: 2 Sayfa Aralığı: 49 - 52 Metin Dili: İngilizce DOI: 10.4274/tod.galenos.2019.16023 İndeks Tarihi: 05-05-2020

Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?

Öz:
Objective: Although the pathophysiology of Fibromyalgia syndrome (FMS) has not yet been completely elucidated, it has been suggestedthat inflammation and endothelial dysfunction occur in patients with FMS. In recent years, endocan has been reported as an importantbiomarker for inflammation and endothelial dysfunction. It is important to assess carotid intima-media thickness (CIMT) in the evaluation ofearly atherosclerotic vascular diseases. In this study, we investigated this mechanism by measuring serum endocan levels and CIMT in patientswith FMS and evaluated whether there is a correlation between them.Materials and Methods: Serum samples collected from 40 female patients diagnosed with FMS (the patient group) for the first time and40 healthy female participants’ (the control group) endocan levels and CIMT ultrasonography were investigated, and the values of the twogroups were compared.Results: Serum endocan levels and CIMT results were significantly higher in the patient group than in the control group (p<0.001). Inaddition, a very weak correlation was found between CIMT and endocan levels in patients with FMS.Conclusion: Increased subclinical inflammation, endothelial dysfunction, and early atherosclerosis play an important role in thepathophysiology of FMS. Increased endocan levels, CIMT, and the correlation between them will contribute to elucidating this mechanism.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Romatoloji

Fibromiyaljili Hastalarda Serum Endokan Düzeyleri ile Karotis İntima-medya Kalınlığı Arasında İlişki Var mı?

Öz:
Amaç: Fibromiyaljinin patofizyolojisi henüz tam olarak aydınlatılmamış olmakla birlikte, fibromiyaljili hastalarda enflamasyon ve endotel disfonksiyonunun ortaya çıktığı ileri sürülmüştür. Son yıllarda, endokan enflamasyon ve endotel disfonksiyonu için önemli bir biyobelirteç olarak bildirilmiştir. Erken aterosklerotik vasküler hastalıkları değerlendirmede karotis intima media-kalınlığının (KİMK) değerlendirilmesi önemlidir. Bu çalışmada, fibromiyalji hastalarında serum endokan düzeylerini ve KİMK’yi ölçerek bu mekanizmayı araştırdık, aralarında bir korelasyon olup olmadığını değerlendirdik. Gereç ve Yöntem: İlk kez fibromiyalji tanısı alan 40 kadın hastadan toplanan serum örnekleri ve 40 sağlıklı kadın endokan düzeyleri ve KİMK ultrasonografi ile incelendi ve iki grubun değerleri karşılaştırıldı. Bulgular: Hasta grubunda serum endokan seviyeleri ve KİMK sonuçları kontrol grubuna göre anlamlı olarak yüksek olarak bulunmuştur (p<0,001). Ayrıca FMS’li hastalarda KİMK ile endokan seviyesi arasında çok zayıf bir korelasyon görüldü. Sonuç: Fibromiyaljinin patofizyolojisinde artmış subklinik enflamasyon, endotelyal disfonksiyon ve erken ateroskleroz önemlidir. Artan endokan düzeyi, KİMK ve aralarında korelasyon görülmesi bu mekanizmayı aydınlatmaya katkı sağlar.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Romatoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA bağcıer f, Tufanoğlu F, KADIÇEŞME Ö (2019). Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. , 49 - 52. 10.4274/tod.galenos.2019.16023
Chicago bağcıer fatih,Tufanoğlu Fatih Hakan,KADIÇEŞME Özgür Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. (2019): 49 - 52. 10.4274/tod.galenos.2019.16023
MLA bağcıer fatih,Tufanoğlu Fatih Hakan,KADIÇEŞME Özgür Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. , 2019, ss.49 - 52. 10.4274/tod.galenos.2019.16023
AMA bağcıer f,Tufanoğlu F,KADIÇEŞME Ö Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. . 2019; 49 - 52. 10.4274/tod.galenos.2019.16023
Vancouver bağcıer f,Tufanoğlu F,KADIÇEŞME Ö Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. . 2019; 49 - 52. 10.4274/tod.galenos.2019.16023
IEEE bağcıer f,Tufanoğlu F,KADIÇEŞME Ö "Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?." , ss.49 - 52, 2019. 10.4274/tod.galenos.2019.16023
ISNAD bağcıer, fatih vd. "Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?". (2019), 49-52. https://doi.org/10.4274/tod.galenos.2019.16023
APA bağcıer f, Tufanoğlu F, KADIÇEŞME Ö (2019). Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. Türk Osteoporoz Dergisi, 25(2), 49 - 52. 10.4274/tod.galenos.2019.16023
Chicago bağcıer fatih,Tufanoğlu Fatih Hakan,KADIÇEŞME Özgür Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. Türk Osteoporoz Dergisi 25, no.2 (2019): 49 - 52. 10.4274/tod.galenos.2019.16023
MLA bağcıer fatih,Tufanoğlu Fatih Hakan,KADIÇEŞME Özgür Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. Türk Osteoporoz Dergisi, vol.25, no.2, 2019, ss.49 - 52. 10.4274/tod.galenos.2019.16023
AMA bağcıer f,Tufanoğlu F,KADIÇEŞME Ö Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. Türk Osteoporoz Dergisi. 2019; 25(2): 49 - 52. 10.4274/tod.galenos.2019.16023
Vancouver bağcıer f,Tufanoğlu F,KADIÇEŞME Ö Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?. Türk Osteoporoz Dergisi. 2019; 25(2): 49 - 52. 10.4274/tod.galenos.2019.16023
IEEE bağcıer f,Tufanoğlu F,KADIÇEŞME Ö "Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?." Türk Osteoporoz Dergisi, 25, ss.49 - 52, 2019. 10.4274/tod.galenos.2019.16023
ISNAD bağcıer, fatih vd. "Is There Any Relationship Between Serum Endocan Levels and Carotid Intima-media Thickness in Patients with Fibromyalgia?". Türk Osteoporoz Dergisi 25/2 (2019), 49-52. https://doi.org/10.4274/tod.galenos.2019.16023