The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever
Yıl: 2019 Cilt: 49 Sayı: 4 Sayfa Aralığı: 1192 - 1197 Metin Dili: İngilizce DOI: 10.3906/sag-1812-10 İndeks Tarihi: 13-05-2020
The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever
Öz: Background/aim: Crimean-Congo hemorrhagic fever (CCHF) is a serious illness characterized by fever and hemorrhage. Endothelin-1(ET-1), angiopoietin-2 (Ang-2), and endothelial cell-specific receptor tyrosine kinase (Tie-2) are believed to be important markers ofthe pathogenesis, clinical course, and prognosis of the disease. The aim of this study was to determine ET-1, Ang-2, and Tie-2 levels inadults with CCHF and investigate the associations between these markers and pathogenesis and disease course.Materials and methods: Sixty CCHF patients were included in the study. The patients were classified according to disease severitycriteria and Ang-2, Tie-2, and ET-1 levels were compared.Results: Mean serum ET-1 level was 36.62 ± 27.99 pg/mL in the patient group and 3.70 ± 4.71 pg/mL in the control group (P = 0.001).Mean serum Ang-2 levels were 2511.18 ± 1018.64 pg/mL in the patient group and 3570.76 ± 209.52 pg/mL in the control group (P =0.001). Mean serum Tie-2 levels were 7.35 ± 7.75 ng/mL in the patient group and 0.67 ± 1.26 ng/mL in the control group (P = 0.001).Conclusion: Elevated ET-1 and Tie-2 levels were associated with more severe disease course, while Ang-2 level was negatively correlatedwith severity in adult CCHF patients. ET-1, Tie-2, and Ang-2 levels are important prognostic parameters in CCHF and may contributesignificantly to treatment and follow-up.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Nadar SK, Karalis I, Al Yemeni E, Blann AD, Lip GY. Plasma markers of angiogenesis in pregnancy induced hypertension. Thrombosis and Haemostasis 2005; 94 (5): 1071-1076. doi: 10.1160/TH05-03-0167
- 2. Zwingenberger K, Harms G, Feldmeier H, Müller O, Steiner A et al. Liver involvement in human Schistosomiasis mansoni. Regression of immunological and biochemical disease markers after specific treatment. Acta Tropica 1988; 45 (3): 263-275.
- 3. Beghetti M, Black SM, Fineman JR. Endothelin-1 in congenital heart disease. Pediatric Research 2005; 57: 16R-20R. doi: 10.1203/01.PDR.0000160447.83332.13
- 4. Arslan M, Yilmaz G, Mentese A, Yilmaz H, Karahan SC et al. Importance of endothelial dysfunction biomarkers in patients with Crimean‐Congo hemorrhagic fever. Journal of Medical Virology 2017; 89 (12): 2084-2091. doi: 10.1002/jmv.24881
- 5. Gomes LT, Alves-Junior ER, Rodrigues-Jesus C, Nery AF, Gasquez-Martin TO et al. Angiopoietin-2 and angiopoietin-2/ angiopoietin-1 ratio as indicators of potential severity of Plasmodium vivax malaria in patients with thrombocytopenia. PLoS One 2014; 9 (10): e109246. doi: 10.1371/journal. pone.0109246
- 6. Sancakdar E, Guven AS, Uysal EB, Deveci K, Gültürk E. Important of angiopoietic system in evaluation of endothelial damage in children with Crimean–Congo hemorrhagic fever. Pediatric Infectious Disease Journal 2015; 34 (8): e200-e205. doi: 10.1097/INF.0000000000000706
- 7. Ergonul O, Seref C, Eren S, Celikbas A, Baykam N et al. Cytokine response in Crimean‐Congo hemorrhagic fever virus infection. Journal of Medical Virology 2017; 89 (10): 1707- 1713. doi: 10.1002/jmv.24864
- 8. Swanepoel R, Gill D, Shepherd A, Leman P, Mynhardt J et al. The clinical pathology of Crimean-Congo hemorrhagic fever. Reviews of Infectious Diseases 1989; 11 (Suppl. 4): 794-800.
- 9. Whitehouse CA. Crimean–Congo hemorrhagic fever. Antiviral Research 2004; 64 (3): 145-160. doi: 10.1016/j. antiviral.2004.08.001
- 10. Burt FJ, Swanepoel R, Shieh WJ, Smith JF. Immunohistochemical and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis. Archives of Pathology & Laboratory Medicine 1997; 121 (8): 839.
- 11. Fisman DN. Hemophagocytic syndromes and infection. Emerging Infectious Diseases 2000; 6 (6): 601. doi: 10.3201/ eid0606.000608
- 12. Mammen EF. Disseminated intravascular coagulation (DIC). Clinical Laboratory Science 2000; 13 (4): 239.
