Yıl: 2019 Cilt: 25 Sayı: 3 Sayfa Aralığı: 105 - 110 Metin Dili: İngilizce DOI: 10.4274/tod. galenos.2019.35119 İndeks Tarihi: 06-05-2020

Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study

Öz:
Objective: The aim of our study was to compare plasma vitamin D levels between patients with breast cancer-related lymphedema (BCRL)and healthy population, and also to investigate the effects of socio-demographic and clinical factors and lymphedema severity on vitamin Dlevels.Materials and Methods: Eighty patients with BCRL [mean age 55.5±8.9 (36-81)] and age- and sex-matched 80 healthy controls [meanage 53.7±7.4 (32-70)] who were not on calcium or vitamin D supplementation were included in the study. Socio-demographic and clinicalcharacteristics of the subjects were questioned. Plasma 25-Hydroxyvitamin D3, calcium, phosphorus, alkaline phosphatase (ALP), andparathormone (PTH) levels were evaluated. Lymphedema was classified as stage 0, I, II, or III.Results: The mean duration of lymphedema was 23.5±13.8 months. Comparisons revealed lower vitamin D levels and higher PTH andALP levels in patients with BCRL than healthy controls. As a result of multivariate regression analysis, a significant relationship was revealedbetween vitamin D levels and age, breast cancer stage, and disease duration in patients with BCRL. Vitamin D levels were significantly lowerand PTH levels were significantly higher in stage 3 lymphedema patients compared to stage 1.Conclusion: Vitamin D levels were detected lower in patients with lymphedema than healthy controls. Although vitamin D levels were foundto be lower in patients with severe lymphedema, the multivariate regression analysis revealed that the severity of lymphedema does not havea significant effect on vitamin D levels.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Romatoloji

Meme Kanseri İlişkili Lenfödem Hastalarında Vitamin D Düzeylerinin Değerlendirilmesi: Kesitsel Gözlemsel Araştırma

