TY  - JOUR
TI  - Neutrophil to lymphocyte ratio as a predictor of treatment response and mortality in septic shock patients in the intensive care unit
AB  - Background/aim: While C-reactive protein (CRP) is a well-studied marker for predicting treatment response and mortality in sepsis,it was aimed to assess the efficacy of the neutrophil lymphocyte ratio (NLR) as a predictor of mortality and treatment response in sepsispatients in the intensive care unit (ICU). Materials and methods: In this retrospective cross-sectional study, sepsis patients were divided according to the presence of septic shockon the 1st day of ICU stay, and then subgrouped according to mortality. Patient demographics, acute physiologic and chronic healthevaluation II and sequential organ failure assessment scores, NLR and CRP (on the 1st, 3rd, and last day in the ICU), microbiology data,antibiotic responses, ICU data, and mortality were recorded. Receiver operating characteristic (ROC) curves for the area under curve(AUC) were calculated for the inflammatory markers and ICU severity scores for mortality.Results: Of the 591 (65% male) enrolled patients, 111 (18.8%) were nonsurvivors with shock, 117 (19.8%) were survivors with shock,330 (55.8%) were survivors without shock, and 33 (5.6%) were nonsurvivors without shock. On the 1st day of ICU stay, the NLR andCRP were similar in all of the groups. On the 3rd day of antibiotic response, the NLR was increased (11.8) in the nonresponsive patientswhen compared with the partially responsive (11.0) and responsive (8.5) patients. If the NLR was ≥15 on the 3rd day, the mortality oddsratio was 6.96 (CI: 1.4–34.1, P < 0.017). The NLR and CRP on the 1st, 3rd, and last day of ICU stay (0.52, 0.58, 0.78 and 0.56, 0.70, 0.78,respectively) showed a similar increasing trend for mortality.Conclusion: The NLR can predict mortality and antibiotic responsiveness in ICU patients with sepsis and septic shock. If the NLRis >15 on the 3rd day of postantibiotic initiation, the risk of mortality is high and treatment should be reviewed carefully.
AU  - ADIGÜZEL, NALAN
AU  - YAZICIOĞLU MOÇİN, Özlem
AU  - Ciyiltepe, Fulya
AU  - kargın, Feyza
AU  - Salturk, Cuneyt
AU  - ÇELİK, Muhammed Emin
AU  - YALAZ TEKAN, Ülgen
AU  - GÜNGÖR, Gökay
AU  - SARI, Rabia
AU  - Ay, Mustafa
AU  - KARAKURT, ZÜHAL
DO  - 10.3906/sag-1901-105
PY  - 2019
JO  - Turkish Journal of Medical Sciences
VL  - 49
IS  - 5
SN  - 1300-0144
SP  - 1336
EP  - 1349
DB  - TRDizin
UR  - http://search/yayin/detay/336686
ER  -