Yıl: 2019 Cilt: 43 Sayı: 4 Sayfa Aralığı: 210 - 212 Metin Dili: İngilizce DOI: 10.4274/tpd.galenos.2019.6362 İndeks Tarihi: 04-06-2020

Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey

Öz:
Leishmaniasis is a neglected disease that is prevalent in tropical and subtropical regions of the world. Even though cutaneousleishmaniasis is the most common form, visceral leishmaniasis is associated with high mortality. The case presented herein isa 39 year-old bed-ridden female who presented with fever of unknown origin, tachypnea and pancytopenia. She was initiallymisdiagnosed as having autoimmune pancytopenia elsewhere and treated with corticosteroids and intravenous immunoglobulin.She had also received wide-spectrum antibiotics for febrile neutropenia. We performed a leishmania rK39 dipstick test whichturned out to be positive along with visualisation of amastigote forms of leishmania on bone marrow biopsy. Thus, we madea diagnosis of visceral leishmaniasis and treated her with liposomal amphotericin B. Her clinical course was complicated byrespiratory failure necessitating invasive mechanical ventilation. She responded well to treatment and was later extubated, shortly before being discharged. At 6 months of follow-up, no sign of recurrence was observed.
Anahtar Kelime:

Türkiye’nin Düşük Endemik Bölgesinden Nedeni Bilinmeyen Ateşle Başvuran Bir Visseral Leyişmaniyaz Olgusu