Öz:
Amaç: Çalışmamızın amacı meme kanseri ile ilişkili lenfödem (MKİL) ve sağlıklı popülasyondaki hastalarda plazma D vitamini düzeylerini karşılaştırmak ayrıca sosyo-demografik ve klinik faktörlerin ve lenfödem şiddetinin D vitamini düzeylerine etkilerini tespit etmekti. Gereç ve Yöntem: MKİL’li 80 hasta [yaş ortalaması 55,5±8,9 (36-81)] ve kalsiyum ya da Vitamin D tedavisi altında olmayan 80 yaş ve cinsiyet uyumlu sağlıklı kontrol [yaş ortalaması 53,7±7,4 (32-70)] çalışmaya alındı. Olguların sosyo-demografik ve klinik özellikleri sorgulandı. Plazma 25-Hydroxyvitamin D3, kalsiyum, fosfor, alkalen fosfataz (ALP), parathormon (PTH) düzeyleri değerlendirildi. Lenfödem evre 0, I, II veya III olarak sınıflandırıldı. Bulgular: Ortalama lenfödem süresi 23,5±13,8 aydı. MKİL’li hastalarda sağlıklı kontrollere oranla daha düşük D vitamini düzeyleri ve daha yüksek PTH ve ALP düzeyleri saptandı. Çok değişkenli regresyon analizi sonucunda, MKİL hastalarında D vitamini düzeyleri ile yaş, meme kanseri evresi ve hastalık süresi arasında anlamlı bir ilişki olduğu ortaya çıkarıldı. Evre 3 lenfödem hastalarında, evre 1’e kıyasla D vitamini düzeyi daha düşük ve PTH düzeyi anlamlı olarak daha yüksekti. Sonuç: D vitamini düzeyleri lenfödemli hastalarda sağlıklı kontrollere oranla daha düşük saptanmıştır. Şiddetli lenfödemi olan hastalarda D vitamini düzeylerinin daha düşük saptanmasına rağmen, çok değişkenli regresyon analizi lenfödem şiddetinin D vitamini düzeyleri üzerinde anlamlı bir etkisi olmadığını ortaya koymuştur.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Romatoloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA SEZGİN ÖZCAN D, dalyan m, ERGÜL S, ÜNSAL-DELİALİOĞLU S, Köseoğlu B (2019). Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. , 105 - 110. 10.4274/tod. galenos.2019.35119
Chicago SEZGİN ÖZCAN Didem,dalyan meltem,ERGÜL Serhat,ÜNSAL-DELİALİOĞLU Sibel,Köseoğlu Belma Füsun Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. (2019): 105 - 110. 10.4274/tod. galenos.2019.35119
MLA SEZGİN ÖZCAN Didem,dalyan meltem,ERGÜL Serhat,ÜNSAL-DELİALİOĞLU Sibel,Köseoğlu Belma Füsun Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. , 2019, ss.105 - 110. 10.4274/tod. galenos.2019.35119
AMA SEZGİN ÖZCAN D,dalyan m,ERGÜL S,ÜNSAL-DELİALİOĞLU S,Köseoğlu B Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. . 2019; 105 - 110. 10.4274/tod. galenos.2019.35119
Vancouver SEZGİN ÖZCAN D,dalyan m,ERGÜL S,ÜNSAL-DELİALİOĞLU S,Köseoğlu B Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. . 2019; 105 - 110. 10.4274/tod. galenos.2019.35119
IEEE SEZGİN ÖZCAN D,dalyan m,ERGÜL S,ÜNSAL-DELİALİOĞLU S,Köseoğlu B "Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study." , ss.105 - 110, 2019. 10.4274/tod. galenos.2019.35119
ISNAD SEZGİN ÖZCAN, Didem vd. "Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study". (2019), 105-110. https://doi.org/10.4274/tod. galenos.2019.35119
APA SEZGİN ÖZCAN D, dalyan m, ERGÜL S, ÜNSAL-DELİALİOĞLU S, Köseoğlu B (2019). Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. Türk Osteoporoz Dergisi, 25(3), 105 - 110. 10.4274/tod. galenos.2019.35119
Chicago SEZGİN ÖZCAN Didem,dalyan meltem,ERGÜL Serhat,ÜNSAL-DELİALİOĞLU Sibel,Köseoğlu Belma Füsun Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. Türk Osteoporoz Dergisi 25, no.3 (2019): 105 - 110. 10.4274/tod. galenos.2019.35119
MLA SEZGİN ÖZCAN Didem,dalyan meltem,ERGÜL Serhat,ÜNSAL-DELİALİOĞLU Sibel,Köseoğlu Belma Füsun Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. Türk Osteoporoz Dergisi, vol.25, no.3, 2019, ss.105 - 110. 10.4274/tod. galenos.2019.35119
AMA SEZGİN ÖZCAN D,dalyan m,ERGÜL S,ÜNSAL-DELİALİOĞLU S,Köseoğlu B Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. Türk Osteoporoz Dergisi. 2019; 25(3): 105 - 110. 10.4274/tod. galenos.2019.35119
Vancouver SEZGİN ÖZCAN D,dalyan m,ERGÜL S,ÜNSAL-DELİALİOĞLU S,Köseoğlu B Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study. Türk Osteoporoz Dergisi. 2019; 25(3): 105 - 110. 10.4274/tod. galenos.2019.35119
IEEE SEZGİN ÖZCAN D,dalyan m,ERGÜL S,ÜNSAL-DELİALİOĞLU S,Köseoğlu B "Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study." Türk Osteoporoz Dergisi, 25, ss.105 - 110, 2019. 10.4274/tod. galenos.2019.35119
ISNAD SEZGİN ÖZCAN, Didem vd. "Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study". Türk Osteoporoz Dergisi 25/3 (2019), 105-110. https://doi.org/10.4274/tod. galenos.2019.35119