Objective: The aim of the present study was to evaluate the analgesic efficacy of pre-emptive intravenous (iv) ibuprofen on pain during and afterthe mandibular third molar surgery.Methods: A total of 60 patients were included in the study. They were allocated as ibuprofen 800 mg iv+dexketoprofen 50 mg (group 1), ibuprofen800 mg iv alone (group 2) or placebo (group 3). A local anaesthetic infiltration was administered to all patients. In all patients, haemodynamic values(mean arterial pressure (MAP) and heart rate (HR)) were recorded preoperatively, and infusions were started. State-Trait Anxiety Inventory (STAI)scale was used to assess anxiety states. Surgery started 15 min after the infusion. Haemodynamic values and pain scores with visual analogue scale(VAS) were recorded. Pain scores were recorded postoperatively at rest (VASR) and swallowing (VASS).Results: There was no significant difference in the preoperative STAI values between the groups (p>0.05). HR, MAP and VAS pain scores weresignificantly higher in group 3 than in groups 1 and 2 (p<0.05). VASR and VASS scores were significantly higher in group 3 than in group 1 in thefirst 4 h postoperatively (p<0.05). VASS scores were significantly higher in group 3 than in group 2 at 1-4 h postoperatively (p<0.05), but there wasno difference in VASR and VASS scores at 48 h after surgery.Conclusion: Ibuprofen alone or in combination with dexketoprofen provided similar analgesia in the perioperative period when administeredpre-emptively