TY  - JOUR
TI  - Evaluation of Vitamin D Levels in Patients with Breast Cancerrelated Lymphedema: An Observational Cross-sectional Study
AB  - Objective: The aim of our study was to compare plasma vitamin D levels between patients with breast cancer-related lymphedema (BCRL)and healthy population, and also to investigate the effects of socio-demographic and clinical factors and lymphedema severity on vitamin Dlevels.Materials and Methods: Eighty patients with BCRL [mean age 55.5±8.9 (36-81)] and age- and sex-matched 80 healthy controls [meanage 53.7±7.4 (32-70)] who were not on calcium or vitamin D supplementation were included in the study. Socio-demographic and clinicalcharacteristics of the subjects were questioned. Plasma 25-Hydroxyvitamin D3, calcium, phosphorus, alkaline phosphatase (ALP), andparathormone (PTH) levels were evaluated. Lymphedema was classified as stage 0, I, II, or III.Results: The mean duration of lymphedema was 23.5±13.8 months. Comparisons revealed lower vitamin D levels and higher PTH andALP levels in patients with BCRL than healthy controls. As a result of multivariate regression analysis, a significant relationship was revealedbetween vitamin D levels and age, breast cancer stage, and disease duration in patients with BCRL. Vitamin D levels were significantly lowerand PTH levels were significantly higher in stage 3 lymphedema patients compared to stage 1.Conclusion: Vitamin D levels were detected lower in patients with lymphedema than healthy controls. Although vitamin D levels were foundto be lower in patients with severe lymphedema, the multivariate regression analysis revealed that the severity of lymphedema does not havea significant effect on vitamin D levels.
AU  - ERGÜL, Serhat
AU  - SEZGİN ÖZCAN, Didem
AU  - ÜNSAL-DELİALİOĞLU, Sibel
AU  - Köseoğlu, Belma Füsun
AU  - dalyan, meltem
DO  - 10.4274/tod. galenos.2019.35119
PY  - 2019
JO  - Türk Osteoporoz Dergisi
VL  - 25
IS  - 3
SN  - 2147-2653
SP  - 105
EP  - 110
DB  - TRDizin
UR  - http://search/yayin/detay/335505
ER  -