The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels

TURAN, Elif; OZAN, Zeynep Tuğba; BÖREKCİ, ELİF; göçmen, ayşe yeşim; ARAL, Yalçın; YILDIRIM, Tekin

doi:10.3906/sag-1905-106

The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels

Tekin YILDIRIM, (Yozgat Bozok Üniversitesi)

Ayşe Yeşim GÖÇMEN, (Yozgat Bozok Üniversitesi)

Zeynep Tuğba OZAN, (Yozgat Bozok Üniversitesi)

ELİF BÖREKCİ, (Manisa Celal Bayar Üniversitesi)

Elif TURAN, (Yozgat Bozok Üniversitesi)

Yalçın ARAL (Yozgat Bozok Üniversitesi)

Turkish Journal of Medical Sciences

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Yıl: 2019 Cilt: 49 Sayı: 6 Sayfa Aralığı: 1742 - 1747 Metin Dili: İngilizce DOI: 10.3906/sag-1905-106 İndeks Tarihi: 16-05-2020

The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels

Öz:

Background/aim: The possibility of adverse effects of the oral glucose tolerance test (OGTT) carried out for the screening of gestationaldiabetes among pregnant women and fetuses is a frequently discussed topic. The purpose of this study was to investigate the effects ofthe hyperglycemia peak during OGTT on the levels of oxidants and antioxidants in the body.Materials and methods: Eighty individuals who applied to the Outpatient Clinic with suspected diabetes and OGTT indication wereincluded in the study. Glucose, total oxidant capacity status (TOS), total antioxidant capacity (TAS), superoxide dismutase (SOD), andlipid hydroperoxide (LOOH) levels were tested on blood samples collected from these individuals at 0, 60, and 120 min during theOGTT carried out with 75 g of glucose. Oxidative stress index (OSI) was calculated as the ratio of TOS to TAS.Results: While the oxidative parameters TOS and LOOH were significantly increased at 60. min of OGTT, only LOOH was significantlyincreased at 120. min of OGTT. Significant decreases in antioxidative parameters (TAS, SOD) were observed at 60. and 120. min of theOGTT and OSI was significantly increased at 60. and 120. min of the OGTT.Conclusion: Oxidative stress parameters were increased and antioxidative parameters were decreased during the OGTT. However,more extended studies are required to determine the effects of the increased oxidative stress on pregnant women and fetuses.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILDIRIM T, göçmen a, OZAN Z, BÖREKCİ E, TURAN E, ARAL Y (2019). The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. , 1742 - 1747. 10.3906/sag-1905-106
Chicago	YILDIRIM Tekin,göçmen ayşe yeşim,OZAN Zeynep Tuğba,BÖREKCİ ELİF,TURAN Elif,ARAL Yalçın The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. (2019): 1742 - 1747. 10.3906/sag-1905-106
MLA	YILDIRIM Tekin,göçmen ayşe yeşim,OZAN Zeynep Tuğba,BÖREKCİ ELİF,TURAN Elif,ARAL Yalçın The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. , 2019, ss.1742 - 1747. 10.3906/sag-1905-106
AMA	YILDIRIM T,göçmen a,OZAN Z,BÖREKCİ E,TURAN E,ARAL Y The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. . 2019; 1742 - 1747. 10.3906/sag-1905-106
Vancouver	YILDIRIM T,göçmen a,OZAN Z,BÖREKCİ E,TURAN E,ARAL Y The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. . 2019; 1742 - 1747. 10.3906/sag-1905-106
IEEE	YILDIRIM T,göçmen a,OZAN Z,BÖREKCİ E,TURAN E,ARAL Y "The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels." , ss.1742 - 1747, 2019. 10.3906/sag-1905-106
ISNAD	YILDIRIM, Tekin vd. "The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels". (2019), 1742-1747. https://doi.org/10.3906/sag-1905-106

APA	YILDIRIM T, göçmen a, OZAN Z, BÖREKCİ E, TURAN E, ARAL Y (2019). The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. Turkish Journal of Medical Sciences, 49(6), 1742 - 1747. 10.3906/sag-1905-106
Chicago	YILDIRIM Tekin,göçmen ayşe yeşim,OZAN Zeynep Tuğba,BÖREKCİ ELİF,TURAN Elif,ARAL Yalçın The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. Turkish Journal of Medical Sciences 49, no.6 (2019): 1742 - 1747. 10.3906/sag-1905-106
MLA	YILDIRIM Tekin,göçmen ayşe yeşim,OZAN Zeynep Tuğba,BÖREKCİ ELİF,TURAN Elif,ARAL Yalçın The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. Turkish Journal of Medical Sciences, vol.49, no.6, 2019, ss.1742 - 1747. 10.3906/sag-1905-106
AMA	YILDIRIM T,göçmen a,OZAN Z,BÖREKCİ E,TURAN E,ARAL Y The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. Turkish Journal of Medical Sciences. 2019; 49(6): 1742 - 1747. 10.3906/sag-1905-106
Vancouver	YILDIRIM T,göçmen a,OZAN Z,BÖREKCİ E,TURAN E,ARAL Y The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels. Turkish Journal of Medical Sciences. 2019; 49(6): 1742 - 1747. 10.3906/sag-1905-106
IEEE	YILDIRIM T,göçmen a,OZAN Z,BÖREKCİ E,TURAN E,ARAL Y "The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels." Turkish Journal of Medical Sciences, 49, ss.1742 - 1747, 2019. 10.3906/sag-1905-106
ISNAD	YILDIRIM, Tekin vd. "The effect of hyperglycemic peak induced by oral glucose tolerance test on the oxidant and antioxidant levels". Turkish Journal of Medical Sciences 49/6 (2019), 1742-1747. https://doi.org/10.3906/sag-1905-106