TY  - JOUR
TI  - Rationale, design, and methodology of the EPIC (Epidemiology of Polypharmacy and Potential Drug-Drug Interactions in Elderly Cardiac Outpatients) study
AB  - Objective: The aim of this study is to assess the prevalence ofpolypharmacy, inappropriate drug use, and drug-drug interactions(DDIs) in elderly patients presenting at outpatient cardiology clinicsin Turkey.Methods: The EPIC (Epidemiology of Polypharmacy and PotentialDrug-Drug Interactions in Elderly Cardiac Outpatients) study willbe an observational, real-world, multicenter study conducted toevaluate DDIs and polypharmacy in elderly cardiac outpatients. Allconsecutive patients (aged ≥65 years) admitted to outpatient cardiologyclinics between July 30, 2018 and July 30, 2019 who providewritten, informed consent will be enrolled. A total of approximately5000 patients are to be enrolled in this non-interventional study. Allof the data will be collected at one point in time and current clinicalpractice will be evaluated (ClinicalTrials.gov NCT03370523).Results: Patient demographics, comorbid disease characteristics,laboratory test results, and details of medication use will be collectedusing self-reports and medical records. The severity of comorbid diseasewill be recorded and scored according to Charlson ComorbidityIndex (CCI) and patients will be divided into 3 groups: mild, thosewith a CCI score of 1–2; moderate, those with a CCI score of 3–4;and severe, those with a CCI score of ≥5. Polypharmacy will be definedas the use of 5 or more medications at one time. DDIs will bedetermined using the Lexicomp Online drug interaction screeningtool and potentially inappropriate medications will be defined basedon the 2015 update of the Beers Criteria for Potentially InappropriateMedication Use in Older Adults. Severe drug interactions will be definedas those in category D or X.Conclusion: EPIC will be the first large-scale study in Turkey toevaluate polypharmacy, potentially inappropriate medications, andDDIs in elderly cardiac outpatients in a real-world clinical setting.
AU  - GÜNEŞ, Hacı Murat
AU  - Tasar, Onur
AU  - BİTEKER, MURAT
AU  - ÇELİK, Yunus
AU  - ÖZKAN, Buğra
AU  - ÖZLEK, BÜLENT
AU  - ÖZLEK, EDA
AU  - doğan, volkan
AU  - ÇELİK, OĞUZHAN
AU  - ÇİL, CEM
AU  - basaran, ozcan
AU  - BEKAR, Lütfü
AU  - ÖZDEMİR, Halil İbrahim
AU  - TANIK, VEYSEL OZAN
AU  - ÖNAL, ÇAĞATAY
AU  - Simsek, Zeki
AU  - ŞAFAK, Özgen
AU  - KAÇMAZ, Caner
AU  - ÇEKİÇ, EDİP GÜVENÇ
DO  - 10.5543/tkda.2019.27724
PY  - 2019
JO  - Türk Kardiyoloji Derneği Arşivi
VL  - 47
IS  - 5
SN  - 1016-5169
SP  - 391
EP  - 398
DB  - TRDizin
UR  - http://search/yayin/detay/339945
ER  -