TY  - JOUR
TI  - Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication
AB  - Objective: The studies about use of pregabalin for premedication have been recently carried out dueto pregabalin has analgesic and anxiolytic effects together. We aimed to evaluate the effects of preoperative pregabalin on anxiety score, hemodynamic parameters, postoperative pain and analgesic consumption in patientsundergoing elective abdominal hysterectomy. Material and Methods: The patients were randomly separatedinto 34 patients of two groups. This prospective randomized, double-blind and placebo-controlled study was performed in patients undergoing elective abdominal hysterectomy. Pregabalin 150 mg (Pregabalin Group) orplacebo 150 mg empty capsule (Control Group) was given to the patients 12 hours and 1 hour before operation.STAI-I (State-Trait Anxiety Inventory-I) anxiety scale were performed to the patients during preoperative examination and 1 hour before operation. In both groups, intraoperative hemodynamic parameters, postoperativepain levels with VAS (Visual Analogue Scale), morphine consumption and developing side effects were recordedand analyzed. Results: When all patients were compared from the point of demographic data, no difference wasfound between groups. STAI-I points were found significantly different between Pregabalin and Control groupsboth premedication and postmedication phases. MAP (Mean Arterial Pressure) data were found lower in pregabalin group at intraoperative 30th, 40th and 75th minutes and postoperative 1st minute (p<0.05). PostoperativeVAS values were found lower in Pregabalin Group. Additional analgesic use and morphine consumption, werelower in Pregabalin group except 1st and 30th minutes. When both groups, examined with regard to side effects,side effect rates of Control Group were 29% and rates of Pregabalin Group were 10%. Conclusion: In this study,it was concluded that pregabalin use at 12 and 1 hour before operation decreased preoperative anxiety score, provided postoperative analgesia and found superior to placebo due to decreasing side effects via decreasing the consumption of analgesics, however for the routine use of pregabalin in premedication it was needed further studieswith different doses and large sample sizes.
AU  - Avcı, Onur
AU  - KAYGUSUZ, KENAN
AU  - ÖZDEMİR KOL, İclal
AU  - GÜRSOY, Sinan
AU  - İSBİR, Ahmet Cemil
AU  - BORA POLAT, Selma
DO  - 10.5336/medsci.2018-62181
PY  - 2019
JO  - Türkiye Klinikleri Tıp Bilimleri Dergisi
VL  - 39
IS  - 1
SN  - 1300-0292
SP  - 9
EP  - 18
DB  - TRDizin
UR  - http://search/yayin/detay/337934
ER  -