- 13. Bakir M, Ugurlu M, Dokuzoguz B, Bodur H, Tasyaran MA et al. Crimean-Congo haemorrhagic fever outbreak in Middle Anatolia: a multicentre study of clinical features and outcome measures. Journal of Medical Microbiology 2005; 54 (4): 385- 389. doi: 10.1099/jmm.0.45865-0
- 14. Güler AK. Relationship between serum TNF-alpha and IL-6 levels in clinical course and role in prognosis in patients with Crimean-Congo hemorrhagic fever. PhD, Atatürk University, Erzurum, Turkey, 2012.
- 15. Ozturk B, Kuscu F, Tutuncu E, Sencan I, Gurbuz Y et al. Evaluation of the association of serum levels of hyaluronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patients with Crimean-Congo hemorrhagic fever. Journal of Clinical Virology 2010; 47 (2): 115-119. doi: 10.1016/j.jcv.2009.10.015
- 16. Ozkurt Z. Vascular endothelial growth factor levels in patients with Crimean Congo hemorrhagic fever. In: Proceedings of the 21st ESCMID, Milan, Italy, p. 2555.
- 17. Phanthanawiboon S, Limkittikul K, Sakai Y, Takakura N, Saijo M et al. Acute systemic infection with dengue virus leads to vascular leakage and death through tumor necrosis factor-α and Tie2/angiopoietin signaling in mice lacking type I and II interferon receptors. PLoS One 2016; 11 (2): e0148564. doi: 10.1371/journal.pone.0148564
- 18. Parikh SM. Angiopoietins and Tie2 in vascular inflammation. Current Opinion in Hematology 2017; 24 (5): 432-438. doi: 10.1097/MOH.0000000000000361
- 19. Premaratne M, Perera S, Malavige G, Jayasinghe S. Mathematical modelling of immune parameters in the evolution of severe dengue. Computational and Mathematical Methods in Medicine 2017; 2017: 2187390. doi: 10.1155/2017/2187390
| APA | Kerget F, ÖZKURT Z, Ozturk N, YILMAZ S (2019). The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. , 1192 - 1197. 10.3906/sag-1812-10 |
| Chicago | Kerget Ferhan,ÖZKURT Zülal,Ozturk Nurinnisa,YILMAZ Sinan The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. (2019): 1192 - 1197. 10.3906/sag-1812-10 |
| MLA | Kerget Ferhan,ÖZKURT Zülal,Ozturk Nurinnisa,YILMAZ Sinan The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. , 2019, ss.1192 - 1197. 10.3906/sag-1812-10 |
| AMA | Kerget F,ÖZKURT Z,Ozturk N,YILMAZ S The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. . 2019; 1192 - 1197. 10.3906/sag-1812-10 |
| Vancouver | Kerget F,ÖZKURT Z,Ozturk N,YILMAZ S The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. . 2019; 1192 - 1197. 10.3906/sag-1812-10 |
| IEEE | Kerget F,ÖZKURT Z,Ozturk N,YILMAZ S "The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever." , ss.1192 - 1197, 2019. 10.3906/sag-1812-10 |
| ISNAD | Kerget, Ferhan vd. "The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever". (2019), 1192-1197. https://doi.org/10.3906/sag-1812-10 |
| APA | Kerget F, ÖZKURT Z, Ozturk N, YILMAZ S (2019). The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. Turkish Journal of Medical Sciences, 49(4), 1192 - 1197. 10.3906/sag-1812-10 |
| Chicago | Kerget Ferhan,ÖZKURT Zülal,Ozturk Nurinnisa,YILMAZ Sinan The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. Turkish Journal of Medical Sciences 49, no.4 (2019): 1192 - 1197. 10.3906/sag-1812-10 |
| MLA | Kerget Ferhan,ÖZKURT Zülal,Ozturk Nurinnisa,YILMAZ Sinan The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. Turkish Journal of Medical Sciences, vol.49, no.4, 2019, ss.1192 - 1197. 10.3906/sag-1812-10 |
| AMA | Kerget F,ÖZKURT Z,Ozturk N,YILMAZ S The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. Turkish Journal of Medical Sciences. 2019; 49(4): 1192 - 1197. 10.3906/sag-1812-10 |
| Vancouver | Kerget F,ÖZKURT Z,Ozturk N,YILMAZ S The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever. Turkish Journal of Medical Sciences. 2019; 49(4): 1192 - 1197. 10.3906/sag-1812-10 |
| IEEE | Kerget F,ÖZKURT Z,Ozturk N,YILMAZ S "The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever." Turkish Journal of Medical Sciences, 49, ss.1192 - 1197, 2019. 10.3906/sag-1812-10 |
| ISNAD | Kerget, Ferhan vd. "The relationship with clinical course and prognosis of serum endothelin-1, angiopoietin-2, and tie-2 levels in Crimean-Congo hemorrhagic fever". Turkish Journal of Medical Sciences 49/4 (2019), 1192-1197. https://doi.org/10.3906/sag-1812-10 |