Öz:
Leyişmaniyaz, tropik ve subtropik bölgelerde sık görülen ihmal edilmiş bir hastalıktır. Kutanöz leyişmaniyaz en sık görülen formu olsa da visseral leyişmaniyaz yüksek mortalite ile ilişkili olanıdır. Bu olgu sunumunda nedeni bilinmeyen ateş, takipne ve pansitopeni ile prezente olan 39 yaşında yatağa bağımlı bir kadın hasta rapor edilmektedir. Başka bir merkezde otoimmün pansitopeni tanısı ile kortikosteroid ve intravenöz immünoglobulin tedavileri, febril nötropeni için geniş spektrumlu antibiyotik tedavisi almıştır. Hastanın merkezimizde yapılan leyişmaniyaz rK39 dipstik testi pozitif sonuçlandı ve kemik iliği biyopsisinde amastigot formları görüldü. Hastaya visseral leyişmaniyaz tanısı konularak lipozomal amfoterisin B tedavisi başlandı. Klinik seyri invaziv mekanik ventilasyonu gerektirecek solunum yetmezliği ile komplike oldu. Tedaviye iyi yanıt veren hasta ekstübe edildi ve daha sonra taburcu edildi. Taburculuktan 6 ay sonraki kontrolünde relaps bulgusu saptanmadı.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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  • 1. World Health Organization. Leishmaniasis. Available from: http:// www.who.int/leishmaniasis/disease/clinical_forms_leishmaniases/en/ index2.html
  • 2. Centers for Disease Control and Prevention (CDC). Epidemiology and Risk factors of Leishmaniasis. Available from: https://www.cdc.gov/ parasites/leishmaniasis/epi.html
  • 3. World Health Organization. Report of a meeting of the WHO Expert Committee on the control of leishmaniases. WHO Technical Report Series: 2010 Mar. Report no.: 949.
  • 4. World Health Organization. Leishmaniasis in high-burden countries: an epidemiological update based on data reported in 2014. Weekly Epidemiological Record 2016;91:285-96.
  • 5. Gürel MS, Yeşilova Y, Ölgen MK, Özbel Y. Cutaneous leishmaniasis in Turkey. Turkiye Parazitol Derg 2012;36:121-9.
  • 6. Koltas IS, Eroglu F, Alabaz D, Uzun D. The emergence of Leishmania major and Leishmania donovani in southern Turkey. Trans R Soc Trop Med Hyg 2014;108:154-8.
  • 7. Pullukçu H, Turgay N, Işıkgöz Taşbakan M, Akyol D, Sipahi OR, Yamazhan T, et al. Fever of Unknown Origin and Visceral Leishmaniasis: a series of 20 Adult Patients. FLORA 2018;23:92-4.
  • 8. Kawakami A, Fukunaga T, Usui M, Asaoka H, Noda M, Nakajima T ,et al. Visceral Leishmaniasis misdiagnosed as malignant lymphoma. Intern Med 1996;35:502-6.
  • 9. Ozensoy Toz S, Sakru N, Ertabaklar H, Demir S, Sensgul M, Ozbel Y. Serological and Entomological Survey of Zoonotic Visceral Leishmaniasis in Denizli Province, Aegean Region, Turkey. New Microbiologica, 2009;32:93-100.
  • 10. Bosilkovski M, Dimozva M, Stevanovic M, Cvetkovska VS, Duganovska M. Fever of unknown origin--diagnostic methods in a European developing country. Voinosanit Pregl 2016;73:553-8.
  • 11. WOrld Health Organization. Available from: https://www.who.int/ leishmaniasis/resources/Turkey_CP_2014.pdf
  • 12. Bekele T. Guideline for diagnosis, treatment and prevention of visceral leishmaniasis in Ethiopia. 2nd ed. 2013
  • 13. Srivastava P, Dayama A, Mehrotra S, & Sundar S.. Diagnosis of visceral leishmaniasis. Trans R Soc Trop Med Hyg 2011;105:1-6.
  • 14. Moore EM, Lockwood DN. Treatment of Visceral Leishmaniasis. J Glob Infect Dis 2010;2:151-8.
APA Jaiteh M, ÇALIK BAŞARAN N, ÖZIŞIK L, AKMAN O, HASANLI N, Tortop S, ÖZMEN ÇAPIN B, HÜSEYİNOVA S, Uner A, İNKAYA A (2019). Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. , 210 - 212. 10.4274/tpd.galenos.2019.6362
Chicago Jaiteh Muhammed B.,ÇALIK BAŞARAN Nursel,ÖZIŞIK Lale,AKMAN Orkun,HASANLI Nasib,Tortop Sema,ÖZMEN ÇAPIN Büşra betül,HÜSEYİNOVA Sabine,Uner Aysegul,İNKAYA Ahmet Çağkan Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. (2019): 210 - 212. 10.4274/tpd.galenos.2019.6362
MLA Jaiteh Muhammed B.,ÇALIK BAŞARAN Nursel,ÖZIŞIK Lale,AKMAN Orkun,HASANLI Nasib,Tortop Sema,ÖZMEN ÇAPIN Büşra betül,HÜSEYİNOVA Sabine,Uner Aysegul,İNKAYA Ahmet Çağkan Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. , 2019, ss.210 - 212. 10.4274/tpd.galenos.2019.6362
AMA Jaiteh M,ÇALIK BAŞARAN N,ÖZIŞIK L,AKMAN O,HASANLI N,Tortop S,ÖZMEN ÇAPIN B,HÜSEYİNOVA S,Uner A,İNKAYA A Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. . 2019; 210 - 212. 10.4274/tpd.galenos.2019.6362
Vancouver Jaiteh M,ÇALIK BAŞARAN N,ÖZIŞIK L,AKMAN O,HASANLI N,Tortop S,ÖZMEN ÇAPIN B,HÜSEYİNOVA S,Uner A,İNKAYA A Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. . 2019; 210 - 212. 10.4274/tpd.galenos.2019.6362
IEEE Jaiteh M,ÇALIK BAŞARAN N,ÖZIŞIK L,AKMAN O,HASANLI N,Tortop S,ÖZMEN ÇAPIN B,HÜSEYİNOVA S,Uner A,İNKAYA A "Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey." , ss.210 - 212, 2019. 10.4274/tpd.galenos.2019.6362
ISNAD Jaiteh, Muhammed B. vd. "Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey". (2019), 210-212. https://doi.org/10.4274/tpd.galenos.2019.6362
APA Jaiteh M, ÇALIK BAŞARAN N, ÖZIŞIK L, AKMAN O, HASANLI N, Tortop S, ÖZMEN ÇAPIN B, HÜSEYİNOVA S, Uner A, İNKAYA A (2019). Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. Türkiye Parazitoloji Dergisi, 43(4), 210 - 212. 10.4274/tpd.galenos.2019.6362
Chicago Jaiteh Muhammed B.,ÇALIK BAŞARAN Nursel,ÖZIŞIK Lale,AKMAN Orkun,HASANLI Nasib,Tortop Sema,ÖZMEN ÇAPIN Büşra betül,HÜSEYİNOVA Sabine,Uner Aysegul,İNKAYA Ahmet Çağkan Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. Türkiye Parazitoloji Dergisi 43, no.4 (2019): 210 - 212. 10.4274/tpd.galenos.2019.6362
MLA Jaiteh Muhammed B.,ÇALIK BAŞARAN Nursel,ÖZIŞIK Lale,AKMAN Orkun,HASANLI Nasib,Tortop Sema,ÖZMEN ÇAPIN Büşra betül,HÜSEYİNOVA Sabine,Uner Aysegul,İNKAYA Ahmet Çağkan Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. Türkiye Parazitoloji Dergisi, vol.43, no.4, 2019, ss.210 - 212. 10.4274/tpd.galenos.2019.6362
AMA Jaiteh M,ÇALIK BAŞARAN N,ÖZIŞIK L,AKMAN O,HASANLI N,Tortop S,ÖZMEN ÇAPIN B,HÜSEYİNOVA S,Uner A,İNKAYA A Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. Türkiye Parazitoloji Dergisi. 2019; 43(4): 210 - 212. 10.4274/tpd.galenos.2019.6362
Vancouver Jaiteh M,ÇALIK BAŞARAN N,ÖZIŞIK L,AKMAN O,HASANLI N,Tortop S,ÖZMEN ÇAPIN B,HÜSEYİNOVA S,Uner A,İNKAYA A Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey. Türkiye Parazitoloji Dergisi. 2019; 43(4): 210 - 212. 10.4274/tpd.galenos.2019.6362
IEEE Jaiteh M,ÇALIK BAŞARAN N,ÖZIŞIK L,AKMAN O,HASANLI N,Tortop S,ÖZMEN ÇAPIN B,HÜSEYİNOVA S,Uner A,İNKAYA A "Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey." Türkiye Parazitoloji Dergisi, 43, ss.210 - 212, 2019. 10.4274/tpd.galenos.2019.6362
ISNAD Jaiteh, Muhammed B. vd. "Visceral Leishmaniasis in A Patient Presenting with Fever of Unknown Origin: A Case Report From a Low-endemic Region of Turkey". Türkiye Parazitoloji Dergisi 43/4 (2019), 210-212. https://doi.org/10.4274/tpd.galenos.2019.6362